The Role and Mechanism of Probiotics Supplementation in Blood Glucose Regulation: A Review DOI Creative Commons

Xinyu Shen,

Chunmin Ma, Yang Yang

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(17), P. 2719 - 2719

Published: Aug. 27, 2024

With economic growth and improved living standards, the incidence of metabolic diseases such as diabetes mellitus caused by over-nutrition has risen sharply worldwide. Elevated blood glucose complications in patients seriously affect quality life increase burden. There are limitations side effects current hypoglycemic drugs, while probiotics, which safe, economical, effective, have good application prospects disease prevention remodeling intestinal microecological health gradually becoming a research hotspot for treatment, capable lowering alleviating complications, among other things. Probiotic supplementation is microbiologically based approach to treatment type 2 (T2DM), can achieve anti-diabetic efficacy through regulation different tissues pathways. In this study, we summarize recent findings that probiotic intake modulating flora, decreasing chronic low-grade inflammation, glucagon-like peptide-1 (GLP-1), oxidative stress, ameliorating insulin resistance, increasing short-chain fatty acids (SCFAs) content. Moreover, mechanism, application, development prospect, challenges probiotics regulating were discussed provide theoretical references guiding basis preparations related functional foods glucose.

Language: Английский

NAFLD/MASLD and the Gut–Liver Axis: From Pathogenesis to Treatment Options DOI Creative Commons
Natalia G. Vallianou, Dimitris Kounatidis,

Sotiria Psallida

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(7), P. 366 - 366

Published: June 28, 2024

Nonalcoholic fatty liver disease (NAFLD) poses an emerging threat topublic health. steatohepatitis (NASH) is reported to be the most rapidly rising cause of hepatocellular carcinoma in western world. Recently, a new term has been proposed: metabolic dysfunction-associated steatotic (MASLD). The introduction this terminology sparked debate about interchangeability these terms. pathogenesis NAFLD/MASLD thought multifactorial, involving both genetic and environmental factors. Among factors, alterations gut microbiota dysbiosis have recently garnered significant attention. In context, review will further discuss gut-liver axis, which refers bidirectional interaction between human liver. Additionally, therapeutic potential probiotics, particularly next-generation probiotics genetically engineered bacteria, explored. Moreover, role prebiotics, synbiotics, postbiotics, phages as well fecal transplantation analyzed. Particularly for lean patients with NAFLD/MASLD, who limited treatment options, approaches that modify diversity composition may hold promise. However, due ongoing safety concerns modulate microbiota, large-scale studies are necessary better assess their efficacy treating NAFLD/MASLD.

Language: Английский

Citations

22
Gut-liver axis: Pathophysiological concepts and medical perspective in chronic liver diseases DOI Creative Commons
Susana Rodrigues, Van der Merwe, Aleksander Krag

et al.

Seminars in Immunology, Journal Year: 2024, Volume and Issue: 71, P. 101859 - 101859

Published: Jan. 21, 2024

Language: Английский

Citations

18
Protection of Alzheimer’s disease progression by a human-origin probiotics cocktail DOI Creative Commons
Santosh Kumar Prajapati, Shaohua Wang, Sidharth Mishra

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 10, 2025

Microbiome abnormalities (dysbiosis) significantly contribute to the progression of Alzheimer's disease (AD). However, therapeutic efficacy microbiome modulators in protecting against these ailments remains poorly studied. Herein, we tested a cocktail unique probiotics, including 5 Lactobacillus and Enterococcus strains isolated from infant gut with proven modulating capabilities. We aimed determine probiotics cocktail's ameliorating AD pathology humanized mouse model APP/PS1 strains. Remarkably, feeding mice 1 × 1011 CFU per day drinking water for 16 weeks reduced cognitive decline (measured by Morris Water Maze test) markers, such as Aβ aggregation, microglia activation, neuroinflammation, preserved blood-brain barrier (BBB) tight junctions. The beneficial effects were linked inflammatory microbiome, leading decreased permeability inflammation both systemic circulation brain. Although male female showed overall improvements cognition biological females did not exhibit specific markers related permeability, suggesting that underlying mechanisms may differ depending on sex. In conclusion, our results suggest this could serve prophylactic agent reduce pathology. This is achieved beneficially improving intestinal junction proteins, reducing BBB, decreasing gut, blood circulation, brain, ultimately mitigating decline.

Language: Английский

Citations

3
Causal relationship between gut microbiota and ageing: A multi-omics Mendelian randomization study DOI

Guolin Zhang,

Yuqing Lu,

Zhenhong Wang

et al.

Archives of Gerontology and Geriatrics, Journal Year: 2025, Volume and Issue: 131, P. 105765 - 105765

Published: Jan. 20, 2025

Language: Английский

Citations

2
Non-alcoholic fatty liver disease and gut microbial dysbiosis- underlying mechanisms and gut microbiota mediated treatment strategies DOI
Muthukumaran Jayachandran, Shen Qu

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2023, Volume and Issue: 24(6), P. 1189 - 1204

Published: Oct. 16, 2023

Language: Английский

Citations

29
Beneficial, safety, and antioxidant properties of lactic acid bacteria: A next step in their evaluation as potential probiotics DOI Creative Commons
Ronaldo Rwubuzizi, Hamin Kim, Wilhelm H. Holzapfel

et al.

Heliyon, Journal Year: 2023, Volume and Issue: 9(4), P. e15610 - e15610

Published: April 1, 2023

The role of lactic acid bacteria (LAB) as probiotics health promoting factors for human or veterinary practice has gained increasing interest during the last three decades. This is reflected in screening approaches LAB strains line with minimal requirements a "probiotic" regard to safety and functionality. latter might also include natural antioxidant properties, thereby constituting an additional benefit substituting synthetic antioxidants. vitro assays conducted this study included scavenging 2,2-diphenyl-1-picrylhydrazil (DPPH) free radical, metal (Fe+2) ion chelation, determining properties hydroxyl superoxide radicals, anti-lipid peroxidation. Analysis DPPH radical property microorganisms current study, showed Streptococcus salivarius ST59HK exhibit highest activity at level 85.24%. greatest Fe+2 chelation 98.2% was recorded Str. ST62HK while lowest ST48HK 71.5%. levels were detected (98.6%) Lactiplantibacillus plantarum ST63HK (35.60%), respectively. Superoxide anion highly exhibited by ST61HK (54.62%) least Enterococcus faecium ST651ea (18.7%). Lastly, Lactobacillus gasseri ST16HK E. ST7319ea peroxidation 69.43% 26.15%, Anti-oxidative appear be strain specific thus some these could potentially applied antioxidants fermented food products.

Language: Английский

Citations

24
Altered gut microbiota of obesity subjects promotes colorectal carcinogenesis in mice DOI Creative Commons
Xing Kang,

Siu-Kin Ng,

Changan Liu

et al.

EBioMedicine, Journal Year: 2023, Volume and Issue: 93, P. 104670 - 104670

Published: June 19, 2023

Obesity is a risk factor for colorectal cancer (CRC). The role of gut microbiota in mediating the cancer-promoting effect obesity unknown.Azoxymethane (AOM)-treated, ApcMin/+ and germ-free mice were gavaged with feces from obese individuals control subjects respectively. colonic tumor load number recorded at endpoint two carcinogenic models. composition transcriptome assessed by metagenomic sequencing RNA sequencing, anticancer effects bacteria depleted fecal samples validated.Conventional AOM-treated receiving showed significantly increased colon formation compared those subjects. impaired intestinal barrier function significant upregulation pro-inflammatory cytokines activation oncogenic Wnt signaling pathway. Consistently, transferring to led cell proliferation, impairment, induction proinflammatory gene expression. Moreover, transplanted human donors had abundance potential pathobiont Alistipes finegoldii, reduced commensals Bacteroides vulgatus Akkermansia muciniphila normal body mass index (BMI). Validation experiments that B. A. demonstrated anti-proliferative CRC, while finegoldii promoted CRC growth.Our results supported obesity-associated carcinogenesis identified putative bacterial candidates may mediate its mechanisms. Microbiota modulation provide new approaches prevent or treat obesity-related cancers including CRC.This work was funded National Key Research Development Program China (2020YFA0509200/2020YFA0509203), Natural Science Foundation (81922082), RGC Theme-based Scheme Hong Kong (T21-705/20-N), Impact Fund (R4632-21F), RGC-CRF (C4039-19GF C7065-18GF), RGC-GRF (14110819, 14111621), NTU Start-Up Grant (021337-00001).

Language: Английский

Citations

24
Gut Microbiota and Biomarkers of Intestinal Barrier Damage in Cirrhosis DOI Creative Commons

Irina Efremova,

Roman Maslennikov, Medvedev Os

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(3), P. 463 - 463

Published: Feb. 25, 2024

Gut dysbiosis and subclinical intestinal damage are common in cirrhosis. The aim of this study was to examine the association biomarkers (diamine oxidase [DAO], claudin 3, fatty acid binding protein [I-FABP; FABP2]) with state gut microbiota blood levels DAO were inversely correlated lipopolysaccharide (LPS), presepsin, TNF-α, severity cirrhosis according Child–Pugh scores. level I-FABP directly 3 but not that DAO. Patients small bacterial overgrowth (SIBO) had lower than patients without SIBO. There no significant difference detection rates between abundance Akkermansiaceae, Akkermansia, Allisonella, Clostridiaceae, Dialister, Lactobacillus, Muribaculaceae, Negativibacillus, Ruminococcus, Thiomicrospiraceae, Verrucomicrobiae, Verrucomicrobiota; it Anaerostipes, Erysipelatoclostridium, Vibrio. Bacteroidia, Bacteroidota, Bilophila, Megamonas, Selenomonadaceae; Brucella, Pseudomonadaceae, Pseudomonas, Vibrionaceae. Anaerostipes Coriobacteriia, Eggerthellaceae, Lactobacillus.

Language: Английский

Citations

14
Akkermansia muciniphila : A promising probiotic against inflammation and metabolic disorders DOI Creative Commons
Yanqing Zhao, Huijun Yang, Peng Wu

et al.

Virulence, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 27, 2024

Metabolic disease is a worldwide epidemic that has become public health problem. Gut microbiota considered to be one of the important factors maintain human by regulating host metabolism. As an abundant bacterium in gut,

Language: Английский

Citations

13
The microbiota: a crucial mediator in gut homeostasis and colonization resistance DOI Creative Commons
Yiding Chen, Ling Xiao, Min Zhou

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 6, 2024

The gut microbiota is a complex and diverse community of microorganisms that colonizes the human gastrointestinal tract influences various aspects health. These microbes are closely related to enteric infections. As foreign entity for host, commensal restricted regulated by barrier immune system in contributes homeostasis. Commensals also effectively resist colonization pathogens overgrowth indigenous pathobionts utilizing variety mechanisms, while have developed strategies subvert resistance. Dysbiosis microbial can lead acts as pivotal mediator establishing harmonious mutualistic symbiosis with host shielding against pathogens. This review aims provide comprehensive overview mechanisms underlying host-microbiome microbiome-pathogen interactions, highlighting multi-faceted roles preventing We discuss applications manipulating treat infectious diseases gut.

Language: Английский

Citations

11