Influence of Seasonality and Public-Health Interventions on the COVID-19 Pandemic in Northern Europe

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(2), P. 334 - 334

Published: Jan. 6, 2024

Most government efforts to control the COVID-19 pandemic revolved around non-pharmaceutical interventions (NPIs) and vaccination. However, many respiratory diseases show distinctive seasonal trends. In this manuscript, we examined contribution of these three factors progression pandemic.

Language: Английский

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Respiratory Virus Season Surveillance in the United States Using Wastewater Metrics, 2023–2024

ACS ES&T Water, Journal Year: 2025, Volume and Issue: 5(2), P. 985 - 992

Published: Jan. 22, 2025

Wastewater measurements represent an entire contributing population and can be available within 24 h. Enhanced information about disease occurrence improve health through better timing of policies interventions. We aimed to infer seasonal patterns for common respiratory viruses alongside transmission dynamics SARS-CoV-2 across the USA using wastewater samples. used RNA concentrations influenza A B (IAV/IBV), syncytial virus (RSV), human metapneumovirus (HMPV), from 175 treatment plants (July 2023–June 2024). For IAV, IBV, RSV, HMPV, we determined epidemic onset, offset, peak, duration at national subnational scales. SARS-CoV-2, categorized based on recent levels trends. Epidemic onset occurred in November IAV RSV which aligned with prepandemic norms. Onset January IBV April HMPV were later than expected according historical data. Duration was longer shorter peak dates consistent norms all viruses. Peak coincided high, upward trending concentrations, suggesting potential co-occurrence these

Language: Английский

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Barriers and Facilitators to Successful Outbreak Management of Viral Respiratory Tract Infections in Long-Term Care Facilities: A Qualitative Interview Study

Journal of the American Medical Directors Association, Journal Year: 2025, Volume and Issue: 26(6), P. 105575 - 105575

Published: April 15, 2025

Effective management of COVID-19 and influenza outbreaks in nursing homes (NHs) depends on preparation by the NH organization rightful execution infection prevention control (IPC) measures staff. To be better prepared for future pandemics, we need a understanding barriers facilitators to measures. This study aims investigate which were perceived Dutch staff during IPC pandemic end stage. Qualitative interview study. Nursing where and/or (defined as at least 2 confirmed cases an unit) occurred between February 2023 April 2023. We monitored 24 14 organizations Purposive sampling was used select variety more extensive monitoring, including qualitative interviews with involved outbreak. During interviews, participants reflected well previous outbreaks. Interview transcripts thematically analyzed identify determinants strategy execution. Determinants clustered according themes: motivations attitudes; appropriateness measures; guidance cooperation staff; communication; knowledge skills; architectural features location; availability resources. The current provides in-depth insight into facilitated impeded These findings may help NHs prepare provide insights what consider developing strategies.

Language: Английский

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Seasonal forcing and waning immunity drive the sub-annual periodicity of the COVID-19 epidemic

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

Seasonal trends in infectious diseases are shaped by climatic and social factors, with many respiratory viruses peaking winter. However, the seasonality of COVID-19 remains dispute, significant waves cases across United States occurring both winter summer. Using wavelet analysis cases, we find that periodicity epidemic varies markedly U.S. correlates temperatures, indicating seasonal forcing. pattern multiple per year has been so disruptive unique to cannot be explained a modified SIRS model allows specification tempo waning immunity, show specific forms non-durable immunity can sufficiently explain sub-annual characteristic epidemic.

Language: Английский

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Second booster doses of adenoviral- and mRNA-based COVID-19 vaccines increase protection against COVID-19 hospitalization: Final analysis from the REFORCO-Brazil real-world effectiveness study during Omicron

Vaccine, Journal Year: 2025, Volume and Issue: 53, P. 126955 - 126955

Published: March 10, 2025

Language: Английский

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COVID-19 Disease Burden in the Omicron Variant-Dominated Endemic Phase: Insights from the ROUTINE-COV19 Study Using Real-World German Statutory Health Insurance Data

Viruses, Journal Year: 2025, Volume and Issue: 17(3), P. 424 - 424

Published: March 14, 2025

The ROUTINE-COV19 study explores the burden of COVID-19 in Germany during early endemic phase, assessing disease patterns and their impact on healthcare system from 1 July 2022 to 30 June 2023. Using anonymized statutory health insurance data over 3 million individuals Thuringia Saxony, cases were identified through diagnostic codes, with severe critical defined by hospitalization intensive care criteria. focused high-risk populations as German Immunization Technical Advisory Group. During period, 414,648 new documented, peaks October March Severe occurred at a rate 241.6 per 100,000 persons, in-hospital mortality exceeding 12%. Critical requiring had an 32.2%. COVID-19-related hospitalizations averaged 9.94 days, generating direct costs EUR 64.9 million, while indirect work absenteeism amounted 454.3 representing 7.5% all-cause costs. Despite entering continues pose substantial burden, particularly among older adults those pre-existing cardiovascular conditions.

Language: Английский

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The prognostic value of Clinical Frailty Scale in COVID-19 pneumonia across different pandemic phases: a comparison between the first and the fourth wave

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 27, 2025

Introduction The COVID-19 pandemic has placed unprecedented strain on health-care systems. Frailty is being used in clinical decision making for patients with COVID-19, yet the prevalence and effect of frailty people may be influenced by local characteristics each wave. We aimed to establish older who were admitted hospital investigate its association mortality comparing non-vaccinated first wave versus vaccinated fourth Materials methods This was an observational study conducted at one single center Italy. All adults (≥70 years) confirmed (positive molecular testing) included. Data 658 (493 during 165 against wave), collected from records including symptom type, extension lung abnormalities chest computed tomography (CT), laboratory parameters. assessed Clinical Scale (CFS) grouped according their score (≤4: fit or pre-frail; 5–6 = initial signs but some degree independence; >7 severe very frailty). primary outcome in-hospital mortality. Results In comparison wave, unvaccinated had reduced heart disease (35% vs. 56%), renal failure (9% 15%), higher fever time diagnosis (84% 59%), malignancy (16% 6%), (CT) severity visual score, CRP (C-reactive protein) serum levels (median value 105 mg/L 75 mg/L), lower burden frailty. a stepwise multivariable logistic regression model, risk death regardless CFS [Odds Ratio (OR) 2.241, 95% confidence interval (CI) 1.492–3.336, p < 0.001], while significantly associated Conclusion Our suggests that unable stratify death.

Language: Английский

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Age, gender, and race differences in nasal morphology: Linking air conditioning and filtration efficiency to disparities in air pollution health outcomes and COVID-19 mortality

Chemosphere, Journal Year: 2025, Volume and Issue: 377, P. 144358 - 144358

Published: March 29, 2025

Language: Английский

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Sample-Sparing Multiplexed Antibody Fc Biomarker Discovery Using a Reconfigurable Integrated Microfluidic Platform

Lab on a Chip, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The μMAP chip takes a drop of sample and generates deep humoral immune profile (1400 readouts) antigen-specific antibody Fab Fc profiles enabling biomarker discovery for distinguishing disease states including current past infection.

Language: Английский

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Optimal Timing of Vaccination: A Narrative Review of Integrating Strategies for COVID-19, Influenza, and Respiratory Syncytial Virus

Infectious Diseases and Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Lower respiratory tract infections caused by SARS-CoV-2, influenza, and syncytial virus (RSV) cause a significant disease burden globally, despite the availability of effective vaccines. Certain populations, such as older adults (≥ 60 years) individuals all ages with particular comorbidities, are at increased risk for severe outcomes, including hospitalization death. National administration schedules available vaccines against viruses not unified, current guidelines clear directive, concerning optimal timing vaccination. Herein, we formulate an evidence-based position regarding COVID-19, RSV vaccination chronic based on synthesis literature guidelines. Vaccination impact were found to be influenced vaccinee factors, age waning vaccine effectiveness seasonal pathogen burden. Because display unique patterns within between regions, local epidemiological surveillance each is crucial determining To maximize benefits these vaccines, peak period greatest outcomes should aligned. Thus, other recommended given ahead start season (or regionally appropriate time) co-administered single, routine visit represent approach protecting at-risk populations. More data will required establish clinical benefit additional doses whether may integrated schedule. Coordinated policy decisions that align strain selection new annually reformulated would enable timely raising public health awareness, ultimately leading enhanced uptake. Implementation strategies require engagement healthcare providers strong, recommendations schedules.

Language: Английский

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