International Journal of Molecular Sciences,
Journal Year:
2019,
Volume and Issue:
20(19), P. 4871 - 4871
Published: Sept. 30, 2019
Systemic
lupus
erythematosus
(SLE)
is
an
autoimmune
disease
featuring
enhanced
expression
of
type
I
interferon
(IFN)
and
autoantibody
production
triggering
inflammation
of,
damage
to,
multiple
organs.
Continuing
research
efforts
focus
on
how
gut
microbes
trigger
systemic
autoimmunity
SLE.
The
microbial
communities
mice
humans
with
have
been
investigated
via
high-throughput
sequencing.
Firmicutes-to-Bacteroidetes
ratio
consistently
reduced
in
SLE
patients,
regardless
ethnicity.
relative
abundance
Lactobacillus
differs
from
the
animal
model
used
(MRL/lpr
or
NZB/W
F1
mice).
This
may
indicate
that
interactions
between
host,
rather
than
enrichment
certain
microbes,
are
especially
significant
terms
development.
Enterococcus
gallinarum
reuteri,
both
which
possible
pathobionts,
become
translocated
into
tissue
if
epithelial
barrier
impaired.
then
interact
host
immune
systems,
activating
IFN
pathway
inducing
production.
In
addition,
molecular
mimicry
critically
link
microbiome
to
Gut
commensals
patients
share
protein
epitopes
Ro60
autoantigen.
Ruminococcus
gnavus
strain
cross-reacted
native
DNA,
anti-double-stranded
DNA
antibody
response.
Expansion
R.
paralleled
increase
activity
nephritis.
Such
insights
microbiota
enhance
our
understanding
pathogenesis
will
identify
biomarkers
predicting
active
disease.
Science,
Journal Year:
2020,
Volume and Issue:
369(6506), P. 936 - 942
Published: Aug. 21, 2020
Phages
and
cancer
immunity
Gut
bacteria
are
involved
in
the
education
of
T
cell
immune
responses,
intestinal
ecosystem
influences
anticancer
immunity.
Fluckiger
et
al.
report
microbial
antigens
that
might
cross-react
with
associated
tumor
cells.
They
found
a
type
called
enterococci
harbor
bacteriophage
modulates
responses.
In
mouse
models,
administration
containing
boosted
responses
after
treatment
chemotherapy
or
programmed
death
protein
1
(PD-1)
blockade.
humans,
presence
was
improved
survival
PD-1
immunotherapy.
A
fraction
human
cells
specific
for
naturally
processed
melanoma
epitopes
appeared
to
be
able
recognize
peptides.
This
“molecular
mimicry”
may
represent
cross-reactivity
between
tumors
antigens.
Science
,
this
issue
p.
936
Journal of Autoimmunity,
Journal Year:
2018,
Volume and Issue:
97, P. 77 - 87
Published: Nov. 9, 2018
Alterations
in
the
microbiota
composition
of
gastro-intestinal
tract
are
suspected
to
be
involved
etiopathogenesis
two
closely
related
systemic
inflammatory
autoimmune
diseases:
primary
Sjögren's
syndrome
(pSS)
and
lupus
erythematosus
(SLE).
Our
objective
was
assess
whether
alterations
gut
oral
compositions
specific
for
pSS
SLE.16S
ribosomal
RNA
gene
sequencing
performed
on
fecal
samples
from
39
patients,
30
SLE
patients
965
individuals
general
population,
as
well
buccal
swab
washing
same
patients.
Alpha-diversity,
beta-diversity
relative
abundance
individual
bacteria
were
used
outcome
measures.
Multivariate
analyses
test
associations
between
disease
phenotype,
taking
age,
sex,
body-mass
index,
proton-pump
inhibitor
use
sequencing-depth
into
account
possible
confounding
factors.Fecal
differed
significantly
population
controls,
but
not
SLE.
characterized
by
lower
bacterial
richness,
Firmicutes/Bacteroidetes
ratio
higher
Bacteroides
species
compared
with
controls.
Oral
which
could
partially
explained
dryness
patients.pSS
share
similar
composition,
distinguishing
while
shows
disease-specific
differences
