Clinical-epizootological features of associated bordetheliosis of cats in conditions of walking in Apostolovo, Dnipropetrovsk region DOI Open Access

Yu. V. Glushchenko,

Р. В. Северин, A. M. Gontar

et al.

VETERINARY SCIENCE TECHNOLOGIES OF ANIMAL HUSBANDRY AND NATURE MANAGEMENT, Journal Year: 2024, Volume and Issue: 9, P. 96 - 103

Published: May 23, 2024

The article presents the results of a thorough study clinical and epizootological features bordeteliosis in cats with walking habit analyzed related to identification potential reservoirs causative agent infection. Research analysis obtained data was carried out on basis private veterinary clinics city Apostolovo, Dnipropetrovsk region, period 2022-2024. Patients signs respiratory pathology. In specified period, total 87 sick tract damage were examined. To confirm laboratory diagnosis bordetelliosis, main methods detecting pathogen bacteriological method polymerase chain reaction (PCR). Samples for by taking an oropharyngeal swab, some cases, transnasal washes infectious viral diseases cats, rapid IFA tests (FHV Ag) produced ASAN PHARM (China) ZRbio used. It established that bordetellius infection registered among other pathologies at level 28,5%. As monoinfection, bordetelliosis confirmed 16,5%. found be associated rhinotracheitis calicivirus (22,5% 19,5%, respectively), panleukopenia – 9,5% chlamydia 7,5%. seasonal peak observed spring autumn months. maximum morbidity age 5 weeks 1 year 71,4%. incidence bordetella recorded animals available free range determined 65,4%. Bordeteliosis manifested itself as manifest acute subacute courses, which mucous discharge from eyes nose, increase submandibular lymph nodes, sneezing, coughing.

Language: Английский

Effects of bacteriophages on gut microbiome functionality DOI Creative Commons
Elena Kurilovich, Naama Geva‐Zatorsky

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: March 31, 2025

The gut microbiome, composed of bacteria, fungi, and viruses, plays a crucial role in maintaining the delicate balance human health. Emerging evidence suggests that microbiome disruptions can have far-reaching implications, ranging from development inflammatory diseases cancer to metabolic disorders. Bacteriophages, or "phages", are viruses specifically infect bacterial cells, their interactions with receiving increased attention. Despite recently revived interest phageome, it is still considered "dark matter" gut, more than 80% viral genomes remaining uncharacterized. Today, research focused on understanding mechanisms by which phages influence microbiota potential applications. Bacteriophages may regulate relative abundance communities, affect functions various ways, modulate mammalian host immunity. This review explores how functionality, particularly commensals pathogens, emphasizing health disease.

Language: Английский

Citations

1
Identification of the broad-spectrum lytic Bordetella phage and assessments of its potential for combating Bordetella infections DOI
Xi Huang,

Yanyan Hou,

Mengfei Zhao

et al.

Virology, Journal Year: 2025, Volume and Issue: 608, P. 110545 - 110545

Published: April 24, 2025

Language: Английский

Citations

1
Detection of Bordetella spp. in children with pertussis-like illness from 2018 to 2024 in China DOI Creative Commons

Yahong Hu,

Wei Shi,

Qinghong Meng

et al.

Journal of Infection, Journal Year: 2024, Volume and Issue: 89(3), P. 106222 - 106222

Published: July 11, 2024

To evaluate the role of Bordetella pertussis (B. pertussis), B. parapertussis, holmesii, and bronchiseptica on resurgence in China, particularly sharp rise since latest winter.

Language: Английский

Citations

5
Respiratory pathogenic microbial infections: a narrative review DOI Creative Commons

Yiyin Long,

Yan Zheng, Changlin Li

et al.

International Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: 21(5), P. 826 - 836

Published: Jan. 1, 2024

Respiratory infectious diseases have long been recognised as a substantial global healthcare burden and are one of the leading causes death worldwide, particularly in vulnerable individuals. In post COVID-19 era, there has surge prevalence influenza virus A other multiple known viruses causing cold compared with during same period previous three years, which coincided countries easing restrictions worldwide. This article aims to review community-acquired respiratory illnesses covering broad spectrum viruses, bacteria, atypical microorganisms focuses on cluster pathogens China, thereby providing effective prevention control measures.

Language: Английский

Citations

5
The virulence regulatorbvgSis required for nutrient-induced filamentation inBordetella avium DOI Creative Commons
Niklas G Perslow, Robert J. Luallen

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Bacteria can change morphology in response to stressors and changes their environment, including infection of a host. We previously identified the bacterial species, Bordetella atropi , which uses nutrient-induced filamentation as novel mechanism for cell-to-cell spreading intestinal epithelial cells nematode To further investigate conservation Bordetellae, we utilized turkey-infecting species avium filaments vitro when switched from standard growth media an enriched media. conducted selection-based screen with B. isolated two independent non-filamentous mutants that failed filament highly These contained different alleles bvgS sensor two-component master virulence regulator (BvgAS) conserved across genus. role filamentation, transcriptomics found mutation resulted loss responsiveness highly-enriched media, especially genes related nutrient uptake metabolism. The most dysregulated gene mutant encoded succinyl-CoA:acetate CoA-transferase (SCACT) were able regulate exogenous metabolites up downstream this enzyme. data suggest regulates by controlling metabolic capacity. Overall, is required suggesting there may be Bordetellae utilizing morphological phenotype.

Language: Английский

Citations

0
Pertussis in Early Infancy: Diagnostic Challenges, Disease Burden, and Public Health Implications Amidst the 2024 Resurgence, with Emphasis on Maternal Vaccination Strategies DOI Creative Commons
Konstantina Leontari, Alexandra Lianou, Andreas G. Tsantes

et al.

Vaccines, Journal Year: 2025, Volume and Issue: 13(3), P. 276 - 276

Published: March 5, 2025

Bordetella pertussis is the causative agent of or whooping cough, an acute and highly contagious respiratory infection that can have serious fatal complications such as pneumonia, encephalopathy, seizures, especially for newborns. The disease endemic not only in European Union (EU)/European Economic Area (EEA) but also globally. Larger outbreaks are anticipated every three to five years, even countries where vaccination rates high. Despite high coverage developed a low rate incidence many during COVID-19 pandemic, has been on rise again, with some places, which referred "re-emergence pertussis". aim this review underscore critical importance achieving coverage, particularly among pregnant women, safeguard vulnerable neonates from their early months, before they eligible vaccination. This aligns need address diagnostic challenges, mitigate severity, strengthen public health strategies light ongoing 2024 resurgence.

Language: Английский

Citations

0
Exploration of biomarkers for predicting the prognosis of patients with diffuse large B-cell lymphoma by machine-learning analysis DOI
Shifen Wang, Tao Hong,

Xingyun Zhao

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract Background: Diffuse large B cell lymphoma (DLBCL), one distinct origin of hematological malignancies, has caused a major public health problem. However, the molecular mechanisms was not been clearly elucidated. The aim is to explore disease-specific diagnostic biomarkers and improve this situation. Methods: Three microarray datasets (GSE25638, GSE12195, GSE12453) were downloaded from Gene Expression Omnibus (GEO) database. key genes in DLBCL patients screened by differential expression (DEGs) analysis weighted gene co-expression network (WGCNA). Functional enrichment protein-protein interaction (PPI) construction employed reveal DLBCL-related pathogenic molecules underlying mechanisms. Random forest adopted for screening candidate biomarkers, Kaplan Meier survival constructed predict risk patients. single‐sample set used immune infiltration lymphoma. Validation hub confirmed RT-PCR immunohistochemistry (IHC) tests. Results: 95 obtained three about DEGs WGCNA. four (CXCL9, CCL18, C1QA, CTSC) random machine learning algorithm. ROC results showed that AUC 1.00 training set, bootstrap verification performed 1000 times external validation size 0.839. several pathways found Kyoto Encyclopedia Genes Genomes (KEGG) Ontology (GO) analysis. identified be excellent potential Dysregulated infiltrations observed DLBCL, as well positive correlations with genes, respectively. high expressions also demonstrated Conclusion: This study could CXCL9 may essential developing disease, which provided new perspective mechanism therapeutic targets DLBCL.

Language: Английский

Citations

0
MASP1 modulation as a novel therapeutic target in severe pediatric pertussis: insights from a multi-omics approach DOI Creative Commons

Lin Xu,

Caiying Wang, Yuhuan Liu

et al.

Infection and Immunity, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

ABSTRACT Pertussis, a severe infectious disease in children, has become increasingly prominent recent years. This study aims to investigate the role of MASP1 protein pertussis children through multi-omics analysis, providing theoretical basis for development novel therapeutic strategies. The retrieved macro-genome and 16S rRNA data pediatric from public databases analyze microbial diversity specific flora abundance, conducting pathway functional enrichment analysis. Differential expression analysis transcriptome Gene Ontology (GO)/Kyoto Encyclopedia Genes Genomes (KEGG) combined with machine learning, identified key gene MASP1. A Bordetella infection model was established using human bronchial epithelial cell line HBE135-E6E7 validate changes its relationship airway damage by constructing lines overexpressing knocking down Finally, impact inhibiting on symptoms evaluated mouse model. results revealed significant differences abundance between healthy those pertussis, significantly upregulated inhibition alleviating symptoms. highlights critical crucial foundation developing strategies targeting

Language: Английский

Citations

0
Monitoring of Pathogens Carried by Imported Flies and Cockroaches at Shenzhen Ports DOI Creative Commons

Siqi Zhang,

Chunzhong Zhao,

Guoping Liu

et al.

Tropical Medicine and Infectious Disease, Journal Year: 2025, Volume and Issue: 10(2), P. 57 - 57

Published: Feb. 17, 2025

This study tested the efficacy of xenomonitoring using contaminated flies and cockroaches at ports in Shenzhen by analysing sample data from imported October 2023 to April 2024 identify pathogens they carried. Among all samples collected, Musca domestica vicina Blattella germanica accounted for highest proportion, 27.59% 66.47%, respectively. Their positive rates carrying Staphylococcus aureus were also most significant, reaching 4.35% 6.47%, The mainly came Asia, with proportion coming Hong Kong, 97.71% 92.11%, Metagenomic sequencing indicated that carried different regions Asia generally similar but showed some differences. Flies Southeast East South West harboured unique opportunistic capable causing gastrointestinal respiratory infections humans. Specifically, such as Campylobacter jejuni, Bacillus anthracis, Bacteroides fragilis, Bordetella bronchiseptica, while B. Clostridium tetani, cereus. Our findings provide support future risk assessments vectors.

Language: Английский

Citations

0
Gut bacterial type III secretion systems aggravate colitis in mice and serve as biomarkers of Crohn’s disease DOI Creative Commons
Jun Xu, Peijie Li, Zhenye Li

et al.

EBioMedicine, Journal Year: 2024, Volume and Issue: 107, P. 105296 - 105296

Published: Aug. 30, 2024

Language: Английский

Citations

1