Resveratrol reduces obesity in high-fat diet-fed mice via modulating the composition and metabolic function of the gut microbiota

Free Radical Biology and Medicine, Journal Year: 2020, Volume and Issue: 156, P. 83 - 98

Published: April 16, 2020

Language: Английский

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Gut Microbiota, Host Organism, and Diet Trialogue in Diabetes and Obesity

Frontiers in Nutrition, Journal Year: 2019, Volume and Issue: 6

Published: March 13, 2019

The gastrointestinal tract with its microbiota is a complex, open and integrated ecosystem high environmental exposure. It widely accepted that the healthy gut essential for host homeostasis immunostasis, harboring an enormous number variety of microorganisms genes tailored by hundreds exogenous intrinsic factors. occurrence dysbiosis may contribute to vulnerability progression large spectrum infectious non-communicable diseases, including diabetes obesity, two metabolic disorders are showing endemic trend nowadays. There urgent need develop efficient strategies prevent treat such as obesity which areoften associated serious complications. In this paper, we give overview on implications in diabesity, focus triangle – diet - metabolism way manipulate microbial towards achieving novel diagnosis predictive biomarkers final goal re-establishing condition. current research data regarding precision/personalized nutrition suggest dietary interventions, administration pre-, pro-, synbiotics, well antibiotic treatment should be individually chronic diseases based genetic background, food beverage consumption, nutrient intake, microbiome, metabolome other omic profiles.

Language: Английский

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Dietary compounds and traditional Chinese medicine ameliorate type 2 diabetes by modulating gut microbiota

Critical Reviews in Food Science and Nutrition, Journal Year: 2018, Volume and Issue: 59(6), P. 848 - 863

Published: Dec. 20, 2018

Diabetes mellitus (DM) and its complications are major public health concerns which strongly influence the quality of humans' life. Modification gut microbiota has been widely used for management diabetes. In this review, relationship between diabetes microbiota, as well effects different dietary components traditional Chinese medicine (TCM) on microflora summarized. Dietary compounds TCM possessing bioactive (fiber phytochemicals) first change composition (inhibiting pathogens promoting beneficial bacteria growth) then production their metabolites, would further modify intestinal environment through inhibiting detrimental (such lipopolysaccharide, hydrogen sulfide, indol, etc.). Importantly, metabolites (short chain fatty acids other components) fermented/degraded by can target multiple pathways in intestine, liver, pancreas, etc., resulting improvement health, glycemic control, lipids profile, insulin resistance inflammation. Furthermore, understanding interaction underlying mechanisms help design diet formula Further researches could focus combination preventing treating diabetes, based principle "multiple against targets" from perspective microbiota.

Language: Английский

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Lactobacillus acidophilus alleviates type 2 diabetes by regulating hepatic glucose, lipid metabolism and gut microbiota in mice

Food & Function, Journal Year: 2019, Volume and Issue: 10(9), P. 5804 - 5815

Published: Jan. 1, 2019

Lactobacillus acidophilus alleviates type 2 diabetes induced by a high fat diet and streptozotocin (STZ) injection regulating gut microbiota, hepatic glucose lipid metabolism in mice.

Language: Английский

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Impact of Gut Microbiota and Microbiota-Related Metabolites on Hyperlipidemia

Frontiers in Cellular and Infection Microbiology, Journal Year: 2021, Volume and Issue: 11

Published: Aug. 19, 2021

Hyperlipidemia, defined as the presence of excess fat or lipids in blood, has been considered a high-risk factor and key indicator many metabolic diseases. The gut microbiota reported playing vital role regulating host lipid metabolism. pathogenic development hyperlipidemia revealed through fecal transplantation experiment to germ-free mice. effector mechanism microbiota-related metabolites such bile acids, lipopolysaccharide, short-chain fatty acids regulation partially unveiled. Moreover, studies on gut-microbiota-targeted interventions, including use prebiotics, probiotics, transplantation, natural herbal medicines, also have shown their efficacy treatment hyperlipidemia. In this review, we summarize relationship between hyperlipidemia, impact progression potential therapeutic management targeted at microbiota.

Language: Английский

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Gut Microbiota and Type 2 Diabetes Mellitus: Association, Mechanism, and Translational Applications

Mediators of Inflammation, Journal Year: 2021, Volume and Issue: 2021, P. 1 - 12

Published: Aug. 17, 2021

Gut microbiota has attracted widespread attention due to its crucial role in disease pathophysiology, including type 2 diabetes mellitus (T2DM). Metabolites and bacterial components of gut affect the initiation progression T2DM by regulating inflammation, immunity, metabolism. Short-chain fatty acids, secondary bile acid, imidazole propionate, branched-chain amino lipopolysaccharide are main molecules related T2DM. Many studies have investigated T2DM, particularly those butyrate-producing bacteria. Increasing evidence demonstrated that fecal transplantation probiotic capsules useful strategies preventing diabetes. In this review, we aim elucidate complex association between metabolism, immune disorders, underlying mechanisms, translational applications microbiota. This review will provide novel insight into developing individualized therapy for patients based on immunometabolism.

Language: Английский

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Gut microbiota: A new target of traditional Chinese medicine for insomnia

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 160, P. 114344 - 114344

Published: Feb. 2, 2023

All species have a physiological need for sleep, and sleep is crucial the preservation restoration of many processes in body. Recent research on effects gut microbiota brain function has produced essential data relationship between them. It been discovered that dysregulation gut-brain axis related to insomnia. Certain metabolites linked insomnia, disturbances can worsen Traditional Chinese medicine (TCM) unique advantages treatment Taking as target determining scientific relevance TCM prevention insomnia may lead new concepts disorders improve therapeutic effect sleep. an entry point, this paper reviews TCM, mechanism by which regulate regulates treatment. This review provides ideas through drug development.

Language: Английский

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Gut microbiota modulation with long-chain corn bran arabinoxylan in adults with overweight and obesity is linked to an individualized temporal increase in fecal propionate

Microbiome, Journal Year: 2020, Volume and Issue: 8(1)

Published: Aug. 19, 2020

Abstract Background Variability in the health effects of dietary fiber might arise from inter-individual differences gut microbiota’s ability to ferment these substrates into beneficial metabolites. Our understanding what drives this individuality is vastly incomplete and will require an ecological perspective as microbiomes function complex inter-connected communities. Here, we performed a parallel two-arm, exploratory randomized controlled trial 31 adults with overweight class-I obesity characterize long-chain, arabinoxylan ( n = 15) at high supplementation doses (female: 25 g/day; male: 35 g/day) on microbiota composition short-chain fatty acid production compared microcrystalline cellulose 16, non-fermentable control), integrated findings using framework. Results Arabinoxylan resulted global shift fecal bacterial community composition, reduced α-diversity, promotion specific taxa, including operational taxonomic units related Bifidobacterium longum , Blautia obeum Prevotella copri . further increased propionate concentrations p 0.012, Friedman’s test), effect that showed two distinct groupings temporal responses participants. The groups compositional shifts ≤ 0.025, PERMANOVA), multiple linear regression (MLR) analyses revealed response was predictable through and, lesser degree, baseline microbiota. Principal components (PCs) derived data were better predictors MLR models single indicating fermentation result multi-species interactions within microbiomes. Conclusion This study long-chain modulates both output health-relevant SCFAs, providing information for more targeted application fiber. Variation linked PCs microbial showing strongest associations. These constitute proof-of-concept merit framework considers features wider prediction metabolic outcomes fermentation. provides basis personalize use nutritional stratify human populations by relevant account inconsistent intervention studies. Trial registration Clinicaltrials.gov, NCT02322112 registered July 3, 2015.

Language: Английский

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Role of gut microbiota in identification of novel TCM-derived active metabolites

Protein & Cell, Journal Year: 2020, Volume and Issue: 12(5), P. 394 - 410

Published: Sept. 15, 2020

Traditional Chinese Medicine (TCM) has been extensively used to ameliorate diseases in Asia for over thousands of years. However, owing a lack formal scientific validation, the absence information regarding mechanisms underlying TCMs restricts their application. After oral administration, TCM herbal ingredients frequently are not directly absorbed by host, but rather enter intestine be transformed gut microbiota. The microbiota is microbial community living animal intestines, and functions maintain host homeostasis health. Increasing evidences indicate that herbs closely affect composition, which associated with conversion components into active metabolites. These may significantly therapeutic activity TCMs. Microbiota analyses, conjunction modern multiomics platforms, can together identify novel functional metabolites form basis future research.

Language: Английский

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Antidiabetic Effects of Gegen Qinlian Decoction via the Gut Microbiota are Attributable to Its Key Ingredient Berberine

Genomics Proteomics & Bioinformatics, Journal Year: 2020, Volume and Issue: 18(6), P. 721 - 736

Published: Dec. 1, 2020

Abstract Gegen Qinlian Decoction (GQD), a traditional Chinese medicine (TCM) formula, has long been used for the treatment of common metabolic diseases, including type 2 diabetes mellitus. However, main limitation its wider application is ingredient complexity this formula. Thus, it critically important to identify major active ingredients GQD and illustrate mechanisms underlying action. Here, we compared effects berberine, hypothetical key pharmaceutical GQD, on diabetic rat model by comprehensive analyses gut microbiota, short-chain fatty acids, proinflammatory cytokines, ileum transcriptomics. Our results show that berberine had similar lowering blood glucose levels, modulating inducing ileal gene expression, as well relieving systemic local inflammation. As expected, both significantly altered overall microbiota structure enriched many butyrate-producing bacteria, Faecalibacterium Roseburia, thereby attenuating intestinal inflammation glucose. Levels acids in feces were also elevated after with or GQD. Moreover, concentration serum cytokines expression immune-related genes, Nfkb1, Stat1, Ifnrg1, pancreatic islets reduced treatment. study demonstrates can be attributed via microbiota. The strategy employed would facilitate further standardization widespread TCM diseases.

Language: Английский

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