Novel insights into the sexual dimorphism-associated immune response DOI
José M. Izquierdo

Cellular and Molecular Immunology, Journal Year: 2024, Volume and Issue: 21(8), P. 804 - 806

Published: May 13, 2024

Language: Английский

Intestinal estrogen receptor beta modulates the murine colon tumor immune microenvironment DOI Creative Commons
Madeleine Birgersson, Matilda Holm, Carlos J. Gallardo-Dodd

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217661 - 217661

Published: March 1, 2025

Language: Английский

Citations

0
Natural Matrine‐Integrated Pollen Delivery Systems for Allergic Contact Dermatitis Treatment DOI Creative Commons
Yuwei Wang, Lijun Cai, Yuanyuan Zhang

et al.

Smart Medicine, Journal Year: 2025, Volume and Issue: 4(1)

Published: Feb. 26, 2025

Allergic contact dermatitis (ACD) is an inflammatory with a high morbidity and recurrence rate. Scientific attention focused on the development of safe comfortable therapeutics ACD. Herein, we propose natural matrine-integrated pollen delivery system for ACD treatment. Sunflower pollens were collected defatted to serve as adhesive drug carriers matrine. Specifically, exquisite porous hollow structures shells can absorb matrine realize sustained release. Besides, prickly surface morphology strongly adhere inflamed skin sites, which prolong duration drug. By utilizing them in model acute pruritus mice, have demonstrated that these decrease swelling degree mice ears weight loss, down-regulate response, improve scratching times. These results indicate our systems great potential topical preparations disease therapy.

Language: Английский

Citations

0
Sex differences and testosterone interfere with the structure of the gut microbiota through the bile acid signaling pathway DOI Creative Commons
Xueqing Duan, You-Qi Nie, Xin Xie

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 18, 2024

Background The gut microbiome has a significant impact on human wellness, contributing to the emergence and progression of range health issues including inflammatory autoimmune conditions, metabolic disorders, cardiovascular problems, psychiatric disorders. Notably, clinical observations have revealed that these illnesses can display differences in incidence presentation between genders. present study aimed evaluate whether composition microbiota is associated with sex-specific elucidate mechanism. Methods 16S-rRNA-sequencing technology, hormone analysis, transplantation, gonadectomy, treatment were employed investigate correlation sex or hormones. Meanwhile, genes proteins involved bile acid signaling pathway analyzed both liver ileum tissues. Results diversity from jejunum feces level hormones serum differed sexes young middle-aged Sprague Dawley (SD) rats. However, no similar phenomenon was found geriatric Interestingly, young, middle-aged, old rats, bacterial Gut replacement also suggested hormones, particularly testosterone (T), influenced mRNA protein (specifically SHP , FXR CYP7A1 ASBT ) exhibited gender-specific differences, T may play role mediating expression this pathway. Conclusion Sex-specific structure are mediated by through pathway, pointing potential targets for disease prevention management techniques indicating levels alter via

Language: Английский

Citations

0
Novel insights into the sexual dimorphism-associated immune response DOI
José M. Izquierdo

Cellular and Molecular Immunology, Journal Year: 2024, Volume and Issue: 21(8), P. 804 - 806

Published: May 13, 2024

Language: Английский

Citations

0