A compositionally synergistic approach for the development of a multifunctional bilayer scaffold with antibacterial property for infected and chronic wounds

Chemical Engineering Journal, Journal Year: 2021, Volume and Issue: 423, P. 130219 - 130219

Published: May 8, 2021

Language: Английский

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Current Understanding of Potential Linkages between Biocide Tolerance and Antibiotic Cross-Resistance

Microorganisms, Journal Year: 2023, Volume and Issue: 11(8), P. 2000 - 2000

Published: Aug. 3, 2023

Antimicrobials (e.g., antibiotics and biocides) are invaluable chemicals used to control microbes in numerous contexts. Because of the simultaneous use biocides, questions have arisen as whether environments commonly treated with biocides hospitals, food processing, wastewater, agriculture, etc.) could act a reservoir for development antibiotic cross-resistance. Theoretically, cross-resistance occur if mechanism bacterial tolerance also resulted resistance. On other hand, would likely present higher evolutionary barrier resistance given different modes action between broad-based physicochemical effects associated most biocides. Published studies shown that induction biocide laboratory can result some antibiotics, hypothesized be due efflux pump upregulation. However, testing environmental isolates has yielded conflicting results, potentially lack standardized testing. In this review, we aim describe state science on potential linkage Questions still remain about directed evolution or not representative real-world settings. Thus, research should continue generate informative data guide policies preserve these tools’ utility availability.

Language: Английский

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Bacterial sensitivity to chlorhexidine and povidone-iodine antiseptics over time: a systematic review and meta-analysis of human-derived data

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Jan. 7, 2023

Surgical site infection (SSI) is the most common complication of surgery, increasing healthcare costs and hospital stay. Chlorhexidine (CHX) povidone-iodine (PVI) are used for skin antisepsis, minimising SSIs. There concern that resistance to topical biocides may be emergeing, although potential clinical implications remain unclear. The objective this systematic review was determine whether minimum bactericidal concentration (MBC) preparations CHX or PVI have changed over time, in microbes relevant SSI. We included studies reporting MBC laboratory isolates PVI. excluded using non-human samples antimicrobial solvents mixtures with other active substances. pooled random effects meta-analyses change time explored meta-regression. Seventy-nine were included, analysing 6218 45 years. Most investigated (93%), insufficient data meta-analysis no Staphylococci Streptococci time. Overall, we find evidence reduced susceptibility SSI-causing This provides reassurance confidence worldwide guidance should first-choice agent surgical antisepsis.

Language: Английский

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Nasal Iodophor Antiseptic vs Nasal Mupirocin Antibiotic in the Setting of Chlorhexidine Bathing to Prevent Infections in Adult ICUs

JAMA, Journal Year: 2023, Volume and Issue: 330(14), P. 1337 - 1337

Published: Oct. 10, 2023

Importance Universal nasal mupirocin plus chlorhexidine gluconate (CHG) bathing in intensive care units (ICUs) prevents methicillin-resistant S taphylococcus aureus (MRSA) infections and all-cause bloodstream infections. Antibiotic resistance to has raised questions about whether an antiseptic could be advantageous for ICU decolonization. Objective To compare the effectiveness of iodophor vs universal decolonization combination with CHG bathing. Design, Setting, Participants Two-group noninferiority, pragmatic, cluster-randomized trial conducted US community hospitals, all which used mupirocin-CHG ICUs at baseline. Adult patients 137 randomized hospitals during baseline (May 1, 2015-April 30, 2017) intervention (November 2017-April 2019) were included. Intervention involving switching iodophor-CHG (intervention) or continuing (baseline). Main Outcomes Measures ICU-attributable clinical cultures (primary outcome), MRSA cultures, evaluated using proportional hazard models assess differences from periods between strategies. Results also compared a 2009-2011 no same hospital network. The prespecified noninferiority margin primary outcome was 10%. Among 801 668 admissions 233 ICUs, participants’ mean (SD) age 63.4 (17.2) years, 46.3% female, length stay 4.8 (4.7) days. Hazard ratios (HRs) isolates 1.17 (raw rate: 5.0 4.3/1000 days) 0.99 4.1 4.0/1000 (HR difference significantly lower by 18.4% [95% CI, 10.7%-26.6%] mupirocin-CHG, P < .001). For HRs 1.13 2.3 2.1/1000 2.0 2.0/1000 14.1% 3.7%-25.5%] = .007). all-pathogen infections, 1.00 (2.7 2.7/1000) 1.01 (2.6 2.6/1000) (nonsignificant HR differences, −0.9% −9.0% 8.0%]; .84). Compared trial, 30-day relative reduction hazards group (2009-2011 trial) as follows: (current trial: 48.1% 35.6%-60.1%]; 58.8% 47.5%-70.7%]) infection rates 70.4% 62.9%-77.8%]; 60.1% 49.1%-70.7%]). Conclusions Relevance Nasal did not meet criteria considered noninferior antibiotic adult context daily In addition, results consistent being inferior mupirocin. Trial Registration ClinicalTrials.gov Identifier: NCT03140423

Language: Английский

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Controllable Release of Povidone-Iodine from Networked Pectin@Carboxymethyl Pullulan Hydrogel

Polymers, Journal Year: 2021, Volume and Issue: 13(18), P. 3118 - 3118

Published: Sept. 15, 2021

Povidone-iodine (PI) is a common antiseptic reagent which used for skin infections and wound healing. The control release of PI quite important to heal the deep intense wounds. Herein, preparation biodegradable pectin@carboxymethyl pullulan (Pe@CMP) hydrogel was carried out applied controllable PI. CMP synthesized by interaction monochloroacetic acid with at different ratios. Pe@CMP then prepared crosslinking pectin in presence glutaraldehyde as cross linker. After carboxymethylation, COOH contents were enlarged be 24.2-51.2 mmol/kg degree substitution 0.44-0.93. rheological properties increment ratio. Swelling ratio water (16.0-18.0%) higher than that artificial sweat (11.7-13.2%). containing 20% pectin, exhibited lowest 57.7% from released within 360 min. biological activity monitored highly efficient. kinetic fitted well first ordered reaction Higuchi models. mechanism explained swelling hydrogel. networked structure opened outer pores followed inner pores, achieving release.

Language: Английский

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Review of the Use of Nasal and Oral Antiseptics During a Global Pandemic

Future Microbiology, Journal Year: 2021, Volume and Issue: 16(2), P. 119 - 130

Published: Jan. 1, 2021

A review of nasal sprays and gargles with antiviral properties suggests that a number commonly used antiseptics including povidone-iodine, Listerine®, iota-carrageenan chlorhexidine should be studied in clinical trials to mitigate both the progression transmission SARS-CoV-2. Several these have demonstrated ability cut viral load SARS-CoV-2 by 3–4 log10 15–30 s vitro. In addition, hypertonic saline targets replication increasing hypochlorous acid inside cell. are process study interventions for prevention transmission, prophylaxis after exposure, diminish reduction early stages infection.

Language: Английский

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Antimicrobial stewardship of antiseptics that are pertinent to wounds: the need for a united approach

JAC-Antimicrobial Resistance, Journal Year: 2021, Volume and Issue: 3(1)

Published: Jan. 18, 2021

Long before the nature of infection was recognized, or significance biofilms in delayed healing understood, antimicrobial agents were being used wound care. In last 70 years, antibiotics have provided an effective means to control infection, but continued emergence antibiotic-resistant strains and documented antibiotic tolerance has reduced their effectiveness. A range dressings containing (antibiotic non-antibiotic compound) been developed. Whereas standardized methods for determining efficacy antimicrobials bacterial suspension tests developed early twentieth century, ways evaluating against microbial suspensions are not available. Resistance cross-resistance with reported, consensus on breakpoints is absent surveillance impossible. Antimicrobial stewardship therefore jeopardy. This review highlights these difficulties particular current dressings, efficacy, challenges translating

Language: Английский

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Evaluation of the role of povidone‑iodine in the prevention of surgical site infections

Surgery Open Science, Journal Year: 2023, Volume and Issue: 13, P. 9 - 17

Published: March 16, 2023

The occurrence of surgical site infections (SSIs) is associated with increased risk mortality, development other infections, and the need for reintervention, posing a significant health burden. aim this review was to examine current data guidelines around use antiseptic povidone‑iodine (PVP-I) prevention SSIs at each stage intervention.

Language: Английский

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An objective comparative study of non‐surgical cleansing techniques and cleanser types in bacterial burden management

International Wound Journal, Journal Year: 2024, Volume and Issue: 21(2)

Published: Feb. 1, 2024

Abstract Cleansing is a vital component of effective wound hygiene and biofilm management, often accomplished through vigorous mechanical action or soaking with moistened gauze. In the present study, quantitative comparison effectiveness different cleansing techniques solutions in removing bacteria was conducted on 71 chronic wounds using bacterial fluorescence imaging as real‐time diagnostic for moderate to high loads. Vigorous gauze 30 s proved most by reducing 33.99%, surpassing 10‐min reduction (13.24%). Among cleansers, no statistically significant differences were observed, but povidone‐iodine showed strongest trend towards reduction. Sub‐analysis highlighted superiority antiseptic cleansers over saline gentle soap (−33.30% vs. −1.80% respectively). Five percent acetic acid also shown be more specific strains ( Pseudomonas aeruginosa ). Findings from studies like this contribute refining guidelines clinical algorithms management.

Language: Английский

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Staphylococcus aureus screening and preoperative decolonisation with Mupirocin and Chlorhexidine to reduce the risk of surgical site infections in orthopaedic surgery: a pre-post study

Antimicrobial Resistance and Infection Control, Journal Year: 2024, Volume and Issue: 13(1)

Published: July 11, 2024

Abstract Background Nasal carriage of Staphylococcus aureus is a risk factor for surgical site infections (SSI) in orthopaedic surgery. The efficacy decolonisation S. on reducing the SSI uncertain this speciality. objective was to evaluate impact nasal screening strategy and targeted SSI. Methods A retrospective pre-post here-elsewhere study conducted between January 2014 June 2020 2 adult sites (North South) French university hospital. Decolonisation with Mupirocin Chlorhexidine carriers starting February 2017 South (intervention group). Scheduled procedures hip, knee arthroplasties, osteosyntheses were included monitored one year. rates intervention group compared historical control (South site) North group. factors analysed by logistic regression. Results total 5,348 included, 100 which 30 monomicrobial identified. preoperative result available 60% (1,382/2,305) patients. Among these screenings, 25.3% (349/1,382) positive 91.6% (98/107). rate (0.3%, 7/2,305) not significantly different from (0.5%, 9/1926) but differed (1.3%, 14/1,117). After adjustment, occurrence body mass index (ORa per unit , 1.05; 95%CI, 1.0-1.1), Charlson comorbidity point 1.34; 1.0–1.8) operative time minute 1.01; 1.00–1.02). Having benefited screening/decolonisation protective (ORa, 0.24; 0.08–0.73). Conclusions Despite low number SSI, associated reduction

Language: Английский

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