Colonization with the enteric protozoa Blastocystis is associated with increased diversity of human gut bacterial microbiota DOI Creative Commons
Christophe Audebert, Gaël Even,

Amandine Cian

et al.

Scientific Reports, Journal Year: 2016, Volume and Issue: 6(1)

Published: May 5, 2016

Abstract Alterations in the composition of commensal bacterial populations, a phenomenon known as dysbiosis, are linked to multiple gastrointestinal disorders, such inflammatory bowel disease and irritable syndrome, or infections by diverse enteric pathogens. Blastocystis is one most common single-celled eukaryotes detected human faecal samples. However, clinical significance this widespread colonization remains unclear, its pathogenic potential controversial. To address issue pathogenicity, we investigated impact protist on gut microbiota. For that purpose, conducted cross-sectional study including 48 -colonized patients -free subjects performed an Ion Torrent 16S rDNA gene sequencing decipher -associated Here, report higher diversity microbiota colonized patients, abundance Clostridia well lower Enterobacteriaceae. Our results contribute suggesting usually associated with healthy microbiota, rather than dysbiosis generally observed metabolic infectious diseases tract.

Language: Английский

Connecting the immune system, systemic chronic inflammation and the gut microbiome: The role of sex DOI
Lisa Rizzetto, Francesca Fava, Kieran Tuohy

et al.

Journal of Autoimmunity, Journal Year: 2018, Volume and Issue: 92, P. 12 - 34

Published: June 1, 2018

Language: Английский

Citations

275
Commensal orthologs of the human autoantigen Ro60 as triggers of autoimmunity in lupus DOI Open Access
Teri M. Greiling, Carina Dehner, Xinguo Chen

et al.

Science Translational Medicine, Journal Year: 2018, Volume and Issue: 10(434)

Published: March 28, 2018

Commensal bacterial orthologs of the human autoantigen Ro60 may trigger cross-reactive T and B cells that initiate sustain chronic autoimmunity in lupus.

Language: Английский

Citations

274
Gut Microbiota in Human Systemic Lupus Erythematosus and a Mouse Model of Lupus DOI Open Access
Xin Luo, Michael Edwards,

Qinghui Mu

et al.

Applied and Environmental Microbiology, Journal Year: 2017, Volume and Issue: 84(4)

Published: Dec. 1, 2017

ABSTRACT Gut microbiota dysbiosis has been observed in a number of autoimmune diseases. However, the role gut systemic lupus erythematosus (SLE), prototypical disease characterized by persistent inflammation multiple organs body, remains elusive. Here we report dynamics murine model, NZB/W F1, as well intestinal small group SLE patients with active disease. The composition changed markedly before and after onset F1 mice, greater diversity increased representation several bacterial species progressed from predisease stage to diseased stage. did not control for age cage effect. Using dexamethasone an intervention treat SLE-like signs, also found that abundance lactobacilli (for which assignment could be made) might correlated more severe mice. Results human study suggest that, compared subjects without immune-mediated diseases, possessed altered differed particular (within genera Odoribacter Blautia unnamed genus family Rikenellaceae ) was less diverse, Gram-negative bacteria. Firmicutes / Bacteroidetes ratios differ between non-SLE our cohort. IMPORTANCE is complex no known cure. Dysbiosis reported both mice humans SLE. In this emerging field, however, studies are required delineate roles different lupus-prone mouse models people diverse manifestations Here, changes

Language: Английский

Citations

261
Partners in Leaky Gut Syndrome: Intestinal Dysbiosis and Autoimmunity DOI Creative Commons

Yusuke Kinashi,

Koji Hase

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: April 22, 2021

The intestinal surface is constitutively exposed to diverse antigens, such as food food-borne pathogens, and commensal microbes. Intestinal epithelial cells have developed unique barrier functions that prevent the translocation of potentially hostile antigens into body. Disruption increases permeability, resulting in leaky gut syndrome (LGS). Clinical reports suggested LGS contributes autoimmune diseases type 1 diabetes, multiple sclerosis, rheumatoid arthritis, celiac disease. Furthermore, microbiota plays a critical role regulating host immunity; abnormalities microbial community, known dysbiosis, are observed patients with diseases. However, pathological links among LGS, not been fully elucidated. This review discusses current understanding how pathogenesis by modifying barrier.

Language: Английский

Citations

252
Colonization with the enteric protozoa Blastocystis is associated with increased diversity of human gut bacterial microbiota DOI Creative Commons
Christophe Audebert, Gaël Even,

Amandine Cian

et al.

Scientific Reports, Journal Year: 2016, Volume and Issue: 6(1)

Published: May 5, 2016

Abstract Alterations in the composition of commensal bacterial populations, a phenomenon known as dysbiosis, are linked to multiple gastrointestinal disorders, such inflammatory bowel disease and irritable syndrome, or infections by diverse enteric pathogens. Blastocystis is one most common single-celled eukaryotes detected human faecal samples. However, clinical significance this widespread colonization remains unclear, its pathogenic potential controversial. To address issue pathogenicity, we investigated impact protist on gut microbiota. For that purpose, conducted cross-sectional study including 48 -colonized patients -free subjects performed an Ion Torrent 16S rDNA gene sequencing decipher -associated Here, report higher diversity microbiota colonized patients, abundance Clostridia well lower Enterobacteriaceae. Our results contribute suggesting usually associated with healthy microbiota, rather than dysbiosis generally observed metabolic infectious diseases tract.

Language: Английский

Citations

242