Metabolic Reprogramming in Gut Microbiota Exposed to Polystyrene Microplastics DOI Creative Commons

Jinhua Chi,

Jeffrey Patterson, Yan Jin

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 446 - 446

Published: Feb. 12, 2025

Background: Microplastics (MPs) are small plastic fragments with diameters less than 5 mm in size and prevalent everyday essentials consumables. Large global production has now led to a flooding of MPs our natural environment. Due their detrimental impacts on the planet's ecosystems potentially health, have emerged as significant public health concern. In this pilot study, we hypothesize that exposure will negatively affect gut microbiota composition function, which metabolic reprogramming plays an important role. Methods: Using vitro experiments, three bacterial strains (Escherichia coli MG1655, Nissle 1917, Lactobacillus rhamnosus) were selected investigate exposure. The individually cultured anaerobic chamber exposed 1 µm polystyrene at various concentrations (0, 10, 20, 50, 100, 500 µg/mL) culture medium. Results: reduced growth all dose-dependent manner. Liquid chromatography mass spectrometry (LC-MS)-based untargeted metabolomics revealed differences multiple pathways, such sulfur metabolism amino sugar nucleotide metabolism. addition, extracted from C57BL/6 mice, 16S rRNA sequencing results showed upregulation Lactobacillales reduction Erysipelotrichales due Furthermore, targeted corroborated alterations microbial tryptophan energy producing glycolysis/gluconeogenesis pentose phosphate pathway. Conclusions: These findings provide evidence causes comprehensive changes healthy microbiota, may also insights into mechanistic effects humans.

Language: Английский

Influence of mesh selectivity on risk assessment of marine microplastics DOI
Zijiang Yang, Jiaqi Zhang, Voranop Viyakarn

et al.

Marine Pollution Bulletin, Journal Year: 2025, Volume and Issue: 212, P. 117538 - 117538

Published: Jan. 9, 2025

Language: Английский

Citations

4
Microplastics enhance the prevalence of antibiotic resistance genes in mariculture sediments by enriching host bacteria and promoting horizontal gene transfer DOI Creative Commons
Yifan Liu, Liuqingqing Liu, Xiao Wang

et al.

Eco-Environment & Health, Journal Year: 2025, Volume and Issue: unknown, P. 100136 - 100136

Published: Jan. 1, 2025

Microplastics (MPs) and antibiotic resistance genes (ARGs) pose significant challenges to the One Health framework due their intricate multifaceted ecological environmental impacts. However, understanding of how MP properties influence ARG prevalence in mariculture sediments remains limited. Herein, polystyrene (PS) polyvinyl chloride (PVC) MPs with different sizes (20-120 μm 0.5-2.0 mm) were selected evaluate impacts underlying mechanisms driving ARGs dissemination. The results showed that PS PVC increased relative abundance by 1.41-2.50-fold 2.01-2.84-fold, respectively, compared control, particularly high-risk genes. polymer type effect was identified as more influential than size sediment resistome evolution. shifted microbial community assembly from stochastic deterministic processes, thus enriching host pathogens. Furthermore, highly hydrophobic not only recruited bacteria colonization but also facilitated exchange within plastisphere. exogenous additives released (e.g., heavy metals, bisphenol A, tridecyl ester) particles synergistically promoted conjugative transfer inducing oxidative stress enhancing cell membrane permeability. These findings revealed characteristics spread marine benthic ecosystems, underscoring importance mitigating pollution maintain ecosystem health, prevent zoonotic diseases, balance global health.

Language: Английский

Citations

4
Human microplastic removal: what does the evidence tell us? DOI Open Access
Nicholas Fabiano, Brandon Luu, David Puder

et al.

Brain medicine :, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 2

Published: March 4, 2025

The increased levels of microplastics and nanoplastics (MNPs) found in human brain tissue are alarming, particularly patients with dementia. Although total avoidance MNP exposure will likely remain an unattainable endpoint light their ubiquity the environment, new studies indicate feasible pathways by which dietary intake may be decreased or clearances improved. This commentary reviews evidence on to MNPs, penetration, potential health effects, neurotoxicity. We explore evidence-based strategies for reducing through lifestyle changes while addressing key gaps our current knowledge calling additional research.

Language: Английский

Citations

4
Biochar-mediated remediation of low-density polyethylene microplastic-polluted soil-plant systems: Role of phosphorus and protist community responses DOI

Qi-Lu Zhuang,

Haiyan Yuan,

Min Sun

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 486, P. 137076 - 137076

Published: Jan. 6, 2025

Language: Английский

Citations

3
A screening method for polyester films-degrading microorganisms and enzymes DOI Creative Commons
Nina Urbelienė,

Renata Gasparavičiūtė,

Justas Vaitekūnas

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 487, P. 137177 - 137177

Published: Jan. 10, 2025

Enzymatic degradation of plastic pollution offers a promising environmentally friendly waste management strategy, however, suitable biocatalysts must be screened and developed. Traditional screening methods using soluble or solubilised polymers do not necessarily identify enzymes that are effective against solid crystalline polymers. This study presents simple, time-saving cost-effective method for identifying microorganisms capable degrading polymeric films. The was tested on polycaprolactone (PCL), polyethylene terephthalate (PET), polylactate (PLA) polyhydroxybutyrate/polyhydroxyvalerate (PHB/PHV) It involves two steps: first, PCL diol (PCLD)-degrading agar plates, second, testing these polyester Using this method, over 100 PCLD-degrading 27 E. coli clones carrying genomic metagenomic DNA fragments have been isolated. In addition, recombinant cutinases from Streptomyces scabiei Thermobifida fusca tested. Approximately 66 % the forming halos PCLD plates hydrolysed 6 - biaxially oriented PET film. five PLA- four PHB/PHV-degrading esterases identified. proposed is detecting both wild-type microorganisms, as well in vitro transcription-translation reactions. Screening thermostable thermophilic enzymes, including those resistant to organic solvents environmental inhibitors, also easily implemented.

Language: Английский

Citations

3
Polylactic Acid Micro/Nanoplastic Exposure Induces Male Reproductive Toxicity by Disrupting Spermatogenesis and Mitochondrial Dysfunction in Mice DOI
Qiancheng Zhao, Zishui Fang, Pengcheng Wang

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Although considered an "eco-friendly" biodegradable plastic, polylactic acid (PLA) microplastic (PLA-MP) poses a growing concern for human health, yet its effects on male reproductive function remain underexplored. This study investigated the toxicity of PLA in mice and potential mechanisms. To this end, our vivo vitro experiments demonstrated that after degradation digestive system, significant number PLA-MP-derived nanoparticles could penetrate blood–testis barrier (BTB) localize within spermatogenic microenvironment. Mice exposed to PLA-MPs long time exhibited toxicity, evidenced by decreased sperm concentration motility, increased deformity rates, disrupted sex hormone levels. Further analysis revealed impaired BTB, induced mitochondrial dysfunction testes, triggered oxidative stress through excessive ROS production from mitochondria, leading further testicular damage. Notably, nanoplastics internalized sheath structure sperm, causing dose-dependent impairments function. Transcriptome analyses indicated spermatogenesis inhibiting expression key mRNA involved process. Collectively, findings highlight toxic effect damaging BTB impairing function, which provides insights into toxicological implications microplastics mammalian fertility.

Language: Английский

Citations

3
Mechanistic applications of low-temperature plasma in starch-based biopolymer film: A review DOI

Yanli Guo,

Mengzhuo Liu,

Rui Chuang

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: 479, P. 143739 - 143739

Published: March 5, 2025

Language: Английский

Citations

3
Insights into effects of drying–wetting cycles on dissolved organic matter and Cd bioavailability in riparian sediments amended with microplastics. DOI
Si Liu, Jinhui Huang,

Wenjuan He

et al.

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121087 - 121087

Published: Feb. 1, 2025

Language: Английский

Citations

2
Microplastics abundance associated with farmland use types and the impact on soil microbial communities: A case study in Southern China DOI
Quanyun Ye,

Yingxin Wu,

Xucheng Liu

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 136477 - 136477

Published: Nov. 12, 2024

Language: Английский

Citations

10
Imperfect wound healing sets the stage for chronic diseases DOI
Paul Martin, Carlos Pardo-Pastor, Gisli Jenkins

et al.

Science, Journal Year: 2024, Volume and Issue: 386(6726)

Published: Dec. 5, 2024

Although the age of genome gave us much insight about how our organs fail with disease, it also suggested that diseases do not arise from mutations alone; rather, they develop as we age. In this Review, examine wound healing might act to ignite disease. Wound works well when are younger, repairing damage accidents, environmental assaults, and battles pathogens. Yet, accumulation tissue damage, repair process can devolve, leading inflammation, fibrosis, neoplastic signaling. We discuss healthy responses bodies misappropriate these pathways in focus predominantly on epithelial-based (lung skin) diseases, similar operate cardiac, muscle, neuronal diseases.

Language: Английский

Citations

10