Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: March 7, 2025

Abstract Macrophages are immune cells belonging to the mononuclear phagocyte system. They play crucial roles in defense, surveillance, and homeostasis. This review systematically discusses types of hematopoietic progenitors that give rise macrophages, including primitive progenitors, erythro-myeloid stem cells. These have distinct genetic backgrounds developmental processes. Accordingly, macrophages exhibit complex diverse functions body, phagocytosis clearance cellular debris, antigen presentation, response, regulation inflammation cytokine production, tissue remodeling repair, multi-level regulatory signaling pathways/crosstalk involved homeostasis physiology. Besides, tumor-associated a key component TME, exhibiting both anti-tumor pro-tumor properties. Furthermore, functional status is closely linked development various diseases, cancer, autoimmune disorders, cardiovascular disease, neurodegenerative metabolic conditions, trauma. Targeting has emerged as promising therapeutic strategy these contexts. Clinical trials macrophage-based targeted drugs, immunotherapies, nanoparticle-based therapy were comprehensively summarized. Potential challenges future directions targeting also been discussed. Overall, our highlights significance this versatile cell human health which expected inform research clinical practice.

Language: Английский

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Malignant Tumors in Vagal-innervated Organs: Exploring Its Homeostatic Role

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217539 - 217539

Published: Feb. 1, 2025

Language: Английский

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Deciphering Colorectal Cancer–Hepatocyte Interactions: A Multiomics Platform for Interrogation of Metabolic Crosstalk in the Liver–Tumor Microenvironment

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1976 - 1976

Published: Feb. 25, 2025

Metabolic reprogramming is a hallmark of cancer, enabling tumor cells to adapt and exploit their microenvironment for sustained growth. The liver common site metastasis, but the interactions between hepatocytes remain poorly understood. In context these play crucial role in promoting survival progression. This study leverages multiomics coverage via liquid chromatography high-resolution, high-mass-accuracy mass spectrometry-based untargeted metabolomics, 13C-stable isotope tracing, RNA sequencing uncover metabolic impact co-localized primary colon adenocarcinoma cell line, SW480, using 2D co-culture model. profiling revealed disrupted Warburg metabolism with an 80% decrease glucose consumption 94% lactate production by hepatocyte-SW480 co-cultures relative SW480 control cultures. Decreased was coupled alterations glutamine ketone body metabolism, suggesting possible fuel switch upon co-culturing. Further, integrated analysis indicates that disruptions pathways, including nucleoside biosynthesis, amino acids, TCA cycle, correlate altered transcriptional profiles highlight importance redox homeostasis adaptation. Finally, findings were replicated three-dimensional microtissue organoids. Taken together, studies support bioinformatic approach crosstalk discovery potential therapeutic targets preclinical models microenvironment.

Language: Английский

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Integrated bioinformatics analysis to develop diagnostic models for malignant transformation of chronic proliferative diseases

Blood Science, Journal Year: 2025, Volume and Issue: 7(2), P. e00226 - e00226

Published: April 7, 2025

The combined analysis of dual diseases can provide new insights into pathogenic mechanisms, identify novel biomarkers, and develop targeted therapeutic strategies. Polycythemia vera (PV) is a chronic myeloproliferative neoplasm associated with risk acute myeloid leukemia (AML) transformation. However, the nature disease transformation complicates longitudinal high-throughput sequencing studies patients PV before after AML This study aimed to diagnostic model for malignant proliferative diseases, addressing challenges early detection intervention. Integrated public datasets were analyzed differentially expressed genes (DEGs) construct weighted correlation network. Machine-learning algorithms screen potential leading development models. Clinical specimens collected validate gene expression. cMAP molecular docking predicted drugs. In vitro experiments performed assess drug efficacy in cells. CIBERSORT single-cell RNA-sequencing (scRNA-seq) analyses used explore impact hub on tumor microenvironment. We identified 24 shared between AML, which enriched immune-related pathways. Lactoferrin (LTF) G protein-coupled receptor 65 (GPR65) integrated nomogram robust predictive power. vemurafenib inhibited proliferation increased apoptosis TME has linked these biomarkers macrophages. samples confirm LTF GPR65 expression levels. developed that offers avenue diagnosis clinical management AML-related PV.

Language: Английский

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Radiotherapy-induced alterations in tumor microenvironment: metabolism and immunity

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: April 28, 2025

Tumor metabolism plays a pivotal role in shaping immune responses within the tumor microenvironment influencing progression, evasion, and efficacy of cancer therapies. Radiotherapy has been shown to impact both modulation, often inducing activation through damage-associated molecular patterns STING pathway. In this study, we analyse particular characteristics tumour metabolic its effect on microenvironment. We also review changes that are induced by radiotherapy, with focus sensitisation effects radiotherapy. Our aim is contribute development research ideas field radiotherapy metabolic-immunological studies.

Language: Английский

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Unraveling the role of starch- oleic acid - chlorogenic/caffeic acid interactions in improving 3D printing properties of rice flour: A structural correlation study

Food Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 144170 - 144170

Published: April 1, 2025

Language: Английский

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Obesity-associated intratumoral acidity promotes pro-tumorigenic macrophages

Nature reviews. Immunology, Journal Year: 2024, Volume and Issue: 24(12), P. 849 - 849

Published: Oct. 28, 2024

Language: Английский

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Macrophages make “sense” of obesity-driven acidity in the TME

Cell chemical biology, Journal Year: 2024, Volume and Issue: 31(12), P. 2021 - 2023

Published: Dec. 1, 2024

Language: Английский

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