Carcinogenetic mechanisms employed by the oral microbiome: a narrative review

The American Journal of the Medical Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Role of infectious agents in Cancer pathogenesis and therapy

The Microbe, Journal Year: 2025, Volume and Issue: unknown, P. 100284 - 100284

Published: March 1, 2025

Language: Английский

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Streptococcus anginosus Activates the NLRP3 Inflammasome to Promote Inflammatory Responses from Macrophages

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

Chronic inflammation and oral dysbiosis are common features of squamous cell carcinoma (OSCC). The commensal streptococci, S. anginosus, is increased in diseases including OSCC. Our previous work revealed that anginosus promotes inflammatory responses from macrophage lines, however the molecular mechanism by which interacts with macrophages to instigate this response remains be investigated. Here, we expand on our findings investigating effects infection primary bone marrow derived (BMMs) during vivo infection. We found activated BMMs, presented an enlarged cellular area, NF-κB activation downstream cytokines TNF⍰, IL-6 IL-1β at 24 hours post viability was dispensable for activation, but essential induction proteins cytokines. persisted intracellularly within BMMs induced expression inflammasome sensors AIM2, NLRC4 NLRP3. Further, lacking adapter protein ASC ( Asc -/- ) had significantly diminished production compared wild type indicating inflammasome. primarily triggered through NLRP3 as -infected Nlrp3 inhibitor (MCC950)-treated displayed controls. Lastly, mice reduced weight loss C57BL/6 mice. These overall indicate replicates a proinflammatory part brief summary sentence: sensed promote response.

Language: Английский

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Streptococcus anginosus: the potential role in the progression of gastric cancer

Journal of Cancer Research and Clinical Oncology, Journal Year: 2025, Volume and Issue: 151(4)

Published: April 19, 2025

Gastric cancer (GC) is among the most common and aggressive malignancies worldwide, characterized by a poor prognosis. Research on its pathogenesis progression continues to evolve. Streptococcus anginosus (S. anginosus, SA) Gram-positive coccus commonly found in oral cavity upper respiratory tract, serving as commensal bacterium oral, gastrointestinal, genitourinary tracts. It frequently associated with abscess formation various organs tissues, well other purulent infections. In recent years, S. has gained increasing attention for role GC progression, potentially leading chronic gastric inflammation precancerous lesions, ultimately promoting development of GC. Emerging evidence indicates strong association between malignant unfavorable prognosis This review summarizes underlying mechanisms proposes that plays pivotal initiation underscoring potential therapeutic significance.

Language: Английский

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Development of a Novel Multi‐Epitope Vaccine Against Streptococcus anginosus Infection via Reverse Vaccinology Approach

Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

ABSTRACT Streptococcus anginosus is an opportunistic pathogen known for its capability to cause a broad range of infections, posing significant and growing global health concern. Alongside enhancing diagnostic capabilities bolstering public initiatives, developing safe effective vaccine represents promising strategy tackle this challenge. In paper, we employed array bioinformatics tools engineer subunit that exhibits high immunogenicity against S. . After constructing the multi‐epitope vaccine, subsequently predicted secondary tertiary protein structures. refining validating modelled structure, utilised advanced computational approaches, including molecular docking dynamic simulations, evaluate binding affinity, compatibility, stability vaccine–adjuvant complexes. Eventually, in silico cloning was conducted optimise expression production. The developed showed properties antigenicity immunity theoretically. study revealed demonstrates efficacy

Language: Английский

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Autoimmune gastritis studies and gastric cancer: True renaissance or bibliometric illusion

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(32), P. 3783 - 3790

Published: Aug. 26, 2024

A bibliometric analysis of studies dedicated to autoimmune gastritis (AIG) recently published demonstrated a noteworthy surge in publications over the last three years. This can be explained by numerous from different regions world reporting results several that stimulated reassessment our view AIG as precancerous condition. Follow-up and retrospective analyses showed risk gastric cancer (GC) patients is much lower than expected if ever being infected with

Language: Английский

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Conjugated therapeutic proteins as a treatment for bacteria which trigger cancer development

iScience, Journal Year: 2024, Volume and Issue: 27(10), P. 111029 - 111029

Published: Sept. 26, 2024

Language: Английский

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Effect of a Novel Food Rich in Miraculin on the Oral Microbiome of Malnourished Oncologic Patients with Dysgeusia

Cancers, Journal Year: 2024, Volume and Issue: 16(19), P. 3414 - 3414

Published: Oct. 8, 2024

Dysgeusia contributes to the derangement of nutritional status in patients with cancer as well worsening quality life. There has been a lack effective treatments for taste disorders provided by pharmaceutical industry.

Language: Английский

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A pilot study of the relationship between salivary microbial characteristics and endocrine and immune function in patients with burning mouth syndrome

Clinical Oral Investigations, Journal Year: 2024, Volume and Issue: 29(1)

Published: Dec. 12, 2024

Language: Английский

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