Enhancer-driven cell type comparison reveals similarities between the mammalian and bird pallium

Science, Journal Year: 2025, Volume and Issue: 387(6735)

Published: Jan. 2, 2025

Combinations of transcription factors govern the identity cell types, which is reflected by genomic enhancer codes. We used deep learning to characterize these codes and devised three metrics compare types in telencephalon across amniotes. To this end, we generated single-cell multiome spatially resolved transcriptomics data chicken telencephalon. Enhancer orthologous nonneuronal γ-aminobutyric acid–mediated (GABAergic) show a high degree similarity amniotes, whereas excitatory neurons mammalian neocortex avian pallium exhibit varying degrees similarity. mesopallial are most similar those deep-layer neurons. With study, present generally applicable approaches on basis regulatory sequences.

Language: Английский

Constrained roads to complex brains

Science, Journal Year: 2025, Volume and Issue: 387(6735), P. 716 - 717

Published: Jan. 2, 2025

Neural development and brain circuit evolution converged in birds mammals

Language: Английский

How do big brains evolve?

Trends in Ecology & Evolution, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский