Pregnancy-induced oxidative stress and inflammation are not associated with impaired maternal neuronal activity or memory function DOI
Jessica L. Bradshaw,

E. Nicole Wilson,

Jennifer J. Gardner

et al.

AJP Regulatory Integrative and Comparative Physiology, Journal Year: 2024, Volume and Issue: 327(1), P. R35 - R45

Published: May 6, 2024

Pregnancy is associated with neural and behavioral plasticity, systemic inflammation, oxidative stress, yet the impact of inflammation stress on maternal plasticity during pregnancy unclear. We hypothesized that healthy transiently reduces learning memory these deficits are pregnancy-induced elevations in stress. Cognitive performance was tested novel object recognition (recollective memory), Morris water maze (spatial open field (anxiety-like) behavior tasks female Sprague-Dawley rats varying reproductive states [nonpregnant (nulliparous), pregnant (near term), 1-2 mo after (primiparous);

Language: Английский

Neuroanatomical changes observed over the course of a human pregnancy DOI Creative Commons
Laura Pritschet, Caitlin M. Taylor, Daniela Cossio

et al.

Nature Neuroscience, Journal Year: 2024, Volume and Issue: 27(11), P. 2253 - 2260

Published: Sept. 16, 2024

Abstract Pregnancy is a period of profound hormonal and physiological changes experienced by millions women annually, yet the neural unfolding in maternal brain throughout gestation are not well studied humans. Leveraging precision imaging, we mapped neuroanatomical an individual from preconception through 2 years postpartum. Pronounced decreases gray matter volume cortical thickness were evident across brain, standing contrast to increases white microstructural integrity, ventricle cerebrospinal fluid, with few regions untouched transition motherhood. This dataset serves as comprehensive map human gestation, providing open-access resource for imaging community further explore understand brain.

Language: Английский

Citations

21
The multi-stage plasticity in the aggression circuit underlying the winner effect DOI
Rongzhen Yan,

Dongyu Wei,

Avni Varshneya

et al.

Cell, Journal Year: 2024, Volume and Issue: 187(24), P. 6785 - 6803.e18

Published: Oct. 14, 2024

Language: Английский

Citations

9
Pregnancy entails a U-shaped trajectory in human brain structure linked to hormones and maternal attachment DOI Creative Commons
Camila Servin-Barthet, Magdalena Martínez‐García, María Paternina-Die

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 16, 2025

Growing evidence places the gestational period as a unique moment of heightened neuroplasticity in adult life. In this longitudinal study spanning pre, during, and post pregnancy, we unveil U-shaped trajectory gray matter (GM) volume, which dips late pregnancy partially recovers during postpartum. These changes are most prominent brain regions associated with Default Mode Frontoparietal Network. The is predominantly linked to factors, it only presents mothers correlates fluctuations estrogens over time. Finally, mother's mental health status mediates relationship between postpartum GM volume recovery maternal attachment at 6 months This research sheds light on complex interplay hormones, development, behavior transition motherhood. It addresses significant knowledge gap neuroscience human opens new possibilities for interventions aimed enhancing well-being.

Language: Английский

Citations

1
The dual ECL signal enhancement strategy of Pd nanoparticles attached covalent organic frameworks and exonuclease cycling reaction for the ultrasensitive detection of progesterone DOI

Jin-Jie Pan,

Hao-Tian Zhu,

Jun Chen

et al.

Talanta, Journal Year: 2024, Volume and Issue: 274, P. 125934 - 125934

Published: April 3, 2024

Language: Английский

Citations

8
Pregnancy Entails a U-Shaped Trajectory in Human Brain Structure Linked to Hormones and Maternal Attachment DOI Creative Commons

Camila Servin-Barthet,

Magdalena Martínez‐García, María Paternina-Die

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: March 29, 2024

Abstract Growing evidence places the gestational period as a unique moment of heightened neuroplasticity in adult life. In this longitudinal study, we unveiled U-shaped trajectory gray matter (GM) volume, which dips late pregnancy and partially recovers during postpartum. These changes were most prominent brain regions associated with Default Mode Frontoparietal Network, also showed an increased global efficiency density connectivity. The was predominantly linked to factors, it only present mothers correlated fluctuations estrogens over time. Finally, mother’s mental health status mediated relationship between postpartum GM volume recovery maternal attachment at six months This research sheds light on complex interplay hormones, development, behavior transition motherhood. It addresses significant knowledge gap neuroscience human opens new possibilities for interventions aimed enhancing well-being.

Language: Английский

Citations

5
Neurobiological Changes Across Pregnancy: A Longitudinal Investigation DOI Open Access
Yanbin Niu, Benjamin Conrad, M. Catalina Camacho

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 8, 2024

Pregnancy is a period of profound biological transformation. However, we know remarkably little about pregnancy-related brain changes. To address this gap, chart longitudinal changes in structure during pregnancy and explore potential mechanisms driving these Ten participants (Mean age = 28.97 years) are assessed 1-6 times (median 3) their pregnancy. Each visit includes anatomical diffusion-weighted MRI, assessments waking salivary hormones, hair inflammatory cytokines. Here observe reduction gray matter volume gestational week, while neurite density index (NDI), proxy axon density, white tracts increase across Progesterone levels associated with reductions volumetric measurements, both progesterone estradiol linked to increases NDI tracts. This study highlights the neurobiological experienced by pregnant individuals provides insights into neuroplasticity adulthood.

Language: Английский

Citations

4
Reproductive function and behaviors: an update on the role of neural estrogen receptors alpha and beta DOI Creative Commons

Thomas Zurga Markus Torres,

Nolwenn Adam, Sakina Mhaouty‐Kodja

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: June 24, 2024

Infertility is becoming a major public health problem, with increasing frequency due to medical, environmental and societal causes. The increasingly late age of childbearing, growing exposure endocrine disruptors other reprotoxic products, number medical reproductive dysfunctions (endometriosis, polycystic ovary syndrome, etc.) are among the most common Fertility relies on fine-tuned control both neuroendocrine function behaviors, those critically regulated by sex steroid hormones. Testosterone estradiol exert organizational activational effects throughout life establish activate neural circuits underlying function. This regulation mediated through estrogen receptors (ERs) androgen receptor (AR). Estradiol acts mainly via nuclear ERα ERβ. aim this review summarize genetic studies that have been undertaken comprehend specific contribution ERβ in hypothalamic-pituitary-gonadal axis expression including sexual parental behavior. Particular emphasis will be placed role these differences.

Language: Английский

Citations

4
Parenting: How caregiving experience refines sensory integration DOI
Anita E. Autry

Current Biology, Journal Year: 2025, Volume and Issue: 35(1), P. R24 - R26

Published: Jan. 1, 2025

Language: Английский

Citations

0
Longitudinal investigation of neurobiological changes across pregnancy DOI Creative Commons
Yanbin Niu, Benjamin Conrad, M. Catalina Camacho

et al.

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: Jan. 18, 2025

Pregnancy is a period of profound biological transformation. However, we know remarkably little about pregnancy-related brain changes. To address this gap, chart longitudinal changes in structure during pregnancy and explore potential mechanisms driving these Ten participants (Mean age = 28.97 years) are assessed 1-6 times (median 3) their pregnancy. Each visit includes anatomical diffusion-weighted MRI, assessments waking salivary hormones, hair inflammatory cytokines. Here observe reduction gray matter volume an increase neurite density index (NDI), proxy axon density, white tracts across Progesterone levels associated with reductions volumetric measurements, both progesterone estradiol linked to increases NDI tracts. This study highlights the neurobiological experienced by pregnant individuals provides insights into neuroplasticity adulthood.

Language: Английский

Citations

0
The microbiome as a modulator of neurological health across the maternal-offspring interface DOI Creative Commons
Stephanie B. Orchanian, Elaine Y. Hsiao

Journal of Clinical Investigation, Journal Year: 2025, Volume and Issue: 135(4)

Published: Feb. 16, 2025

The maternal microbiome is emerging as an important factor that influences the neurological health of mothers and their children. Recent studies highlight how microbial communities in gut can shape early-life development ways inform long-term trajectories. Research on neurodevelopmental effects microbiomes expanding our understanding microbiome-gut-brain axis to include signaling across maternal-offspring unit during perinatal period. In this Review, we synthesize existing literature modulates brain function behavior both developing offspring. We present evidence from human animal showing interacts with environmental factors impact risk for abnormalities. further discuss molecular cellular mechanisms facilitate crosstalk neuromodulation. Finally, consider advancing these complex interactions could lead microbiome-based interventions promoting offspring health.

Language: Английский

Citations

0