Cited by The modulation of cholecystokinin receptor 1 in the NAc core input from VTA on METH-induced CPP acquisition

Study on the Vocal Fold Movement Characteristics of Canine Models With Nerve Paralysis Caused by Different Site Injuries DOI

Mei Shi,

Linlin Lan,

Peiyun Zhuang

et al.

World Journal of Otorhinolaryngology - Head and Neck Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Language: Английский

Citations

From valence encoding to motivated behavior: a focus on the nucleus accumbens circuitry DOI

Natacha Vieitas‐Gaspar, Carina Soares‐Cunha, Ana João Rodrigues

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 106125 - 106125

Published: March 1, 2025

How do our brains determine whether something is good or bad? The brain's ability to evaluate stimuli as positive negative - by attributing valence fundamental survival and decision-making. Different brain regions have been associated with encoding, including the nucleus accumbens (NAc). NAc predominantly composed of GABAergic medium spiny neurons (MSNs), which segregate into two distinct populations based on their dopamine receptor expression: D1-receptor-expressing (D1-MSNs) D2-receptor-expressing (D2-MSNs). Classical models propose a binary functional role, where D1-MSNs exclusively mediated reward valence, while D2-MSNs processed aversion valence. However, we now recognize that MSN subpopulations operate in more complex manner than previously thought, often working cooperatively rather antagonistically valence-related behaviors. This review synthesizes current knowledge valence-encoding neurocircuitry, emphasis NAc. We examine electrophysiological, calcium imaging, optogenetic, chemogenetic pharmacological studies detailing contribution for rewarding aversive responses. Finally, explore emerging technical innovations promise advance understanding how mammalian encodes translates it behavior.

Language: Английский

Citations

Neuromodulatory signaling contributing to the encoding of aversion DOI

Cheng-Hsi Wu,

Léa Camelot,

Salvatore Lecca

et al.

Trends in Neurosciences, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

The appropriate and rapid encoding of stimuli bearing a negative valence enables behaviors that are essential for survival. Recent advances in neuroscience using rodents as model system highlight the relevance cell type-specific neuronal activities diverse brain networks aversion, well their importance subsequent behavioral strategies. Within these networks, neuromodulators influence excitability, adjust fast synaptic neurotransmission, affect plasticity, ultimately modulating behaviors. In this review we first discuss contemporary findings leveraging use cutting-edge neurotechnologies to define aversion-related neural circuits. spatial temporal dynamics release neuropeptides upon exposure aversive described within defined Together, mechanistic insights update present framework through which aversion drives motivated

Language: Английский

Citations

The brain bases of emotion generation and emotion regulation DOI

Jinxiao Zhang, Ke Bo, Tor D. Wager

et al.

Trends in Cognitive Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

Subcortical functional connectivity alterations in first-episode medication-naïve adolescents with major depressive disorder DOI

Lei Sun, Zilin Zhou, Ruohan Feng

et al.

European Child & Adolescent Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: June 5, 2025

Language: Английский

Citations

The modulation of cholecystokinin receptor 1 in the NAc core input from VTA on METH-induced CPP acquisition DOI

Jian Wang, Minglong Zhang, Yufei Sun

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 361, P. 123290 - 123290

Published: Dec. 3, 2024

Language: Английский

Citations