The selfish yet forgetful brain: Stable cerebral oxygen metabolism during hypoglycemia but impaired memory consolidation DOI Open Access
Antonia Bose, Stefanie J. Haschka, Johanna Koehler

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract The continuous supply of glucose and oxygen is essential for healthy brain function. Accordingly, the Selfish Brain Theory proposes that human prioritizes its own energy demands, making it less vulnerable to fluctuations in systemic availability. Although studies have reported decreases cerebral metabolism, alternative sources other than might be oxidized ATP production. However, metabolism (CMR O2 ) has never been quantified across brain. In this study, we investigated influence insulin-induced hypoglycemia on CMR male participants. Additionally, explored prolonged effects cognitive function following restoration euglycemia. We found remained stable under hypoglycemia, even at blood levels below 49 mg/dL. Interestingly, detected a significant increase flow (CBF) up 11%, particularly regions involved higher processing. Despite rates identified selective impairment memory consolidation after normal were restored, with no observed encoding or attention. favor Theory, stability suggests efficiently shifts alternate pathways potentially using astrocytic glycogen. metabolic flexibility, our results indicate prior imposes long-lasting consolidation, possibly linked glycogen depletion impaired glutamate synthesis. summary, study clinical states pose critical impact patients’ health functioning.

Language: Английский

Spindle-locked ripples mediate memory reactivation during human NREM sleep DOI Creative Commons
Thomas Schreiner, Benjamin Griffiths,

Merve Kutlu

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: June 19, 2024

Abstract Memory consolidation relies in part on the reactivation of previous experiences during sleep. The precise interplay sleep-related oscillations (slow oscillations, spindles and ripples) is thought to coordinate information flow between relevant brain areas, with ripples mediating memory reactivation. However, humans empirical evidence for a role lacking. Here, we investigated relevance sleep specifically human using targeted Intracranial electrophysiology epilepsy patients scalp EEG healthy participants revealed that elevated levels slow oscillation - spindle activity coincided read-out experimentally induced Importantly, spindle-locked recorded intracranially from medial temporal lobe were found be correlated identification non-rapid eye movement Our findings establish as key-oscillation emphasize importance coordinated cardinal oscillations.

Language: Английский

Citations

10

Hippocampal neuronal activity is aligned with action plans DOI Creative Commons
Ipshita Zutshi, Athina Apostolelli, Wannan Yang

et al.

Nature, Journal Year: 2025, Volume and Issue: 639(8053), P. 153 - 161

Published: Jan. 8, 2025

Language: Английский

Citations

2

Spatiotemporal Patterns Differentiate Hippocampal Sharp-Wave Ripples from Interictal Epileptiform Discharges in Mice and Humans DOI Open Access
Anna Maslarova, Jiyun N. Shin, Andrea Navas-Olivé

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Abstract Hippocampal sharp-wave ripples (SPW-Rs) are high-frequency oscillations critical for memory consolidation in mammals. Despite extensive characterization rodents, their application as biomarkers to track and treat dysfunction humans is limited by coarse spatial sampling, interference from interictal epileptiform discharges (IEDs), lack of consensus on human SPW-R localization morphology. We demonstrate that mouse hippocampal share spatial, spectral temporal features, which clearly distinct IEDs. In 1024-channel recordings APP/PS1 mice, SPW-Rs were distinguishable IEDs narrow the CA1 pyramidal layer, narrowband frequency peaks, multiple ripple cycles unfiltered local field potential. epilepsy patients, showed similar peaks visible subiculum but absent dentate gyrus. Conversely, a broad extent wide-band power. introduce semi-automated, detection toolbox (“ripmap”) selecting optimal channels separating event waveforms low-dimensional embedding. Our approach improves accuracy, providing firm foundation future research.

Language: Английский

Citations

1

Analysis methods for large-scale neuronal recordings DOI
Carsen Stringer, Marius Pachitariu

Science, Journal Year: 2024, Volume and Issue: 386(6722)

Published: Nov. 7, 2024

Simultaneous recordings from hundreds or thousands of neurons are becoming routine because innovations in instrumentation, molecular tools, and data processing software. Such can be analyzed with science methods, but it is not immediately clear what methods to use how adapt them for neuroscience applications. We review, categorize, illustrate diverse analysis neural population describe these have been used make progress on longstanding questions neuroscience. review a variety approaches, ranging the mathematically simple complex, exploratory hypothesis-driven, recently developed more established methods. also some common statistical pitfalls analyzing large-scale data.

Language: Английский

Citations

4

Temporal information in the anterior cingulate cortex relates to accumulated experiences DOI

Ryan A. Wirt,

Talha K. Soluoku,

Ryan M. Ricci

et al.

Current Biology, Journal Year: 2024, Volume and Issue: 34(13), P. 2921 - 2931.e3

Published: June 21, 2024

Language: Английский

Citations

3

Memory consolidation from a reinforcement learning perspective DOI Creative Commons

Jong Won Lee,

Min Whan Jung

Frontiers in Computational Neuroscience, Journal Year: 2025, Volume and Issue: 18

Published: Jan. 8, 2025

Memory consolidation refers to the process of converting temporary memories into long-lasting ones. It is widely accepted that new experiences are initially stored in hippocampus as rapid associative memories, which then undergo a establish more permanent traces other regions brain. Over past two decades, studies humans and animals have demonstrated crucial not only for memory but also imagination future planning, with CA3 region playing pivotal role generating novel activity patterns. Additionally, growing body evidence indicates involvement hippocampus, especially CA1 region, valuation processes. Based on these findings, we propose generates diverse patterns, while evaluates reinforces those patterns most likely maximize rewards. This framework closely parallels Dyna, reinforcement learning algorithm introduced by Sutton 1991. In an agent performs offline simulations supplement trial-and-error value learning, greatly accelerating process. We suggest might be viewed deriving optimal strategies based derived from limited experiences, rather than merely strengthening incidental memories. From this perspective, functions form aimed at enhancing adaptive decision-making.

Language: Английский

Citations

0

Could sleep be a brain/cognitive/neural reserve-builder factor? A systematic review on the cognitive effects of sleep modulation in animal models DOI
Francesca Balsamo, Debora Meneo, Erica Berretta

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 106015 - 106015

Published: Jan. 1, 2025

Language: Английский

Citations

0

Event boundaries drive norepinephrine release and distinctive neural representations of space in the rodent hippocampus DOI Open Access
Sam McKenzie,

Alexandra L. Sommer,

Tia N. Donaldson

et al.

Published: Jan. 31, 2025

Episodic memories are temporally segmented around event boundaries that tend to coincide with moments of environmental change. During these times, the state brain should change rapidly, or reset, ensure information encountered before and after an boundary is encoded in different neuronal populations. Norepinephrine (NE) thought facilitate this network reorganization. However, it unknown whether drive NE release hippocampus and, if so, how relates changes hippocampal firing patterns. The advent new GRAB sensor now allows for measurement binding sub-second resolution. Using tool mice, we tested released into dorsal during defined by unexpected transitions between spatial contexts presentations novel objections. We found dynamics were well explained time elapsed each changes, not related conditioned behaviors, exploratory bouts movement, reward. Familiarity a context accelerated rate which phasic decayed baseline. Knowing when elevated, coding space differs moments. Immediately observed relatively unique patterns neural spiking settled modal at similar returned These results consistent model wherein drives representations away from steady-state attractor. hypothesize distinctive codes may long-term memory contribute basis primacy effect.

Language: Английский

Citations

0

Event boundaries drive norepinephrine release and distinctive neural representations of space in the rodent hippocampus DOI Open Access
Sam McKenzie,

Alexandra L. Sommer,

Tia N. Donaldson

et al.

Published: Jan. 31, 2025

Episodic memories are temporally segmented around event boundaries that tend to coincide with moments of environmental change. During these times, the state brain should change rapidly, or reset, ensure information encountered before and after an boundary is encoded in different neuronal populations. Norepinephrine (NE) thought facilitate this network reorganization. However, it unknown whether drive NE release hippocampus and, if so, how relates changes hippocampal firing patterns. The advent new GRAB sensor now allows for measurement binding sub-second resolution. Using tool mice, we tested released into dorsal during defined by unexpected transitions between spatial contexts presentations novel objections. We found dynamics were well explained time elapsed each changes, not related conditioned behaviors, exploratory bouts movement, reward. Familiarity a context accelerated rate which phasic decayed baseline. Knowing when elevated, coding space differs moments. Immediately observed relatively unique patterns neural spiking settled modal at similar returned These results consistent model wherein drives representations away from steady-state attractor. hypothesize distinctive codes may long-term memory contribute basis primacy effect.

Language: Английский

Citations

0

Dynamics of hippocampal reactivation for temporal association memory in mice DOI
Hui Chen, Bin Wang, Yue Zhan

et al.

Progress in Neurobiology, Journal Year: 2025, Volume and Issue: unknown, P. 102729 - 102729

Published: Feb. 1, 2025

Language: Английский

Citations

0