Induction of PD-1 and CD44 in CD4 + T cells by circulatory extracellular vesicles from severe dengue patients drives endothelial damage via the NF-kB signaling pathway DOI Creative Commons

Sharda Kumari,

Amlan Biswas, Tushar Kanti Maiti

et al.

Journal of Virology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 31, 2024

Extracellular vesicles (EVs) emerged as critical contributors to the pathogenesis of vascular endothelial barrier dysfunction during inflammatory response infection. However, contribution circulating EVs modifying function dengue virus infection remains unclear. In this study, we showed that severe patients' plasma-derived EV (SD-EV) were found carry elevated levels different protein cargos, e.g., immunoregulatory proteins (PD-L1, CD44). Further, demonstrated SD-EV induces PD-1 and CD44 expression on CD4

Language: Английский

Role of extracellular vesicles in the pathogenesis of mosquito-borne flaviviruses that impact public health DOI Creative Commons
Pedro Pablo Martínez-Rojas,

Verónica Monroy-Martínez,

Blanca H. Ruíz-Ordaz

et al.

Journal of Biomedical Science, Journal Year: 2025, Volume and Issue: 32(1)

Published: Jan. 4, 2025

Abstract Mosquito-borne flaviviruses represent a public health challenge due to the high-rate endemic infections, severe clinical outcomes, and potential risk of emerging global outbreaks. Flavivirus disease pathogenesis converges on cellular factors from vectors hosts, their interactions are still unclear. Exosomes microparticles extracellular vesicles released cells that mediate intercellular communication necessary for maintaining homeostasis; however, they have been shown be involved in establishment progression. This review focuses roles mosquito-borne flavivirus diseases: how contribute viral cycle completion, cell-to-cell transmission, responses such as inflammation, immune suppression, evasion, well use biomarkers or therapeutics (antiviral vaccines). We highlight current findings concerning functionality different models dengue virus, Zika yellow fever Japanese encephalitis West Nile virus infections diseases. The available evidence suggests diverse functions between constituting novel effectors understanding pathogenic mechanisms flaviviral

Language: Английский

Citations

1
Extracellular Vesicles: A Crucial Player in the Intestinal Microenvironment and Beyond DOI Open Access
Shumeng Wang, Junyi Luo, Hailong Wang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3478 - 3478

Published: March 20, 2024

The intestinal ecological environment plays a crucial role in nutrient absorption and overall well-being. In recent years, research has focused on the effects of extracellular vesicles (EVs) both physiological pathological conditions intestine. intestine does not only consume EVs from exogenous foods, but also those other endogenous tissues cells, even gut microbiota. alteration microbiota subsequently gives rise to changes organs systems, including central nervous system (CNS), namely microbiome-gut-brain axis, which exhibits significant involvement EVs. This review first an overview generation isolation techniques EVs, then mainly focuses elucidating functions derived various origins microenvironment, as well impacts altered microenvironment systems. Lastly, we discuss microbial cellular axis. enhances understanding specific roles system, thereby promoting more effective treatment strategies for certain associated diseases.

Language: Английский

Citations

4
A game of hide-and-seek: how extracellular vesicles evade the immune system DOI Creative Commons
Bartika Ghoshal, Siddharth Jhunjhunwala

Drug Delivery and Translational Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Language: Английский

Citations

0
Extracellular vesicles in arbovirus infections: from basic biology to potential clinical applications DOI Creative Commons
Natalia Tiberti, Concetta Castilletti, Federico Gobbi

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: April 28, 2025

Arthropod-borne viruses, or arboviruses, are currently considered a global health threat responsible for potentially severe human diseases. The increased population density, changes in land use and climate change some of the factors that contributing to spread these infections over last years. pathogenesis diseases mechanisms interaction with host, especially those leading development forms, yet be fully understood. In recent years extracellular vesicles (EVs) have emerged as important players inter-cellular host-pathogen arising lot interest also field vector-borne viruses. this context, EVs seem play dual role, by either promoting, thus facilitating, preventing infection. Many studies showing how viruses can hijack vesiculation machinery escape host immune response exploit sustain their replication propagation, even though shed cells essential promote antiviral responses. manuscript we reviewed current knowledge regarding association between paying particular attention possible role disease transmission dissemination, well potential novel tools clinical applications, spanning from biomarkers utility therapeutic options.

Language: Английский

Citations

0
Extracellular Vesicles in Pathophysiology: A Prudent Target That Requires Careful Consideration DOI Creative Commons
Sanjay Shahi, Taeyoung Kang, Pamali Fonseka

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(9), P. 754 - 754

Published: April 26, 2024

Extracellular vesicles (EVs) are membrane-bound particles released by cells to perform multitudes of biological functions. Owing their significant implications in diseases, the pathophysiological role EVs continues be extensively studied, leading research neglect need explore normal physiology. Despite this, many identified physiological functions EVs, including, but not limited to, tissue repair, early development and aging, attributed modulatory various signaling pathways via intercellular communication. widely perceived as a potential therapeutic strategy for better prognosis, primarily through utilization mode delivery vehicle. Moreover, disease-associated serve candidates targeted inhibition pharmacological or genetic means. However, these attempts often accompanied major challenges, such off-target effects, which may result adverse phenotypes. This renders clinical efficacy elusive, indicating that further understanding specific physiology enhance utility. review highlights essential maintaining cellular homeostasis under different settings, also discusses aspects potentially hinder robust utility EV-based therapeutics.

Language: Английский

Citations

3
Neutrophils – an understudied bystander in dengue? DOI

Caroline Lin Lin Chua,

Raika Francesca Morales,

Po Ying Chia

et al.

Trends in Microbiology, Journal Year: 2024, Volume and Issue: 32(11), P. 1132 - 1142

Published: May 14, 2024

Language: Английский

Citations

2
Dual Role of Extracellular Vesicles as Orchestrators of Emerging and Reemerging Virus Infections DOI

A. P. Athira,

S. Sreekanth,

Ananthu Chandran

et al.

Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 3, 2024

Language: Английский

Citations

1
Induction of PD-1 and CD44 in CD4 + T cells by circulatory extracellular vesicles from severe dengue patients drives endothelial damage via the NF-kB signaling pathway DOI Creative Commons

Sharda Kumari,

Amlan Biswas, Tushar Kanti Maiti

et al.

Journal of Virology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 31, 2024

Extracellular vesicles (EVs) emerged as critical contributors to the pathogenesis of vascular endothelial barrier dysfunction during inflammatory response infection. However, contribution circulating EVs modifying function dengue virus infection remains unclear. In this study, we showed that severe patients' plasma-derived EV (SD-EV) were found carry elevated levels different protein cargos, e.g., immunoregulatory proteins (PD-L1, CD44). Further, demonstrated SD-EV induces PD-1 and CD44 expression on CD4

Language: Английский

Citations

0