Animal Feed Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 116186 - 116186
Published: Dec. 1, 2024
Language: Английский
Gut, Journal Year: 2024, Volume and Issue: 73(11), P. 1893 - 1908
Published: Sept. 25, 2024
The understanding that changes in microbiome composition can influence chronic human diseases and the efficiency of therapies has driven efforts to develop microbiota-centred such as first next generation probiotics, prebiotics postbiotics, microbiota editing faecal transplantation. Central research is how disease impacts vice versa, yet there a problematic issue with term 'dysbiosis', which broadly links microbial imbalances various illnesses without precision or definition. Another significant discussions defining 'healthy individuals' ascertain what characterises healthy microbiome. This involves questioning who represents healthiest segment our population-whether it those free from illnesses, athletes at peak performance, individuals living healthily through regular exercise good nutrition even elderly adults centenarians have been tested by time achieved remarkable longevity.This review advocates for delineating 'what defines microbiome?' considering broader range factors related health environmental influences on microbiota. A undoubtedly linked gut health. Nevertheless, very difficult pinpoint universally accepted definition 'gut health' due complexities measuring functionality besides composition. We must take into account individual variabilities, diet, lifestyle, host factors. Moreover, challenge distinguishing causation correlation between overall presented.The also highlights resource-heavy nature comprehensive assessments, hinders their practicality broad application. Finally, we call continued nuanced approach better understand intricate evolving concept health, emphasising need more precise inclusive definitions methodologies studying
Language: Английский
Citations
43
Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)
Published: Feb. 16, 2025
The gut microbiota-derived metabolite indole-3-propionic acid (IPA) plays an important role in maintaining intestinal mucosal homeostasis, while the molecular mechanisms underlying IPA regulation on CD4+ T cell functions inflammatory bowel disease (IBD) remain elusive. Here we investigated roles of modulating cells and its therapeutic potential treatment human IBD. Leveraging metabolomics microbial community analyses, observed that levels IPA-producing microbiota (e.g. Peptostreptococcus, Clostridium, Fournierella) were decreased, IPA-consuming Parabacteroides, Erysipelatoclostridium, Lachnoclostridium) increased feces IBD patients than those healthy donors. Dextran sulfate sodium (DSS)-induced acute colitis CD45RBhighCD4+ transfer-induced chronic models then established mice treated orally with to study inflammation vivo. We found oral administration attenuated both mice, as characterized by body weight, reduced pro-inflammatory cytokines TNF-α, IFN-γ, IL-17A) histological scores colon. further utilized RNA sequencing, docking simulations, surface plasmon resonance analyses identified exerts biological effects interacting heat shock protein 70 (HSP70), leading inducing Th1/Th17 apoptosis. Consistently, ectopic expression HSP70 conferred resistance IPA-induced Therefore, these findings identify a previously unrecognized pathway which modulates provide promising avenue for
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12321 - 12321
Published: Nov. 16, 2024
Obesity, a global public health problem, is constantly increasing, so the concerns in preventing and combating it are increasingly focused on intestinal microbiota. It was found that microbiota different lean people compared to obese individuals, but exact mechanisms by which energy homeostasis influenced still incompletely known. Numerous studies show involvement of certain bacterial species promoting obesity associated diseases such as diabetes, hypertension, cancer, etc. Our aim summarize main findings regarding influence several factors lifestyle changes, including diet bariatric surgery, diversity gut individuals. The second purpose this paper investigate potential effect various modulation techniques ameliorating its comorbidities. A literature search conducted using PubMed database, identifying articles published between 2019 2024. Most identified suggest generally with alterations microbiome decreased microbial diversity, an increased Firmicutes-to-Bacteroidetes ratio, SCFAs levels. also indicate could represent novel strategy treating related metabolic diseases. Although some (e.g., inflammation or hormonal regulation) already considered powerful connection development, further research needed enhance knowledge particular topic.
Language: Английский
Citations
5
Gut, Journal Year: 2025, Volume and Issue: unknown, P. gutjnl - 333855
Published: Feb. 11, 2025
Language: Английский
Citations
0
Computational and Structural Biotechnology Journal, Journal Year: 2025, Volume and Issue: 27, P. 879 - 886
Published: Jan. 1, 2025
Language: Английский
Citations
0
Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101685 - 101685
Published: March 19, 2025
Language: Английский
Citations
0
Food and Agricultural Immunology, Journal Year: 2025, Volume and Issue: 36(1)
Published: April 20, 2025
Language: Английский
Citations
0
Future Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 11(1)
Published: April 24, 2025
Abstract Background Malnutrition is still one of the most serious and prevalent worldwide health problems, especially found in low- middle-income countries, which impairs immune functions increases susceptibility to infection. This study investigates complex association between malnutrition dysfunction, role immunomodulators restoring function. analyzes different types malnutrition, including protein-energy micronutrient deficiencies, their consequences system through inhibited cytokine cell production. Main body Immunomodulators, include natural agents such as phytochemicals probiotics, well synthetic agents, may help reduce dysfunction related starvation. article categorizes these discusses mechanisms action, regulating inflammatory pathways, increasing generation cells, augmenting global response. In addition, therapeutic approaches utilizing immunomodulation conjunction with nutritional therapies, supplementation (vitamins A, C, D zinc) or immunomodulators, improve gastroenterological disease states are discussed. Case reports recent studies provided that provide evidence supporting effectiveness therapy clinical outcomes vulnerable populations. Conclusion While there a promise for safety, long-term efficacy, ethical issues address before they could widely be employed. Each step research calls applied, working example immunomodulatory medicine tailored programs internationally. The highlights vital treatment encourages holistic immunological worldwide.
Language: Английский
Citations
0
Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12
Published: May 1, 2025
Background Frailty severely impacts patients’ quality of life and imposes a significant burden on healthcare systems. The Dietary Index for Gut Microbiota (DI-GM) is an emerging dietary indicator, its association with frailty has not been thoroughly investigated. Methods This study utilized data from NHANES 2007–2018 assessed the between DI-GM using multivariable weighted logistic regression, restricted cubic splines (RCS), subgroup analysis, mediation after adjusting relevant covariates. Results results indicate negative correlation frailty, each standard unit increase in reducing risk by 6% (OR = 0.940 [0.899, 0.984]). at different quartiles showed strong dose–response relationship, highest quartile showing 21.6% reduction. RCS analysis revealed linear relationship frailty. Subgroup suggested that age smoking status may influence Furthermore, albumin high-density lipoprotein (HDL) played mediating roles accounting 30.34 9.05% total effect, respectively. Conclusion negatively associated risk, HDL mediate this association. Improving be effective strategy risk.
Language: Английский
Citations
0
Molecular Nutrition & Food Research, Journal Year: 2024, Volume and Issue: 68(22)
Published: Nov. 1, 2024
Scope Adipose tissue macrophages (ATMs) are crucial in the pathogenesis of insulin resistance (IR). Intermittent fasting (IF) is an effective intervention for obesity. However, underlying mechanism by which IF improves IR remains unclear. Methods and results Male C57BL/6J mice fed chow‐diet high‐fat diet (HFD) 12 weeks, then randomized into ad libitum feeding or every other day 8 weeks. Markers ATMs expression uncoupling protein 1 (UCP‐1) determined. Gut microbiota bile acids (BAs) profiled using 16S rRNA sequencing targeted metabolomics analysis. Results indicate that HFD‐induced decreases ATM infiltration, pro‐inflammatory M1 gene expression, promotes white adipose (WAT) browning elevating UCP‐1 expression. restructures composition, significantly expanding abundance Verrucomicrobia particularly Akkermansia muciniphila , with decrease Firmicutes . increases level total BAs alters composition higher proportion 12α‐hydroxylated (12α‐OH) BAs. The changes these correlated differential bacteria. Conclusion findings partially mediated interplay between restructured gut metabolism, has implications dietary management
Language: Английский
Citations
2