Allergology International,
Journal Year:
2017,
Volume and Issue:
66(4), P. 515 - 522
Published: Aug. 18, 2017
Gut
microbial
ecology
and
function
are
dynamic
in
infancy,
but
stabilized
childhood.
The
'new
friends'
have
a
great
impact
on
the
development
of
digestive
tract
host
immune
system.
In
first
year
life,
especially,
gut
microbiota
dramatically
changes
through
interactions
with
developing
system
gut.
process
establishing
is
affected
by
various
environmental
factors,
potential
to
be
main
determinant
life-long
health.
this
review,
we
summarize
recent
findings
regarding
establishment,
including
importance
factors
related
allergic
diseases
later
life.
New England Journal of Medicine,
Journal Year:
2016,
Volume and Issue:
375(24), P. 2369 - 2379
Published: Dec. 14, 2016
The
large
majority
of
studies
on
the
role
microbiome
in
pathogenesis
disease
are
correlative
and
preclinical;
several
have
influenced
clinical
practice.
Frontiers in Microbiology,
Journal Year:
2016,
Volume and Issue:
7
Published: Feb. 17, 2016
The
colon
is
inhabited
by
a
dense
population
of
microorganisms,
the
so-called
"gut
microbiota,"
able
to
ferment
carbohydrates
and
proteins
that
escape
absorption
in
small
intestine
during
digestion.
This
microbiota
produces
wide
range
metabolites,
including
short
chain
fatty
acids
(SCFA).
These
compounds
are
absorbed
large
bowel
defined
as
1-6
carbon
volatile
which
can
present
straight
or
branched-chain
conformation.
Their
production
influenced
pattern
food
intake
diet-mediated
changes
gut
microbiota.
SCFA
have
distinct
physiological
effects:
they
contribute
shaping
environment,
influence
physiology
colon,
be
used
energy
sources
host
cells
intestinal
also
participate
different
host-signaling
mechanisms.
We
summarize
current
knowledge
about
SCFA,
bacterial
cross-feedings
interactions,
biological
properties
these
metabolites
with
impact
on
human
health.
Signal Transduction and Targeted Therapy,
Journal Year:
2022,
Volume and Issue:
7(1)
Published: April 23, 2022
Abstract
The
role
of
microbiota
in
health
and
diseases
is
being
highlighted
by
numerous
studies
since
its
discovery.
Depending
on
the
localized
regions,
can
be
classified
into
gut,
oral,
respiratory,
skin
microbiota.
microbial
communities
are
symbiosis
with
host,
contributing
to
homeostasis
regulating
immune
function.
However,
dysbiosis
lead
dysregulation
bodily
functions
including
cardiovascular
(CVDs),
cancers,
respiratory
diseases,
etc.
In
this
review,
we
discuss
current
knowledge
how
links
host
or
pathogenesis.
We
first
summarize
research
healthy
conditions,
gut-brain
axis,
colonization
resistance
modulation.
Then,
highlight
pathogenesis
disease
development
progression,
primarily
associated
community
composition,
modulation
response,
induction
chronic
inflammation.
Finally,
introduce
clinical
approaches
that
utilize
for
treatment,
such
as
fecal
transplantation.
Microbiology and Molecular Biology Reviews,
Journal Year:
2017,
Volume and Issue:
81(4)
Published: Nov. 8, 2017
SUMMARY
The
human
gut
microbiota
is
engaged
in
multiple
interactions
affecting
host
health
during
the
host's
entire
life
span.
Microbes
colonize
neonatal
immediately
following
birth.
establishment
and
interactive
development
of
this
early
are
believed
to
be
(at
least
partially)
driven
modulated
by
specific
compounds
present
milk.
It
has
been
shown
that
certain
genomes
infant
commensals,
particular
those
bifidobacterial
species,
genetically
adapted
utilize
glycans
secretory
fluid,
thus
representing
a
very
intriguing
example
host-microbe
coevolution,
where
both
partners
benefit.
In
recent
years,
various
metagenomic
studies
have
tried
dissect
composition
functionality
microbiome
explore
distribution
across
different
ecological
niches
biogeography
corresponding
microbial
consortia,
including
bacteria
viruses,
healthy
ill
subjects.
Such
analyses
linked
features
microbiota/microbiome,
such
as
reduced
diversity
or
aberrant
composition,
intestinal
illnesses
infants
disease
states
manifested
at
later
stages
life,
asthma,
inflammatory
bowel
disease,
metabolic
disorders.
Thus,
growing
number
reported
on
how
composition/development
may
affect
risk
factors
related
adult
conditions.
This
concept
fueled
strategies
shape
based
functional
food
products.
review,
we
describe
microbiota,
mechanisms
drive
its
consortia
molded
natural
artificial
interventions.
Finally,
discuss
relevance
key
players
bifidobacteria,
with
respect
their
role
disease.
Science Translational Medicine,
Journal Year:
2016,
Volume and Issue:
8(343)
Published: June 15, 2016
A
longitudinal
study
of
intestinal
microbiota
in
children
and
their
mothers
shows
that
antibiotics,
cesarean
section,
infant
formula
alter
patterns
microbial
acquisition
succession
during
the
first
2
years
childhood.
