Multivalent mRNA Vaccine Elicits Broad Protection against SARS-CoV-2 Variants of Concern DOI Creative Commons

Monika Kumari,

Kang-Hao Liang,

Shih-Chieh Su

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(7), P. 714 - 714

Published: June 26, 2024

SARS-CoV-2 new waves are primarily caused by changes to the spike protein (S), which can substantially decrease efficacy of vaccines. Therefore, we tested several multivalent mRNA-LNP vaccines, targeting full-length S proteins different variants, and identified an optimal combination for protection against VOCs in BALB/c mice. The formulations included trivalent (WT + BA.5 XBB.1.5), pentavalent XBB.1.5 BQ.1.1 CH.1.1), octavalent CH.1.1 Alpha Delta BA.2) Among these vaccine showed superior almost all variants. Despite this, each elicited greater broad-spectrum neutralizing antibodies than previously evaluated bivalent BA.5). Subsequently, redesigned efficiently generate recent VOCs, including EG.5.1. Immunization with EG.5.1 XBB.1.16 BA.5) moderate levels Omicron VOCs. Results suggest that neutralization activity vaccines is better those WT Moreover, developed may be highly useful

Language: Английский

Fourth dose of microneedle array patch of SARS-CoV-2 S1 protein subunit vaccine elicits robust long-lasting humoral responses in mice DOI
Eun Kim,

Juyeop Shin,

Alessandro Ferrari

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 129, P. 111569 - 111569

Published: Feb. 9, 2024

Language: Английский

Citations

3
Multivalent mRNA Vaccine Elicits Broad Protection against SARS-CoV-2 Variants of Concern DOI Creative Commons

Monika Kumari,

Kang-Hao Liang,

Shih-Chieh Su

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(7), P. 714 - 714

Published: June 26, 2024

SARS-CoV-2 new waves are primarily caused by changes to the spike protein (S), which can substantially decrease efficacy of vaccines. Therefore, we tested several multivalent mRNA-LNP vaccines, targeting full-length S proteins different variants, and identified an optimal combination for protection against VOCs in BALB/c mice. The formulations included trivalent (WT + BA.5 XBB.1.5), pentavalent XBB.1.5 BQ.1.1 CH.1.1), octavalent CH.1.1 Alpha Delta BA.2) Among these vaccine showed superior almost all variants. Despite this, each elicited greater broad-spectrum neutralizing antibodies than previously evaluated bivalent BA.5). Subsequently, redesigned efficiently generate recent VOCs, including EG.5.1. Immunization with EG.5.1 XBB.1.16 BA.5) moderate levels Omicron VOCs. Results suggest that neutralization activity vaccines is better those WT Moreover, developed may be highly useful

Language: Английский

Citations

2