Translating phage therapy into the clinic: Recent accomplishments but continuing challenges

PLoS Biology, Journal Year: 2023, Volume and Issue: 21(5), P. e3002119 - e3002119

Published: May 23, 2023

Phage therapy is a medical form of biological control bacterial infections, one that uses naturally occurring viruses, called bacteriophages or phages, as antibacterial agents. Pioneered over 100 years ago, phage nonetheless currently experiencing resurgence in interest, with growing numbers clinical case studies being published. This renewed enthusiasm due large part to holding promise for providing safe and effective cures infections traditional antibiotics acting alone have been unable clear. Essay introduces basic biology, provides an outline the long history therapy, highlights some advantages using phages agents, overview recent successes. Although has clear potential, it faces biological, regulatory, economic challenges its further implementation more mainstream acceptance.

Language: Английский

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Phage Therapy—Challenges, Opportunities and Future Prospects

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(12), P. 1638 - 1638

Published: Nov. 22, 2023

The increasing drug resistance of bacteria to commonly used antibiotics creates the need search for and develop alternative forms treatment. Phage therapy fits this trend perfectly. Phages that selectively infect kill are often only life-saving therapeutic option. Full legalization treatment method could help solve problem multidrug-resistant infectious diseases on a global scale. aim review is present prospects development phage therapy, ethical legal aspects form given current situation such benefits using products in persons whom available options have been exhausted or do not exist at all. In addition, challenges faced by fight against bacterial infections also described. More clinical studies needed expand knowledge about phages, their dosage, standardized delivery system. These activities necessary ensure phage-based does take an experiment but standard medical Bacterial viruses will probably become miracle cure—a panacea infections—but they chance find important place medicine.

Language: Английский

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Bacteriophage targeting microbiota alleviates non-alcoholic fatty liver disease induced by high alcohol-producing Klebsiella pneumoniae

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: June 3, 2023

Our previous studies have shown that high alcohol-producing Klebsiella pneumoniae (HiAlc Kpn) in the intestinal microbiome could be one of causes non-alcoholic fatty liver disease (NAFLD). Considering antimicrobial resistance K. and dysbacteriosis caused by antibiotics, phage therapy might potential treatment HiAlc Kpn-induced NAFLD, because specificity targeting bacteria. Here, we clarified effectiveness male mice with steatohepatitis. Comprehensive investigations including transcriptomes metabolomes revealed Kpn-specific was able to alleviate steatohepatitis Kpn, hepatic dysfunction expression cytokines lipogenic genes. In contrast, such did not cause significantly pathological changes, either functions kidney, or components gut microbiota. addition reducing alcohol attack, also regulated inflammation, lipid carbohydrate metabolism. data suggest microbiota is an alternative efficacy safety, at least Kpn-caused NAFLD.

Language: Английский

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Pharmacokinetics/pharmacodynamics of phage therapy: a major hurdle to clinical translation

Clinical Microbiology and Infection, Journal Year: 2023, Volume and Issue: 29(6), P. 702 - 709

Published: Feb. 2, 2023

Language: Английский

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Bacterial therapies at the interface of synthetic biology and nanomedicine

Nature Reviews Bioengineering, Journal Year: 2023, Volume and Issue: 2(2), P. 120 - 135

Published: Oct. 10, 2023

Language: Английский

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