Role of symbiotic microbiota dysbiosis in the progression of chronic kidney disease accompanied with vascular calcification DOI Creative Commons
Meng‐Ying Sun,

Yilong Fang,

Jianhua Zheng

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 5, 2024

Background: Chronic kidney disease (CKD) is now globally recognized as a critical public health concern. Vascular calcification (VC) represents significant risk factor for cardiovascular events in individuals with CKD. It the accessible and precise diagnostic biomarkers monitoring progression of CKD concurrent VC are urgently needed. Methods: The adenine diet-induced rat model was utilized to investigate chronic injury, thoracic aorta, dysregulation biochemical indices. Enzyme-linked immune sandwich assays were employed analyze changes calcification-related proteins. 16S rRNA sequencing performed delineate microbiota characteristics gut blood CKD-afflicted rats. Additionally, transcriptome tissue conducted explore relationship between CKD-associated features alterations function. Results: inhibited body weight gain, led pronounced aorta. both these affected rats exhibited significantly lower alpha diversity distinctive beta than those their healthy counterparts. resulted several indices (including elevated levels creatinine, low-density lipoprotein-cholesterol, sodium, phosphorous, total cholesterol, urea decreased albumin, calcium, lactate dehydrogenase, bilirubin). Moreover, it upregulated factors (bone sialoprotein [BSP], Klotho, fibroblast growth [FGF]-23, sclerostin [SOST]) lipopolysaccharide (LPS). Notably, increased Acinetobacter positively associated calcifications addition positive correlation microbiota. enrichment increases (BSP, FGF-23, SOST), LPS, phosphorous. Furthermore, revealed that correlated majority genes negatively downregulated involved mineral absorption pathway. Conclusion: Our findings, first time, underscore dysbiosis symbiotic microbiota, blood, Particularly, emerges potential its accompanying VC.

Language: Английский

The Role of Short Chain Fatty Acids in Inflammation and Body Health DOI Open Access

Yuhang Du,

Changhao He, Yongcheng An

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7379 - 7379

Published: July 5, 2024

Short chain fatty acids (SCFAs), mainly including acetate, propionate and butyrate, are produced by intestinal bacteria during the fermentation of partially digested indigestible polysaccharides. SCFAs play an important role in regulating energy metabolism maintaining homeostasis environment also regulatory organs tissues outside gut. In recent years, many studies have shown that can regulate inflammation affect host health, two main signaling mechanisms been identified: activation G-protein coupled receptors (GPCRs) inhibition histone deacetylase (HDAC). addition, a growing body evidence highlights importance every SCFA influencing health maintenance disease development. this review, we summarized advances concerning biological properties their pathways health. Hopefully, it provide systematic theoretical basis for nutritional prevention treatment human diseases.

Language: Английский

Citations

47
Bacteroides vulgatus Ameliorates Lipid Metabolic Disorders and Modulates Gut Microbial Composition in Hyperlipidemic Rats DOI Creative Commons

Mingchao Xu,

Ruiting Lan, Lei Qiao

et al.

Microbiology Spectrum, Journal Year: 2023, Volume and Issue: 11(1)

Published: Jan. 10, 2023

As a core microbe of the human gut ecosystem, Bacteroides vulgatus has been linked to multiple aspects metabolic disorders in collection associative studies, which, while indicative, warrants more direct experimental evidence verify. In this study, we experimentally demonstrated that oral administration B. Bv46 ameliorated serum lipid profile and systemic inflammation high-fat diet-induced hyperlipidemic rats microbiome-regulated manner, which appears be associated with changes bile acid metabolism, short-chain fatty biosynthesis, metabolomic profile.

Language: Английский

Citations

46
The emerging role of the small intestinal microbiota in human health and disease DOI Creative Commons

Renate A.A.A. Ruigrok,

Rinse K. Weersma, Arnau Vich Vila

et al.

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(1)

Published: April 19, 2023

The human gut microbiota continues to demonstrate its importance in health and disease, largely owing the countless number of studies investigating fecal microbiota. Underrepresented these studies, however, is role played by microbial communities found small intestine, which, given essential function intestine nutrient absorption, host metabolism, immunity, likely highly relevant. This review provides an overview methods used study composition dynamics along different sections intestine. Furthermore, it explores facilitating physiological functions discusses how disruption equilibrium can influence disease development. evidence suggests that intestinal important regulator characterization has potential greatly advance microbiome research development novel diagnostics therapeutics.

Language: Английский

Citations

44
Curcumin modulated gut microbiota and alleviated renal fibrosis in 5/6 nephrectomy-induced chronic kidney disease rats DOI Creative Commons
Li Cheng, Xulong Chen, Jingchun Yao

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0314029 - e0314029

Published: Jan. 9, 2025

Increasing evidence suggests that dysbiosis of gut microbiota exacerbates chronic kidney disease (CKD) progression. Curcumin (CUR) has been reported to alleviate renal fibrosis in animal models CKD. However, the relationship between CUR and microbiome CKD remains unclear. This study aims investigate potential anti-renal effects from perspective. A 5/6 nephrectomy (5/6Nx) rat model was used explore therapeutic effect on fibrosis. Tight junction protein expression levels were measured assess intestinal barrier function. 16S rRNA sequencing employed evaluate changes composition, metabolomics utilized detect alterations plasma metabolites. The administration significantly ameliorated inhibited inflammation 5/6Nx rats. Additionally, markedly improved tight proteins local colon inflammation. also positively reconstructed microbiota, increasing abundance beneficial bacteria, such as Lachnospiraceae_NK4A136_group , Eubacterium_siraeum_group Muribaculaceae increased. Metabolomics revealed reduced uremic retention solutes elevated Vitamin D short-chain fatty acids (SCFAs). Spearman correlation analysis indicated genera enriched by correlated with SCFA negatively injury biomarkers. Mechanistically, we found inhibition LPS/TLR4/NF-κB TGF-β1/Smads pathway CUR-treated Our indicates modulate this modulation may contribute anti-fibrosis CUR.

Language: Английский

Citations

2
The oral-gut microbiota axis: a link in cardiometabolic diseases DOI Creative Commons
Qian Xu, Wenting Wang, Yiwen Li

et al.

npj Biofilms and Microbiomes, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 10, 2025

Language: Английский

Citations

2
Probiotic-fermented rice buckwheat alleviates high-fat diet-induced hyperlipidemia in mice by suppressing lipid accumulation and modulating gut microbiota DOI
Jing Yan,

Qiuyan Xue,

Chen Wen-yi

et al.

Food Research International, Journal Year: 2022, Volume and Issue: 155, P. 111125 - 111125

Published: March 12, 2022

Language: Английский

Citations

59
Exploring the gut microbiota: lifestyle choices, disease associations, and personal genomics DOI Creative Commons
Sharlize Pedroza Matute, Sasitaran Iyavoo

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: Oct. 5, 2023

The gut microbiota is a rich and dynamic ecosystem that actively interacts with the human body, playing significant role in state of health disease host. Diet, exercise, mental health, other factors have exhibited ability to influence bacterial composition, leading changes can prevent improve, or favor worsen, both intestinal extra-intestinal conditions. Altered microbial states, ‘dysbiosis’, associated conditions diseases are often characterized by shifts abundance diversity, including an impaired Firmicutes Bacteroidetes ratio. By understanding effect lifestyle on microbiota, personalized advice be generated suit each individual profile foster adoption ameliorate dysbiosis. delivery effective reliable advice, however, depends not only available research current topic, but also methods used assess individuals discover associations, which introduce bias at multiple stages. aim this review summarize how variability defined what choices shown association composition. Furthermore, popular investigate outlined, focus possible caused lack use standardized methods. Finally, overview based testing presented, underlining its power limitations.

Language: Английский

Citations

39
Treatment of Dyslipidemia through Targeted Therapy of Gut Microbiota DOI Open Access

Brandon Flaig,

Rachel Garza,

Bhavdeep Singh

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(1), P. 228 - 228

Published: Jan. 2, 2023

Dyslipidemia is a multifaceted condition with various genetic and environmental factors contributing to its pathogenesis. Further, this represents an important risk factor for related sequalae including cardiovascular diseases (CVD) such as coronary artery disease (CAD) stroke. Emerging evidence has shown that gut microbiota their metabolites can worsen or protect against the development of dyslipidemia. Although there are currently numerous treatment modalities available lifestyle modification pharmacologic interventions, been promising research on dyslipidemia involves benefits modulating in treating alterations lipid metabolism. In review, we examine relationship between dyslipidemia, impact current dietary prebiotics, probiotics, synbiotics transplant therapeutic prevention disease. Overall, understanding mechanisms by which affect progression will help develop more precise targets optimize

Language: Английский

Citations

31
Non-alcoholic fatty liver disease and gut microbial dysbiosis- underlying mechanisms and gut microbiota mediated treatment strategies DOI
Muthukumaran Jayachandran, Shen Qu

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2023, Volume and Issue: 24(6), P. 1189 - 1204

Published: Oct. 16, 2023

Language: Английский

Citations

31
Ginsenoside Rb1, Compound K and 20(S)-Protopanaxadiol Attenuate High-Fat Diet-Induced Hyperlipidemia in Rats via Modulation of Gut Microbiota and Bile Acid Metabolism DOI Creative Commons

Kang-Xi Zhang,

Yue Zhu,

Shuxia Song

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(5), P. 1108 - 1108

Published: March 1, 2024

Hyperlipidemia, characterized by elevated serum lipid concentrations resulting from metabolism dysfunction, represents a prevalent global health concern. Ginsenoside Rb1, compound K (CK), and 20(S)-protopanaxadiol (PPD), bioactive constituents derived Panax ginseng, have shown promise in mitigating disorders. However, the comparative efficacy underlying mechanisms of these compounds hyperlipidemia prevention remain inadequately explored. This study investigates impact ginsenoside CK, PPD supplementation on rats induced high-fat diet. Our findings demonstrate that Rb1 significantly decreased body weight gain, ameliorated hepatic steatosis, improved dyslipidemia HFD-fed rats, outperforming CK PPD. Moreover, distinctly modified gut microbiota composition function. increased relative abundance Blautia Eubacterium, while Akkermansia levels. Both Prevotella Bacteroides, whereas Clostridium-sensu-stricto Lactobacillus were reduced following treatment with all three compounds. Notably, only enhanced modulating PPARγ/ACC/FAS signaling pathway promoting fatty acid β-oxidation. Additionally, ginsenosides markedly bile enterohepatic circulation via FXR/CYP7A1 pathway, reducing total acids pool decreasing primary/unconjugated (CA, CDCA, β-MCA) increasing conjugated (TCDCA, GCDCA, GDCA, TUDCA), correlated changes. In conclusion, our results suggest offer promising prebiotic interventions for managing HFD-induced demonstrating superior efficacy.

Language: Английский

Citations

9