Smart capsules for sensing and sampling the gut: status, challenges and prospects DOI Creative Commons
Muhammad Rehan, Ibrahim Al‐Bahadly, David G. Thomas

et al.

Gut, Journal Year: 2023, Volume and Issue: 73(1), P. 186 - 202

Published: Sept. 21, 2023

Smart capsules are developing at a tremendous pace with promise to become effective clinical tools for the diagnosis and monitoring of gut health. This field emerged in early 2000s successful translation an endoscopic capsule from laboratory prototype commercially viable device. Recently, this has accelerated expanded into various domains beyond imaging, including measurement physiological parameters such as temperature, pH, pressure gas sensing, development sampling devices better insight In review, status smart sensing is presented provide broad picture these state-of-the-art while focusing on technical challenges need overcome realise their value settings. developed perform operations throughout length understand body’s response under conditions. Furthermore, prospects discussed that might help readers, especially health practitioners, adapt inevitable transformation healthcare. As compliment capsules, significant amount effort been put robotic collect tissue biopsy microbiota samples in-depth analysis after retrieval which will be game changer diagnosis, advancement also covered review. The expansion collection opened new avenues research great revolutionise human intervention.

Language: Английский

Dietary fat, bile acid metabolism and colorectal cancer DOI
Soeren Ocvirk, Stephen J. O’Keefe

Seminars in Cancer Biology, Journal Year: 2020, Volume and Issue: 73, P. 347 - 355

Published: Oct. 16, 2020

Language: Английский

Citations

176
Dysbiosis of human gut microbiome in young-onset colorectal cancer DOI Creative Commons
Yongzhi Yang, Lutao Du,

Debing Shi

et al.

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: Nov. 19, 2021

Abstract The incidence of sporadic young-onset colorectal cancer (yCRC) is increasing. A significant knowledge gap exists in the gut microbiota and its diagnostic value for yCRC patients. Through 16S rRNA gene sequencing, 728 samples are collected to identify microbial markers, an independent cohort 310 used validate results. Furthermore, species-level functional analysis performed by metagenome sequencing using 200 samples. Gut diversity increased yCRC. Flavonifractor plautii important bacterial species yCRC, while genus Streptococcus contains key phylotype old-onset cancer. Functional reveals that has unique characteristics metabolism characterized dominance DNA binding RNA-dependent biosynthetic process. random forest classifier model achieves a powerful classification potential. This study highlights potential biomarkers as promising non-invasive tool accurate detection distinction individuals with

Language: Английский

Citations

164
Reference materials for MS-based untargeted metabolomics and lipidomics: a review by the metabolomics quality assurance and quality control consortium (mQACC) DOI Creative Commons
Katrice A. Lippa, Juan J. Aristizabal‐Henao, Richard D. Beger

et al.

Metabolomics, Journal Year: 2022, Volume and Issue: 18(4)

Published: April 1, 2022

Abstract Introduction The metabolomics quality assurance and control consortium (mQACC) is enabling the identification, development, prioritization, promotion of suitable reference materials (RMs) to be used in (QA) (QC) for untargeted research. Objectives This review aims highlight current RMs, methodologies within lipidomics communities ensure standardization results obtained from data analysis, interpretation cross-study, cross-laboratory comparisons. essence also applicable other ‘omics areas that generate high dimensional data. Results potential game-changing biochemical discoveries through mass spectrometry-based (MS) are predicated on evolution more confident qualitative (and eventually quantitative) research laboratories. RMs thus critical QC tools able assure standardization, comparability, repeatability reproducibility interpretation, compare across studies multiple Standard operating procedures (SOPs) promote, describe exemplify use will improve communities. Conclusions application described this may significantly support continued development deployment new together with interlaboratory educational outreach training, further promote sound QA practices community.

Language: Английский

Citations

84
Microbiome and metabolome features in inflammatory bowel disease via multi-omics integration analyses across cohorts DOI Creative Commons
Lijun Ning, Yilu Zhou, Han Sun

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Nov. 6, 2023

Abstract The perturbations of the gut microbiota and metabolites are closely associated with progression inflammatory bowel disease (IBD). However, inconsistent findings across studies impede a comprehensive understanding their roles in IBD potential as reliable diagnostic biomarkers. To address this challenge, here we comprehensively analyze 9 metagenomic 4 metabolomics cohorts from different populations. Through cross-cohort integrative analysis (CCIA), identify consistent characteristic commensal microbiota. Especially, three bacteria, namely Asaccharobacter celatus , Gemmiger formicilis Erysipelatoclostridium ramosum which rarely reported IBD. Metagenomic functional reveals that essential gene Two-component system pathway, linked to fecal calprotectin, implicated Metabolomics shows 36 identified significant differences, while these still unknown. further elucidate relationship between metabolites, construct multi-omics biological correlation (MOBC) maps, highlights microbial biotransformation deficiencies alterations aminoacyl-tRNA synthetases. Finally, biomarkers for diagnosis, validated multiple global (AUROC values ranging 0.92 0.98). Our results offer valuable insights resource developing mechanistic hypotheses on host-microbiome interactions

Language: Английский

Citations

70
The diagnostic and prognostic potential of gut bacteria in inflammatory bowel disease DOI Creative Commons
Dickson Kofi Wiredu Ocansey,

Sanhua Hang,

Xinyi Yuan

et al.

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(1)

Published: Feb. 16, 2023

The gut microbiome serves as a signaling hub that integrates environmental inputs with genetic and immune signals to influence the host's metabolism immunity. Gut bacteria are intricately connected human health disease state, specific species driving characteristic dysbiosis found in gastrointestinal conditions such inflammatory bowel (IBD); thus, changes could be harnessed improve IBD diagnosis, prognosis, treatment. advancement next-generation sequencing techniques 16S rRNA whole-genome shotgun has allowed exploration of complexity microbial ecosystem high resolution. Current data is promising appears perform better some studies than currently used fecal inflammation biomarker, calprotectin, predicting from healthy controls irritable syndrome (IBS). This study reviews current on differential potential within cohorts, between other diseases.

Language: Английский

Citations

43
The Detrimental Impact of Ultra-Processed Foods on the Human Gut Microbiome and Gut Barrier DOI Open Access
D. Rondinella, Pauline Raoul,

Eleonora Valeriani

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 859 - 859

Published: Feb. 28, 2025

Ultra-processed foods (UPFs) have become a widely consumed food category in modern diets. However, their impact on gut health is raising increasing concerns. This review investigates how UPFs the microbiome and barrier, emphasizing dysbiosis increased permeability. UPFs, characterized by high content of synthetic additives emulsifiers, low fiber content, are associated with decrease microbial diversity, lower levels beneficial bacteria like Akkermansia muciniphila Faecalibacterium prausnitzii, an increase pro-inflammatory microorganisms. These alterations community contribute to persistent inflammation, which various chronic disorders including metabolic syndrome, irritable bowel type 2 diabetes, colorectal cancer. In addition, may alter gut-brain axis, potentially affecting cognitive function mental health. Dietary modifications incorporating fiber, fermented foods, probiotics can help mitigate effects UPFs. Furthermore, public needs stricter regulations for banning along well-defined labels. Further studies necessary elucidate mechanisms connecting systemic illnesses, thereby informing evidence-based dietary guidelines.

Language: Английский

Citations

2
Fusobacterium nucleatum Acts as a Pro-carcinogenic Bacterium in Colorectal Cancer: From Association to Causality DOI Creative Commons
Shuang Wang, Yang Liu, Jun Li

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2021, Volume and Issue: 9

Published: Aug. 20, 2021

Colorectal cancer (CRC) is a common worldwide with complex etiology. Fusobacterium nucleatum ( F. ), an oral symbiotic bacterium, has been linked CRC in the past decade. A series of gut microbiota studies show that patients carry high abundance tumor tissue and fecal, etiological have clarified role as pro-carcinogenic bacterium various stages CRC. In this review, we summarize biological characteristics epidemiological associations between CRC, then highlight mechanisms by which participates progression, metastasis, chemoresistance affecting cells or regulating microenvironment (TME). We also discuss research gap field give our perspective for future studies. These findings will pave way manipulating to deal future.

Language: Английский

Citations

87
Integrated approaches for precision oncology in colorectal cancer: The more you know, the better DOI
Pietro Andrei,

Paolo Battuello,

Gaia Grasso

et al.

Seminars in Cancer Biology, Journal Year: 2021, Volume and Issue: 84, P. 199 - 213

Published: April 13, 2021

Language: Английский

Citations

74
Gut Microbiota-Derived Metabolites in Colorectal Cancer: The Bad and the Challenges DOI Creative Commons
Wanru Zhang,

Yaping An,

Xiali Qin

et al.

Frontiers in Oncology, Journal Year: 2021, Volume and Issue: 11

Published: Oct. 18, 2021

Accumulating evidence from studies in humans and animal models has elucidated that gut microbiota, acting as a complex ecosystem, contributes critically to colorectal cancer (CRC). The potential mechanisms often reported emphasize the vital role of carcinogenic activities specific pathogens, but fact, series metabolites produced exogenous dietary substrates or endogenous host compounds occupy decisive position similarly. Detrimental microbiota-derived such trimethylamine-N-oxide, secondary bile acids, hydrogen sulfide N-nitroso could reconstruct ecological composition metabolic activity intestinal microorganisms formulate microenvironment opens susceptibility stimuli. They are implicated occurrence, progression metastasis CRC through different mechanisms, including inducing inflammation DNA damage, activating tumorigenic signaling pathways regulating tumor immunity. In this review, we mainly summarized intimate relationship between detrimental CRC, updated current knowledge about pathogenesis. Then, multiple interventions targeting these for management were reviewed, diet modulation, probiotics/prebiotics, fecal microbiota transplantation, well more precise measures engineered bacteria, phage therapy chemopreventive drugs. A better understanding interplay microbial would hold great promise against CRC.

Language: Английский

Citations

74
Role of Gut Microbiota and Probiotics in Colorectal Cancer: Onset and Progression DOI Creative Commons
Edgar Torres-Maravilla, Anne-Sophie Boucard, Amir Hossein Mohseni

et al.

Microorganisms, Journal Year: 2021, Volume and Issue: 9(5), P. 1021 - 1021

Published: May 10, 2021

The gut microbiota plays an important role in maintaining homeostasis the human body, and disruption of these communities can lead to compromised host health onset disease. Current research on probiotics is quite promising and, particular, microorganisms have demonstrated their potential for use as adjuvants treatment colorectal cancer. This review addresses possible applications probiotics, postbiotics, synbiotics, next-generation cancer research.

Language: Английский

Citations

65