Varicella virus: natural course, clinical manifestations, immunity, genetic diversity, current and future vaccination strategies DOI

Z. E. Alshimbayeva,

R.Kh. Begaydarova,

Irina Kadyrova

et al.

Medicine and ecology, Journal Year: 2025, Volume and Issue: 1, P. 30 - 38

Published: May 16, 2025

The causative agent of varicella virus is widespread. In children, especially with a complicated premorbid background, there high incidence severe forms and complications. Widespread use specific prophylaxis necessary. According to WHO estimates, 4.2 million registered cases complications chickenpox resulted in 4,200 deaths. Severe course virus, addition mortality are typical for newborns individuals impaired immune system. following were identified deceased patients virus: bacterial (55%), pneumonia (54%), hemorrhagic (41%), from the central nervous system (33%). genetic diversity plays key role its pathogenicity, epidemiology response vaccination. Despite successful vaccination programs, continues circulate population, which emphasizes need deep understanding diversity. Genetic varicella-zoster viruses may influence response, vaccine efficacy, making it an important subject research. Global research results this area highlight importance monitoring evolution developing effective treatment strategies. These be useful epidemiologists, immunologists, virologists, infectious disease specialists.

Language: Английский

PANDEMIC EPIDEMIOLOGY: A COMPREHENSIVE REVIEW OF COVID-19 LESSONS AND FUTURE HEALTHCARE PREPAREDNESS DOI Creative Commons

Olufunke Omotayo,

Muridzo Muonde,

Tolulope O Olorunsogo

et al.

International Medical Science Research Journal, Journal Year: 2024, Volume and Issue: 4(1), P. 89 - 107

Published: Jan. 23, 2024

This comprehensive review examines the epidemiology of COVID-19 pandemic, shedding light on pivotal lessons learned and their implications for future healthcare preparedness. Analyzing global landscape virus, delves into transmission dynamics, risk factors influencing severe outcomes, effectiveness diverse public health interventions. It provides a nuanced exploration challenges encountered by systems worldwide, elucidating strengths vulnerabilities brought to forefront pandemic. The study underscores need multifaceted approach preparedness, emphasizing critical importance integrated surveillance systems, agile response mechanisms, implementation evidence-based strategies. Drawing experiences from regions, identifies key in pandemic management, showcasing successful strategies innovative interventions that have proven effective curbing virus's spread. Moreover, role vaccination campaigns shaping trajectory emphasizes vital contribution technology bolstering resilience. As world grapples with long-term effects COVID-19, this aims distill essential insights can inform preparedness efforts. By synthesizing knowledge gleaned posed analysis offers foundation strategies, guiding towards enhanced readiness confront mitigate impact infectious threats. Keywords: Pandemic, Epidemiology, Healthcare, Review.

Language: Английский

Citations

12
A fully integrated microfluidic cartridge for rapid and ultrasensitive nucleic acid detection from oropharyngeal swabs DOI
Bao Li,

Baobao Lin,

Wu Zeng

et al.

Lab on a Chip, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Rapid and accurate molecular diagnostics are crucial for preventing the global spread of emerging infectious diseases. However, current gold standard nucleic acid detection, reverse transcription polymerase chain reaction (RT-PCR), relies heavily on traditional magnetic beads or silica membranes extraction, resulting in several limitations, including time-consuming processes, need trained personnel, complex equipment. Therefore, there is an urgent fully integrated detection technologies that simple to operate, rapid, highly sensitive meet unmet clinical needs. In this study, we developed a novel, microfluidic cartridge featuring unique needle-plug/piston microvalve, which enables stable long-term reagent storage flexible liquid handling on-site analysis. Coupled with

Language: Английский

Citations

1
Transforming molecular diagnostics learning: the power of gamification in higher medical education DOI Creative Commons
Hua Xing Zhu, Wei Zeng, Chen Li

et al.

Frontiers in Education, Journal Year: 2025, Volume and Issue: 10

Published: Feb. 20, 2025

Introduction Traditional teaching models in molecular diagnostics often fail to engage students effectively, leading superficial learning and limited development of core competencies. Methods This study evaluated the integration gamified with collaborative inquiry enhance student motivation competencies improvement among 47 biotechnology undergraduates at Guilin Medical University. Participants engaged a four-unit “Gene Detective” game, solving clinical cases through techniques, earning skill points, group discussions. Results Data from assessments, self-reported competency scales, final exam scores concurrent course, post-course questionnaires revealed significant improvements especially critical thinking, curiosity, creativity communication skill, positive correlation between game-based values academic performance. Over 88% reported high engagement, 79.6% increased interest. Discussion While hybrid model successfully promoted development, challenges enhancing providing individualized support were identified. The findings underscore potential gamification medical education highlight future directions, including AI-driven personalization refined tasks, optimize outcomes.

Language: Английский

Citations

1
Fast Track Diagnostic Tools for Clinical Management of Sepsis: Paradigm Shift from Conventional to Advanced Methods DOI Creative Commons
Ena Gupta, Juhi Saxena, Sanni Kumar

et al.

Diagnostics, Journal Year: 2023, Volume and Issue: 13(2), P. 277 - 277

Published: Jan. 11, 2023

Sepsis is one of the deadliest disorders in new century due to specific limitations early and differential diagnosis. Moreover, antimicrobial resistance (AMR) becoming dominant threat human health globally. The only way encounter spread emergence AMR through active detection identification pathogen along with quantification resistance. For better management such disease, there an essential requirement approach many suitable diagnostic techniques for proper administration antibiotics elimination these infectious diseases. current method employed diagnosis sepsis relies on conventional culture blood suspected infection. However, this more time consuming generates results that are false negative case antibiotic pretreated samples as well slow-growing microbes. In comparison method, modern methods capable analyzing samples, obtaining accurate from suspicious patient sepsis, giving all necessary information identify pathogens a short period. present review intended highlight shift advanced technologies including their prompt diagnosing bloodstream infections detection.

Language: Английский

Citations

21
Digital CRISPR systems for the next generation of nucleic acid quantification DOI Creative Commons
Anthony J. Politza, Reza Nouri, Weihua Guan

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 159, P. 116917 - 116917

Published: Jan. 6, 2023

Language: Английский

Citations

20
Epidemiology, pathogenesis, clinical characteristics, and treatment of mucormycosis: a review DOI Creative Commons

Mei Liang,

Jian Xu,

Yanan Luo

et al.

Annals of Medicine, Journal Year: 2024, Volume and Issue: 56(1)

Published: Sept. 2, 2024

Aim This review aims to summarize the epidemiology, etiology, pathogenesis, clinical manifestations, and current diagnostic therapeutic approaches for mucormycosis. The goal is improve understanding of mucormycosis promote early diagnosis treatment reduce mortality.

Language: Английский

Citations

7
Distribution and prevalence of enterotoxigenic Staphylococcus aureus and staphylococcal enterotoxins in raw ruminants’ milk: A systematic review DOI Creative Commons
Maha Shalaby, Julien Reboud, Taya Forde

et al.

Food Microbiology, Journal Year: 2023, Volume and Issue: 118, P. 104405 - 104405

Published: Oct. 18, 2023

Enterotoxins produced by Staphylococcus aureus are a common cause of food poisoning, leading to significant gastrointestinal symptoms and even hospitalization. Following the Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guidelines, we searched three electronic databases studies on detection staphylococcal enterotoxins or enterotoxigenic S. in raw ruminant milk. The 128 included this systematic review showed worldwide distribution aureus, with an increase number from 1980 2021, shift methods enterotoxin genes, preponderance Europe South America. Most focused milk individual animals mastitis, especially cattle. Based 24 studies, within-herd prevalence samples was 11.6%. Many failed report health status sampled animals, numerator denominator data needed calculation. Cultural legislative differences, economic status, diagnostic capabilities, public awareness all likely factors contributing observed studies. Our highlighted gap quality completeness reporting, which limits full assessment hazards posed

Language: Английский

Citations

16
Whole Genome Sequencing: Applications in Clinical Bacteriology DOI Creative Commons
Abu Salim Mustafa

Medical Principles and Practice, Journal Year: 2024, Volume and Issue: 33(3), P. 185 - 197

Published: Jan. 1, 2024

The success in determining the whole genome sequence of a bacterial pathogen was first achieved 1995 by complete nucleotide <i>Haemophilus influenzae</i> Rd using chain-termination method established Sanger et al. 1977 and automated Hood 1987. However, this technology laborious, costly, time-consuming. Since 2004, high-throughput next-generation sequencing technologies have been developed, which are highly efficient, require less time, cost-effective for (WGS) all organisms, including pathogens. In recent years, data obtained WGS coupled with bioinformatics analyses sequenced genomes projected to revolutionize clinical bacteriology. used identification species, strains, genotypes from cultured organisms directly specimens. has also helped resistance antibiotics detection antimicrobial genes point mutations. Furthermore, epidemiological tracking surveillance pathogenic bacteria healthcare settings as well communities. This review focuses on applications

Language: Английский

Citations

6
Toward Integrated Molecular Lateral Flow Diagnostic Tests Using Advanced Micro- and Nanotechnology DOI
Ana Rubio-Monterde, Daniel Quesada-González, Arben Merkoçi

et al.

Analytical Chemistry, Journal Year: 2022, Volume and Issue: 95(1), P. 468 - 489

Published: Nov. 22, 2022

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTToward Integrated Molecular Lateral Flow Diagnostic Tests Using Advanced Micro- and NanotechnologyAna Rubio-MonterdeAna Rubio-MonterdePaperdrop Diagnostics S.L., MRB, Campus UAB, 08193 Bellaterra, SpainNanobioelectronics Biosensors Group, Catalan Institute of Nanoscience Nanotechnology (ICN2), CSIC, Barcelona, SpainMore by Ana Rubio-MonterdeView Biographyhttps://orcid.org/0000-0003-0068-9621, Daniel Quesada-González*Daniel Quesada-GonzálezPaperdrop Spain*[email protected]More Quesada-GonzálezView Biographyhttps://orcid.org/0000-0003-3064-2146, Arben Merkoçi*Arben MerkoçiPaperdrop SpainThe Barcelona Science Technology (BIST), 08036 SpainICREA, Institució Catalana de Recerca i Estudis Avançats, Pg. Lluis Companys 23, 08010 MerkoçiView Biographyhttps://orcid.org/0000-0003-2486-8085Cite this: Anal. Chem. 2023, 95, 1, 468–489Publication Date (Web):November 22, 2022Publication History Received14 October 2022Published online22 November inissue 10 January 2023https://pubs.acs.org/doi/10.1021/acs.analchem.2c04529https://doi.org/10.1021/acs.analchem.2c04529review-articleACS PublicationsCopyright © 2022 American Chemical SocietyRequest reuse permissionsArticle Views1848Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence for given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Assays,Diagnostic imaging,Genetics,Immunology,Peptides proteins Get e-Alerts

Language: Английский

Citations

22
Clinical microbiology in detection and identification of emerging microbial pathogens: past, present and future DOI Creative Commons
Hui Wang, Wenhong Zhang, Yi‐Wei Tang

et al.

Emerging Microbes & Infections, Journal Year: 2022, Volume and Issue: 11(1), P. 2579 - 2589

Published: Sept. 19, 2022

Clinical microbiology has possessed a marvellous past, an important present and bright future. Western medicine modernization started with the discovery of bacterial pathogens, from then, clinical bacteriology became cornerstone diagnostics. Today, uses standard techniques including Gram stain morphology, in vitro culture, antigen antibody assays, molecular biology both to establish diagnosis monitor progression microbial infections. played critical role pathogen detection characterization for emerging infectious diseases as evidenced by ongoing COVID-19 pandemic. Revolutionary changes are on way application "-omic" techniques, transcriptomics metabolomics, optimization practice configurations improve outcomes patients diseases.

Language: Английский

Citations

21