Emerging role of gut microbiota extracellular vesicle in neurodegenerative disorders and insights on their therapeutic management DOI Creative Commons
Adil Hassan, Yin Huang,

Mahjabina

et al.

iMetaOmics., Journal Year: 2024, Volume and Issue: 1(2)

Published: Oct. 25, 2024

Abstract Targeting gut flora to lower sickness risk is a growing scientific subject. The intricate network of microorganisms (gut microbiota) in the human intestines regulates many physiological systems and may be important for general health. Recent research has shown dynamic relationship between microbiota central nervous system (CNS). Dysbiosis key establishing progressing diseases, including neurodegenerative disorders. Recently, extracellular vesicles (GMEVs) have been suggested as brain‐gut communication carriers. Vesicle components contact immune receptors, initiating neuroinflammatory responses causing diseases. This study seeks explain how its cause or worsen We also highlighted recent advances our understanding these GMEVs' cargo's routes, which could used drug delivery treatments. examines current state potential therapeutic effects GMEVs on illnesses.

Language: Английский

Interplay Between Gut Microbiota and Exosome Dynamics in Sleep Apnea DOI

R.R Hicks,

David Gozal, Sadia Ahmed

et al.

Sleep Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 106493 - 106493

Published: April 1, 2025

Language: Английский

Citations

0
Biogenesis of DNA-carrying extracellular vesicles by the dominant human gut methanogenic archaeon DOI Creative Commons
Diana P. Baquero, Guillaume Borrel, Anastasia D. Gazi

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 22, 2024

ABSTRACT Extracellular vesicles (EVs) are membrane-bound particles secreted by cells from all domains of life and implicated in a variety important processes, intercellular communication to pathogenesis. Here, we characterize EVs produced the dominant human gut methanogen, Methanobrevibacter smithii , which, unlike most archaea, contains peptidoglycan cell wall. Using quantitative proteomics, show that M. enriched various proteins responsible for chromatin structure, including histones, DNA repair. Consistently, carry DNA, with fragments covering entire cellular chromosome. Notably, strongly extrachromosomal circular (eccDNA) molecules which originate excision 2.9-kb chromosomal fragment proviral genome. The eccDNA encodes two key methanogenesis enzymes could boost their expression inside through gene dosage effect. Furthermore, four top ten abundant EV methanogenesis. Cryo-electron tomography (Cryo-ET) suggests formed budding membrane trapped under wall prior liberation local disruptions Collectively, our results reveal parallels biogenesis bacteria suggest facilitate export both viral as well metabolic environment, potential impact on methane production.

Language: Английский

Citations

1
Role of Extracellular Vesicles in Crohn’s Patients on Adalimumab Who Received COVID-19 Vaccination DOI Open Access
Maria De Luca, Biagia Musio, Francesco Balestra

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8853 - 8853

Published: Aug. 14, 2024

Crohn’s disease (CD) is a type of inflammatory bowel (IBD) affecting the gastrointestinal tract that can also cause extra-intestinal complications. Following exposure to mRNA vaccine BNT162b2 (Pfizer-BioNTech) encoding SARS-CoV-2 Spike (S) protein, some patients experienced lack response biological drug Adalimumab and recrudescence disease. In CD in progression, resistant considered therapy, an abnormal increase intestinal permeability was observed, more often with modulated expression different proteins such as Aquaporin 8 (AQP8) tight junctions (e.g., ZO-1, Claudin1, Claudin2, Occludin), especially during flares. The aim this study investigate how could interfere IBD therapy contribute exacerbation. We investigated role transported by extracellular vesicles (EVs), impact various EVs components, namely, exosomes (EXOs) microvesicles (MVs), modulating molecules involved exacerbation CD, which remains unknown.

Language: Английский

Citations

0
Emerging role of gut microbiota extracellular vesicle in neurodegenerative disorders and insights on their therapeutic management DOI Creative Commons
Adil Hassan, Yin Huang,

Mahjabina

et al.

iMetaOmics., Journal Year: 2024, Volume and Issue: 1(2)

Published: Oct. 25, 2024

Abstract Targeting gut flora to lower sickness risk is a growing scientific subject. The intricate network of microorganisms (gut microbiota) in the human intestines regulates many physiological systems and may be important for general health. Recent research has shown dynamic relationship between microbiota central nervous system (CNS). Dysbiosis key establishing progressing diseases, including neurodegenerative disorders. Recently, extracellular vesicles (GMEVs) have been suggested as brain‐gut communication carriers. Vesicle components contact immune receptors, initiating neuroinflammatory responses causing diseases. This study seeks explain how its cause or worsen We also highlighted recent advances our understanding these GMEVs' cargo's routes, which could used drug delivery treatments. examines current state potential therapeutic effects GMEVs on illnesses.

Language: Английский

Citations

0