Giant Polyketide Synthases Biosynthesize a Marine Polyether Biotoxin DOI
Robin Teufel, Michael Müller

Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Abstract Prymnesin toxins were probably the direct cause of environmental catastrophe in Oder river 2022. They belong to so‐called ladder polyethers, which are among most toxic non‐proteinogenic substances and have caused a whole series food poisoning humans numerous other incidents fish deaths. Despite massive efforts, enzymatic machinery has remained enigmatic. In recent study, researchers at Scripps Institution Oceanography University California, San Diego, uncovered initial mechanisms by algae produce these toxins. Crucial breakthrough was methodological advance sequencing assembly that allowed identification analysis largest polyketide synthase (PKS) known date, named PKZILLA‐1 PKZILLA‐2, enabled, things, confirmation elucidation stereocenters. Thus, further investigations into biosynthesis aspects highly made possible, could perhaps make ′biblical plagues′ predictable.

Language: Английский

Wie Goldalgen ihre Toxine produzieren DOI

Annette Hille-Rehfeld

Chemie in unserer Zeit, Journal Year: 2025, Volume and Issue: 59(1), P. 7 - 9

Published: Feb. 1, 2025

Vermittelt durch hochmolekulare Toxine, die Prymnesine, führte massive Vermehrung der Goldalge Prymnesium parvum im Sommer 2022 zu einem katastrophalen Fischsterben in Oder. Die Biosynthese Prymnesine bewerkstelligen multifunktionelle Enzyme mit zahlreichen katalytischen Zentren, Polyketid‐Synthasen. Eine Prymnesin‐Synthasen ist größer als das Muskelprotein Titin.

Citations

0
Trendbericht: Organische Chemie 2025 DOI Open Access
Martin Breugst, Jennifer N. Andexer,

Lena Barra

et al.

Nachrichten aus der Chemie, Journal Year: 2025, Volume and Issue: 73(3), P. 40 - 70

Published: Feb. 28, 2025

Abstract Highlights von November 2023 bis 2024: die erste Einelektron‐C–C‐σ‐Bindung und Anti‐Bredt‐Verbindung; gesättigte Heterocyclen elektrochemisch funktionalisieren; Ausrichten diskotischer Flüssigkristalle; enantioselektive Wagner‐Meerwein‐Umlagerung reiner Aliphaten; photokatalytisch Furanen zu Pyrrolen; mit Ammoniak primären Arylaminen; Metallschrott recyceln ionischen Flüssigkeiten; terminale Alkene Ni‐Katalysatoren zum (Z)‐ oder (E)‐Alken isomerisieren;neue Fungizide, Medikamente Alkaloide.

Citations

0
Design principles imprinted by evolution DOI
Martin Grininger

Nature Chemical Biology, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Language: Английский

Citations

0
The Chemistry of Phytoplankton DOI Creative Commons
Xiaoying Liu, Zhiwei Bian,

Shian Hu

et al.

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(23), P. 13099 - 13177

Published: Nov. 21, 2024

Phytoplankton have a high potential for CO2 capture and conversion. Besides being vital food source at the base of oceanic freshwater webs, microalgae provide critical platform producing chemicals consumer products. Enhanced nutrient levels, elevated CO2, rising temperatures increase frequency algal blooms, which often negative effects such as fish mortalities, loss flora fauna, production toxins. Harmful blooms (HABs) produce toxins that pose major challenges to water quality, ecosystem function, human health, tourism, web. These complex chemical structures possess wide range biological properties with applications new therapeutics. This review presents balanced comprehensive assessment roles in generating fixed carbon chain, sequestering carbon, their unique secondary metabolites. The structural complexity these metabolites has had an unprecedented impact on structure elucidation technologies total synthesis, are highlighted throughout this review. In addition, influence biogeochemical environmental perturbations biospheric environments is discussed. Lastly, we summarize work management strategies control treatment HABs.

Language: Английский

Citations

2
Influence of nitrate and salinity on growth and toxin production of Prymnesium parvum DOI

W.D Yan,

Guixiang Wang, Ying Ji

et al.

Harmful Algae, Journal Year: 2024, Volume and Issue: 140, P. 102760 - 102760

Published: Nov. 18, 2024

Language: Английский

Citations

2
The chemical ecology and physiological functions of type I polyketide natural products: the emerging picture DOI
R François,

Jean-Malo Massicard,

Kira J. Weissman

et al.

Natural Product Reports, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

Covering: up to 2024.For many years, the value of complex polyketides lay in their medical properties, including antibiotic and antifungal activities, with little consideration paid native functions. However, more recent evidence gathered from study inter-organismal interactions has revealed influence these metabolites upon ecological adaptation distribution hosts, as well modes communication. The increasing number sequenced genomes associated transcriptomes also unveiled widespread occurrence underlying biosynthetic enzymes across all kingdoms life, important contributions they make physiological events specific each organism. This review depicts diversity roles fulfilled by type I polyketides, particularly light studies carried out during last decade, providing an initial overall picture diverse

Language: Английский

Citations

1
Notizen aus der Forschung DOI

Lena Barra,

Céline Calviño, Georg Dierkes

et al.

Nachrichten aus der Chemie, Journal Year: 2024, Volume and Issue: 72(10), P. 48 - 51

Published: Sept. 30, 2024

Citations

0
Giant Polyketide Synthases Biosynthesize a Marine Polyether Biotoxin DOI
Robin Teufel, Michael Müller

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Abstract Prymnesin toxins were probably the direct cause of environmental catastrophe in Oder river 2022. They belong to so‐called ladder polyethers, which are among most toxic non‐proteinogenic substances and have caused a whole series food poisoning humans numerous other incidents fish deaths. Despite massive efforts, enzymatic machinery has remained enigmatic. In recent study, researchers at Scripps Institution Oceanography University California, San Diego, uncovered initial mechanisms by algae produce these toxins. Crucial breakthrough was methodological advance sequencing assembly that allowed identification analysis largest polyketide synthase (PKS) known date, named PKZILLA‐1 PKZILLA‐2, enabled, things, confirmation elucidation stereocenters. Thus, further investigations into biosynthesis aspects highly made possible, could perhaps make ′biblical plagues′ predictable.

Language: Английский

Citations

0
Giant Polyketide Synthases Biosynthesize a Marine Polyether Biotoxin DOI
Robin Teufel, Michael Müller

Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Abstract Prymnesin toxins were probably the direct cause of environmental catastrophe in Oder river 2022. They belong to so‐called ladder polyethers, which are among most toxic non‐proteinogenic substances and have caused a whole series food poisoning humans numerous other incidents fish deaths. Despite massive efforts, enzymatic machinery has remained enigmatic. In recent study, researchers at Scripps Institution Oceanography University California, San Diego, uncovered initial mechanisms by algae produce these toxins. Crucial breakthrough was methodological advance sequencing assembly that allowed identification analysis largest polyketide synthase (PKS) known date, named PKZILLA‐1 PKZILLA‐2, enabled, things, confirmation elucidation stereocenters. Thus, further investigations into biosynthesis aspects highly made possible, could perhaps make ′biblical plagues′ predictable.

Language: Английский

Citations

0