Akkermansia muciniphila: A potential target and pending issues for oncotherapy DOI Creative Commons
Xu Zhao, Juanjuan Zhao, Dongmei Li

et al.

Pharmacological Research, Journal Year: 2023, Volume and Issue: 196, P. 106916 - 106916

Published: Sept. 9, 2023

In the wake of development metagenomic, metabolomic, and metatranscriptomic approaches, intricate interactions between host various microbes are now being progressively understood. Numerous studies have demonstrated evident changes in gut microbiota during process a variety diseases, such as diabetes, obesity, aging, cancers. Notably, is viewed potential source novel therapeutics. Currently, Next-generation probiotics (NGPs) gaining popularity therapeutic agents that alter affect cancer development. Akkermansia muciniphila (A. muciniphila), representative commensal bacterium, has received substantial attention over past decade promising NGP. The components metabolites A. can directly or indirectly tumorigenesis, particular through its effects on antitumor immunosurveillance, including stimulation pattern recognition receptors (PRRs), which also leads to better outcomes situations, prevention curation this article, we systematically summarize role tumorigenesis (involving gastrointestinal non-gastrointestinal cancers) tumor therapy. particular, carefully discuss some critical scientific issues need be solved for future using beneficial bacterium treatment, might provide bright clues assistance application drugs targeting clinical oncotherapy.

Language: Английский

Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms DOI
Patrice D. Cani, Clara Depommier, Muriel Derrien

et al.

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2022, Volume and Issue: 19(10), P. 625 - 637

Published: May 31, 2022

Language: Английский

Citations

618
Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course DOI Creative Commons
Xiaoyuan Zhou,

Ryan Baumann,

Xiaohui Gao

et al.

Cell, Journal Year: 2022, Volume and Issue: 185(19), P. 3467 - 3486.e16

Published: Sept. 1, 2022

Language: Английский

Citations

189
Akkermansia muciniphila as a Next-Generation Probiotic in Modulating Human Metabolic Homeostasis and Disease Progression: A Role Mediated by Gut–Liver–Brain Axes? DOI Open Access
Huafeng Jian, Yating Liu, Xiaoming Wang

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 3900 - 3900

Published: Feb. 15, 2023

Appreciation of the importance Akkermansia muciniphila is growing, and it becoming increasingly relevant to identify preventive and/or therapeutic solutions targeting gut–liver–brain axes for multiple diseases via muciniphila. In recent years, its components such as outer membrane proteins extracellular vesicles have been known ameliorate host metabolic health intestinal homeostasis. However, impacts on disease are complex, both potentially beneficial adverse effects mediated by derivatives, in some cases, these dependent upon physiology microenvironment forms, genotypes, strain sources Therefore, this review aims summarize current knowledge how interacts with influences homeostasis progression. Details will be discussed including biological genetic characteristics; functions anti-obesity, anti-diabetes, anti-metabolic-syndrome, anti-inflammation, anti-aging, anti-neurodegenerative disease, anti-cancer therapy functions; strategies elevate abundance. Key events referred specific states, should facilitate identification muciniphila-based probiotic axes.

Language: Английский

Citations

84
Recent findings in Akkermansia muciniphila-regulated metabolism and its role in intestinal diseases DOI
Mengjie Liu,

Jingyu Yang,

Zhenhua Yan

et al.

Clinical Nutrition, Journal Year: 2022, Volume and Issue: 41(10), P. 2333 - 2344

Published: Sept. 3, 2022

Language: Английский

Citations

81
Revisiting the role of Akkermansia muciniphila as a therapeutic bacterium DOI Creative Commons
Jiyeon Si, Hyena Kang,

Hyun Ju You

et al.

Gut Microbes, Journal Year: 2022, Volume and Issue: 14(1)

Published: May 25, 2022

Despite a short history since its first isolation, Akkermansia muciniphila has been extensively studied in relation to effects on human metabolism. A recent intervention study also demonstrated that the bacterium is safe use for therapeutic purposes. The best-known of A. health and disease relate ability strengthen gut integrity, modulate insulin resistance, protect host from metabolic inflammation. further molecular mechanism, induction GLP-1 secretion through ICAM-2 receptor, was recently discovered with identification new bacterial protein produced by muciniphila. However, other studies have suggested detrimental role specific immune settings. Here, we evaluate molecular, mechanistic suggest some missing links be connected before organism should considered as next-generation biotherapeutic agent.

Language: Английский

Citations

80
A genetic system for Akkermansia muciniphila reveals a role for mucin foraging in gut colonization and host sterol biosynthesis gene expression DOI
Lauren Davey,

Per Malkus,

Max M. Villa

et al.

Nature Microbiology, Journal Year: 2023, Volume and Issue: 8(8), P. 1450 - 1467

Published: June 19, 2023

Language: Английский

Citations

56
Novel tripeptide RKH derived fromAkkermansia muciniphilaprotects against lethal sepsis DOI
Shihao Xie, Jiaxin Li,

Fengyuan Lyu

et al.

Gut, Journal Year: 2023, Volume and Issue: 73(1), P. 78 - 91

Published: Aug. 8, 2023

Objective The pathogenesis of sepsis is complex, and the sepsis-induced systemic proinflammatory phase one key drivers organ failure consequent mortality. Akkermansia muciniphila (AKK) recognised as a functional probiotic strain that exerts beneficial effects on progression many diseases; however, whether AKK participates in still unclear. Here, we evaluated potential contribution to lethal development. Design Relative abundance gut microbial septic patients was evaluated. Cecal ligation puncture (CLP) surgery lipopolysaccharide (LPS) injection were employed establish mice. Non-targeted targeted metabolomics analysis used for metabolites analysis. Results We first found relative significantly reduced compared with non-septic controls. Live supplementation, well supplementation its culture supernatant, remarkably mortality models. Metabolomics germ-free mouse validation experiments revealed live able generate novel tripeptide Arg-Lys-His (RKH). RKH exerted protective against death damage. Furthermore, markedly inflammatory cell activation factor overproduction. A mechanistic study could directly bind Toll-like receptor 4 (TLR4) block TLR4 signal transduction immune cells. Finally, validated preventive inflammation damage piglet model. Conclusion tripeptide, RKH, derived from AKK, may act endogenous antagonist TLR4. serve therapeutic approach combat after successfully translating efficacy into clinical practice.

Language: Английский

Citations

48
Rational consideration of Akkermansia muciniphila targeting intestinal health: advantages and challenges DOI Creative Commons

Yuheng Luo,

Cong Lan,

Hua Li

et al.

npj Biofilms and Microbiomes, Journal Year: 2022, Volume and Issue: 8(1)

Published: Oct. 17, 2022

Abstract As one of the promising next-generation probiotics (NGPs), Akkermansia muciniphila , a well-known mucin-degrading bacterium, has been proven to be closely related metabolic diseases its human host. However, role A. in host’s intestinal health remains ambiguous. Here, we comprehensively summarize and discuss characteristics, distribution, colonization gastrointestinal tract (GIT). We propose that application as biomarker for longevity, diagnostics prognostics diseases, or should cautiously considered. Precise dietary regulation can mediate treatment by altering abundance . Although beneficial component inflammation discovered, gnotobiotic mice with specific gut microbiota, certain genotype, colorectal cancer, animal models infected pathogen, may occurrence development diseases. Genomic analysis, emphasizing strain-level phylogenetic differences indicates clear description discussion each strain is critical before practical application. Our review provides much needed insight precise

Language: Английский

Citations

56
Interspecies commensal interactions have nonlinear impacts on host immunity DOI Creative Commons
Tyler Rice,

Agata A. Bielecka,

Mytien Nguyen

et al.

Cell Host & Microbe, Journal Year: 2022, Volume and Issue: 30(7), P. 988 - 1002.e6

Published: May 30, 2022

Language: Английский

Citations

44
Experimental evaluation of ecological principles to understand and modulate the outcome of bacterial strain competition in gut microbiomes DOI Creative Commons
Rafael R. Segura Muñoz, Sara Mantz,

Inés Martínez

et al.

The ISME Journal, Journal Year: 2022, Volume and Issue: 16(6), P. 1594 - 1604

Published: Feb. 24, 2022

It is unclear if coexistence theory can be applied to gut microbiomes understand their characteristics and modulate composition. Through experiments in gnotobiotic mice with complex microbiomes, we demonstrated that strains of Akkermansia muciniphila Bacteroides vulgatus could only established were devoid these species. Strains A. showed strict competitive exclusion, while B. coexisted but populations still influenced by interactions. These differences behavior reflective genomic variation within the two species, indicating considerable niche overlap for a broader space strains. Priority effects detected both species as strains' fitness increased when colonizing first, which resulted stable persistence strain first exclusion arriving second. Based on observations, devised subtractive strategy using antibiotics from an assembled community stably replaced another strain. By demonstrating outcomes ecosystems depend are historically contingent, our study provides novel information explain ecological basis modulation.

Language: Английский

Citations

40