Phage Therapy—Challenges, Opportunities and Future Prospects

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(12), P. 1638 - 1638

Published: Nov. 22, 2023

The increasing drug resistance of bacteria to commonly used antibiotics creates the need search for and develop alternative forms treatment. Phage therapy fits this trend perfectly. Phages that selectively infect kill are often only life-saving therapeutic option. Full legalization treatment method could help solve problem multidrug-resistant infectious diseases on a global scale. aim review is present prospects development phage therapy, ethical legal aspects form given current situation such benefits using products in persons whom available options have been exhausted or do not exist at all. In addition, challenges faced by fight against bacterial infections also described. More clinical studies needed expand knowledge about phages, their dosage, standardized delivery system. These activities necessary ensure phage-based does take an experiment but standard medical Bacterial viruses will probably become miracle cure—a panacea infections—but they chance find important place medicine.

Language: Английский

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Phage-specific immunity impairs efficacy of bacteriophage targeting Vancomycin Resistant Enterococcus in a murine model

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: April 6, 2024

Abstract Bacteriophage therapy is a promising approach to address antimicrobial infections though questions remain regarding the impact of immune response on clinical effectiveness. Here, we develop mouse model assess phage treatment using cocktail five phages from Myoviridae and Siphoviridae families that target Vancomycin-Resistant Enterococcus gut colonization. Phage significantly reduces fecal bacterial loads Enterococcus. We also characterize responses elicited following administration cocktail. While minimal innate are observed after administration, two rounds induces phage-specific neutralizing antibodies accelerate clearance tissues. Interestingly, myophages in our induce more robust antibody than siphophages. This anti-phage immunity effectiveness murine model. Collectively, this study shows may be an important consideration development cocktails for therapeutic use.

Language: Английский

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Current Knowledge and Perspectives of Phage Therapy for Combating Refractory Wound Infections

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5465 - 5465

Published: May 17, 2024

Wound infection is one of the most important factors affecting wound healing, so its effective control critical to promote process healing. However, with increasing prevalence multi-drug-resistant (MDR) bacterial strains, prevention and treatment infections are now more challenging, imposing heavy medical financial burdens on patients. Furthermore, diminishing effectiveness conventional antimicrobials declining research new antibiotics necessitate urgent exploration alternative treatments for infections. Recently, phage therapy has been revitalized as a promising strategy address challenges posed by in era antibiotic resistance. The use treating infectious diseases demonstrated positive results. This review provides an overview mechanisms, characteristics, delivery methods combating pathogenic bacteria. Then, we focus clinical application various therapies managing refractory infections, such diabetic foot well traumatic, surgical, burn Additionally, analysis potential obstacles practice presented, along corresponding strategies addressing these issues. serves enhance our understanding innovative avenues

Language: Английский

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Bacteriophages: A Challenge for Antimicrobial Therapy

Microorganisms, Journal Year: 2025, Volume and Issue: 13(1), P. 100 - 100

Published: Jan. 7, 2025

Phage therapy, which involves the use of bacteriophages (phages) to combat bacterial infections, is emerging as a promising approach address escalating threat posed by multidrug-resistant (MDR) bacteria. This brief review examines historical background and recent advancements in phage research, focusing on their genomics, interactions with host bacteria, progress medical biotechnological applications. Additionally, we expose key aspects mechanisms action, therapeutic uses considerations treating MDR infections are discussed, particularly context related virus-bacteria interactions.

Language: Английский

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Revisiting therapeutic options against Resistant Klebsiella Pneumoniae infection: phage therapy is key

Microbiological Research, Journal Year: 2025, Volume and Issue: unknown, P. 128083 - 128083

Published: Jan. 1, 2025

Language: Английский

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Oral bacteriophages and their potential as adjunctive treatments for periodontitis: a narrative review

Journal of Oral Microbiology, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 25, 2025

Background There is no specific cure for periodontitis and treatment symptomatic, primarily by physical removal of the subgingival plaque biofilm. Current non-surgical periodontal therapy becomes less effective as pocket depth increases such new adjunctive treatments are required. The development antibiotic resistance has driven a recent resurgence interest in bacteriophage therapy.

Language: Английский

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Bacteriophage therapy for multidrug-resistant infections: current technologies and therapeutic approaches

Journal of Clinical Investigation, Journal Year: 2025, Volume and Issue: 135(5)

Published: March 2, 2025

Bacteriophage (phage) therapy has emerged as a promising solution to combat the growing crisis of multidrug-resistant (MDR) infections. There are several international centers actively engaged in implementation phage therapy, and recent case series have reported encouraging success rates patients receiving personalized, compassionate for difficult-to-treat Nonetheless, substantial hurdles remain way more widespread adoption consistent success. This Review offers comprehensive overview current technologies therapeutic approaches. We first delineate common steps development, from bank establishment clinical administration, examine spectrum approaches, personalized fixed cocktails. Using framework conventional drug development pipeline, we then identify critical knowledge gaps areas such cocktail design, formulation, pharmacology, trial design. conclude that, while holds promise, structured pipeline sustained government support crucial MDR

Language: Английский

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Hydrogels for Local and Sustained Delivery of Bacteriophages to Treat Wound Infections

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 10, 2024

Lytic bacteriophages, viruses that lyse (kill) bacteria, hold great promise for treating infections, including wound infections caused by antimicrobial-resistant

Language: Английский

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Therapeutic Phage Monitoring: A Review

Clinical Infectious Diseases, Journal Year: 2023, Volume and Issue: 77(Supplement_5), P. S384 - S394

Published: Nov. 1, 2023

Abstract With the global rise in antimicrobial resistance, there has been a renewed interest application of therapeutic phages to treat bacterial infections. Therapeutic phage monitoring (TPM) is proposed as an essential element therapy (PT) protocols generate data and fill knowledge gaps regarding vivo efficacy phages, patients’ immune responses PT, wider ecological effects PT. By concentrations blood tissues, together with possible changes during TPM may enable optimization dosing implementation precision medicine approaches. Furthermore, can validate diagnostic surrogates efficacy, direct research efforts, establish quality assurance indicators for products. Thus, holds great potential enhancing our understanding multidirectional phage–bacteria–host interactions advancing “best practice” ultimately improving patient care.

Language: Английский

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Phage therapy: a revolutionary shift in the management of bacterial infections, pioneering new horizons in clinical practice, and reimagining the arsenal against microbial pathogens

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10

Published: Oct. 19, 2023

The recent approval of experimental phage therapies by the FDA and other regulatory bodies with expanded access in cases United States nations caught attention media general public, generating enthusiasm for therapy. It started to alter situation so that more medical professionals are willing use conventional antibiotics. However, study is required fully comprehend therapy’s potential advantages restrictions, which still a relatively new field medicine. shows promise, nevertheless, as secure prosperous substitute antibiotics when treating bacterial illnesses animals humans. Because their uniqueness, disinfection excellent ready-to-eat (RTE) foods like milk, vegetables, meat products. traditional farm-to-fork method can be used throughout food chain employ bacteriophages prevent infections at all production stages. Phage therapy improves clinical outcomes animal models lowers burdens numerous preclinical investigations. resistance need make sure enough phages delivered infection site obstacles employing vivo . according studies, appear promising alternative compassion (a profound understanding empathy another’s suffering) has recently grown many case reports supposedly treated patients trials. This review summarizes knowledge on uses various fields, such industry, research, settings. also includes list FDA-approved bacteriophage-based products, commercial global companies therapeutic purposes.

Language: Английский

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