The effect of a cognitive training therapy based on stimulation of brain oscillations in patients with mild cognitive impairment in a Chilean sample: study protocol for a phase IIb, 2 × 3 mixed factorial, double-blind randomised controlled trial DOI Creative Commons
Alejandra Figueroa-Vargas, Begoña Góngora Costa, Maria Francisca Alonso‐Sánchez

et al.

Trials, Journal Year: 2024, Volume and Issue: 25(1)

Published: Feb. 23, 2024

Abstract Background The ageing population has increased the prevalence of disabling and high-cost diseases, such as dementia mild cognitive impairment (MCI). latter can be considered a prodromal phase some dementias critical stage for interventions to postpone functionality. Working memory (WM) is pivotal function, representing fundamental element executive functions. This project proposes an intervention protocol enhance WM in these users, combining training with transcranial electrical stimulation alternating current (tACS). technique been suggested neuronal plasticity needed processes involving oscillatory patterns. stands benefit significantly from this approach, given its well-defined electrophysiological oscillations. Therefore, tACS could potentially boost patients neurodegenerative diseases. Methods study IIb randomised, double-blind clinical trial 3-month follow-up period. participants will 62 diagnosed MCI, aged over 60, Valparaíso, Chile. Participants receive twelve sessions tACS. either or placebo eight out sessions. Sessions occur twice weekly 6 weeks. primary outcomes electroencephalographic measurements through prefrontal theta activity, while secondary effects assessments WM. evaluated before, immediately after, 3 months after end intervention. Discussion add empirical evidence about benefits feasibility that combines non-invasive brain stimulation. objective contribute tools optimal treatment MCI. To capacity, functionality, obtain better quality life. Trial registration ClinicalTrials.gov NCT05291208. Registered on 28 February 2022. ISRCTN87597719 retrospectively registered 15 September 2023.

Language: Английский

Using non-invasive brain stimulation to modulate performance in visuomotor rotation adaptation: a scoping review DOI
Long Chen, Yipeng Liu, Zhongpeng Wang

et al.

Cortex, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Boosting working memory in the elderly: driving prefrontal theta–gamma coupling via repeated neuromodulation DOI Creative Commons
Lukas Diedrich,

Hannah I. Kolhoff,

Clara Bergmann

et al.

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: July 12, 2024

Abstract The escalating global burden of age-related neurodegenerative diseases and associated healthcare costs necessitates innovative interventions to stabilize or enhance cognitive functions. Deficits in working memory (WM) are linked alterations prefrontal theta–gamma cross-frequency coupling. Low-intensity transcranial alternating current stimulation (tACS) has emerged as a non-invasive, low-cost approach capable modulating ongoing oscillations targeted brain areas through entrainment. This study investigates the impact multi-session peak-coupled tACS administered dorsolateral cortex (DLPFC) on WM performance older adults. In randomized, sham-controlled, triple-blinded design, 77 participants underwent 16 sessions over six weeks while performing n -back tasks. Signal detection measures revealed increased 2-back sensitivity robust modulations response bias, indicating improved decision-making adaptations, respectively. No effects were observed 1-back condition, emphasizing dependencies load. Repeated reinforces behavioral changes, indicated by increasing effect sizes. supports prior research correlating coupling with processes provides unique insights into neurocognitive benefits repeated intervention. well-tolerated highly effective intervention among elderly underscores its therapeutic potential vulnerable populations.

Language: Английский

Citations

3
Accelerated HD-tACS for craving and cognition in synthetic cannabinoid use disorder: a case report DOI
Yan Long, Qianlan Yin, Daqing Shi

et al.

Journal of Addictive Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 6

Published: May 6, 2025

Transcranial alternating current stimulation (tACS), a noninvasive neuromodulation technique, has been demonstrated to improve cognitive function. Recent advances in protocols have introduced an accelerated intervention paradigm, which shown promising therapeutic outcomes across various brain modalities. Despite these encouraging developments enhancement, there remains significant gap the literature regarding potential applications of tACS substance use disorders. We present case 22-year-old man diagnosed with synthetic cannabinoid disorder (SCUD), who underwent high-definition (HD-tACS) over two days. Changes attention bias, craving, and impulsivity were assessed by electroencephalography (EEG), standardized scale, behavioral test. The results revealed that patient experienced reductions pathological drug impulsive risk-taking behaviors following HD-tACS intervention, craving behavior control sustained for five weeks post-treatment. This is first confirm feasibility, safety, efficacy treating SCUD, effects up weeks, highlighting need further systematic investigations

Language: Английский

Citations

0
Lesion network guided delta frequency neuromodulation improves cognition in patients with psychosis spectrum disorders: A pilot study DOI
Willa Molho, Nicolas Raymond, Robert M. G. Reinhart

et al.

Asian Journal of Psychiatry, Journal Year: 2023, Volume and Issue: 92, P. 103887 - 103887

Published: Dec. 26, 2023

Language: Английский

Citations

8
The effect of a cognitive training therapy based on stimulation of brain oscillations in patients with mild cognitive impairment in a Chilean sample: study protocol for a phase IIb, 2 × 3 mixed factorial, double-blind randomised controlled trial DOI Creative Commons
Alejandra Figueroa-Vargas, Begoña Góngora Costa, Maria Francisca Alonso‐Sánchez

et al.

Trials, Journal Year: 2024, Volume and Issue: 25(1)

Published: Feb. 23, 2024

Abstract Background The ageing population has increased the prevalence of disabling and high-cost diseases, such as dementia mild cognitive impairment (MCI). latter can be considered a prodromal phase some dementias critical stage for interventions to postpone functionality. Working memory (WM) is pivotal function, representing fundamental element executive functions. This project proposes an intervention protocol enhance WM in these users, combining training with transcranial electrical stimulation alternating current (tACS). technique been suggested neuronal plasticity needed processes involving oscillatory patterns. stands benefit significantly from this approach, given its well-defined electrophysiological oscillations. Therefore, tACS could potentially boost patients neurodegenerative diseases. Methods study IIb randomised, double-blind clinical trial 3-month follow-up period. participants will 62 diagnosed MCI, aged over 60, Valparaíso, Chile. Participants receive twelve sessions tACS. either or placebo eight out sessions. Sessions occur twice weekly 6 weeks. primary outcomes electroencephalographic measurements through prefrontal theta activity, while secondary effects assessments WM. evaluated before, immediately after, 3 months after end intervention. Discussion add empirical evidence about benefits feasibility that combines non-invasive brain stimulation. objective contribute tools optimal treatment MCI. To capacity, functionality, obtain better quality life. Trial registration ClinicalTrials.gov NCT05291208. Registered on 28 February 2022. ISRCTN87597719 retrospectively registered 15 September 2023.

Language: Английский

Citations

3