Cellular and Molecular Immunology, Journal Year: 2022, Volume and Issue: 19(7), P. 834 - 847
Published: May 20, 2022
Language: Английский
Hepatology, Journal Year: 2024, Volume and Issue: unknown
Published: Feb. 13, 2024
Liver cancer is the third leading cause of cancer-related deaths and ranks as sixth most prevalent type globally. NAFLD or metabolic dysfunction-associated steatotic liver disease, its more severe manifestation, NASH steatohepatitis (MASH), pose a significant global health concern, affecting approximately 20%-25% population. The increased prevalence disease MASH parallel to increasing rates obesity-associated diseases, including 2 diabetes, insulin resistance, fatty diseases. can progress MASH-related HCC (MASH-HCC) in about 2% cases each year, influenced by various factors such genetic mutations, carcinogen exposure, immune microenvironment, microbiome. MASH-HCC exhibits distinct molecular characteristics compared other causes affects both men women equally. management early intermediate-stage typically involves surgery locoregional therapies, while advanced treated with systemic anti-angiogenic therapies checkpoint inhibitors. In this comprehensive review, we consolidate previous research findings also providing current insights into intricate processes underlying development. We delve MASH-HCC-associated variations somatic progression models, multiomics analysis, immunological microenvironmental impacts, discuss targeted/combined overcome evasion biomarkers recognize treatment responders. By furthering our comprehension mechanisms MASH-HCC, goal catalyze advancement potent strategies, ultimately enhanced patient outcomes.
Language: Английский
Citations
43
Metabolism, Journal Year: 2025, Volume and Issue: unknown, P. 156237 - 156237
Published: March 1, 2025
Language: Английский
Citations
2
Scientific Reports, Journal Year: 2021, Volume and Issue: 11(1)
Published: Sept. 29, 2021
Abstract Fibrosis is characterized by the excessive production of collagen and other extracellular matrix (ECM) components represents a leading cause morbidity mortality worldwide. Previous studies nonalcoholic steatohepatitis (NASH) with fibrosis were largely restricted to bulk transcriptome profiles. Thus, our understanding this disease limited an incomplete characterization liver cell types in general hepatic stellate cells (HSCs) particular, given that activated HSCs are major fibrogenic population. To help fill gap, we profiled 17,810 non-parenchymal derived from six healthy human livers. In conjunction public single-cell data fibrotic/cirrhotic livers, these profiles enable identification potential intercellular signaling axes (e.g., ITGAV–LAMC1, TNFRSF11B–VWF NOTCH2–DLL4) master regulators RUNX1 CREB3L1 ) responsible for activation during fibrogenesis. Bulk RNA-seq NASH patient livers rodent models diverse etiologies allowed us evaluate translatability candidate therapeutic targets NASH-related fibrosis. We identified 61 fibrosis-associated genes AEBP1, PRRX1 LARP6 may serve as repertoire translatable drug target candidates. Consistent above regulon results, gene regulatory network analysis regulator many genes. Together, study highlights cell–cell interactions underlie HSC reveals represent prospective hallmark signatures
Language: Английский
Citations
78
Seminars in Immunopathology, Journal Year: 2021, Volume and Issue: 43(4), P. 577 - 590
Published: July 8, 2021
Abstract Bile acids and their signaling pathways are increasingly recognized as potential therapeutic targets for cholestatic metabolic liver diseases. This review summarizes new insights in bile acid physiology, focusing on regulatory roles of the control immune regulation effects pharmacological modulators human disease. Recent mouse studies have highlighted importance interactions between gut microbiome. Interfering with microbiome composition may be beneficial diseases by modulating formation secondary acids, different species functions. receptors such FXR, VDR, TGR5 expressed a variety cells involved innate well adaptive immunity, specific microbial metabolites positively modulate responses host. Identification Cyp2c70 enzyme responsible generation hydrophilic mouse/rat-specific muricholic has allowed murine models human-like composition. These novel will aid to accelerate translational research (patho)physiological .
Language: Английский
Citations
77
Cellular and Molecular Immunology, Journal Year: 2022, Volume and Issue: 19(7), P. 834 - 847
Published: May 20, 2022
Language: Английский
Citations
67