Soil microbiomes and one health

Nature Reviews Microbiology, Journal Year: 2022, Volume and Issue: 21(1), P. 6 - 20

Published: Aug. 23, 2022

Language: Английский

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Antibiotic Resistance: One Health One World Outlook

Frontiers in Cellular and Infection Microbiology, Journal Year: 2021, Volume and Issue: 11

Published: Nov. 25, 2021

Antibiotic resistance (ABR) is a growing public health concern worldwide, and it now regarded as critical One Health issue. Health's interconnected domains contribute to the emergence, evolution, spread of antibiotic-resistant microorganisms on local global scale, which significant risk factor for health. The persistence resistant microbial species, association determinants at human-animal-environment interface can alter genomes, resulting in superbugs various niches. ABR motivated by well-established link between three domains: human, animal, environmental As result, addressing through approach makes sense. Several countries have implemented national action plans based combat microbes, following Tripartite's Commitment Food Agriculture Organization (FAO)-World Animal (OIE)-World (WHO) guidelines. has been identified concern, efforts are being made mitigate this threat. To summarize, interdisciplinary unified approaches principles required limit dissemination cycle, raise awareness education about antibiotic use, promote policy, advocacy, antimicrobial stewardship.

Language: Английский

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COVID-19 - Knowledge, Attitude and Practice among Medical and Non-Medical University Students in Jordan

Journal of Pure and Applied Microbiology, Journal Year: 2020, Volume and Issue: 14(1), P. 17 - 24

Published: March 31, 2020

The World Health Organization declared COVID-19 as a pandemic on the 11 th of March 2020.Since then, many efforts are being carried out to contain virus.Knowledge and attitude people should be directed towards strict preventive practices in order halt spread virus.The aim current cross-sectional study is assess knowledge, practice university students from medical non-medical colleges Jordan using structured questionnaire involving total number 592 students.A positive response regarding overall knowledge about symptoms was observed more than 90% students.In practice, good nearly 99.7% agreed that hand washing necessary for prevention infection whereas 68.4% believed mask wearing would prevent infection.Around 6-7% considered virus stigma hence not visit hospital.Also, around 10% their religious beliefs body immunity might protect them infection.More dangerously, 20.6% 19.2% antibiotics smoking protective measure against respectively.Also, 96.8% do avoid shaking, 98.8% wash hands 93.3% use alcoholic rub, 95.8% cough or sneeze tissue dispose it waste bin, 51% will drink ginger with honey 42.7% eat garlic prevention.The main sources were social media, internet television.No significant difference noticed between non colleges.Thus, there need detailed measures awareness campaigns improve some critical aspects virus.

Language: Английский

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Origin of Antibiotics and Antibiotic Resistance, and Their Impacts on Drug Development: A Narrative Review

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(11), P. 1615 - 1615

Published: Nov. 15, 2023

Antibiotics have revolutionized medicine, saving countless lives since their discovery in the early 20th century. However, origin of antibiotics is now overshadowed by alarming rise antibiotic resistance. This global crisis stems from relentless adaptability microorganisms, driven misuse and overuse antibiotics. article explores subsequent emergence It delves into mechanisms employed bacteria to develop resistance, highlighting dire consequences drug including compromised patient care, increased mortality rates, escalating healthcare costs. The elucidates latest strategies against drug-resistant encompassing innovative approaches such as phage therapy, CRISPR-Cas9 technology, exploration natural compounds. Moreover, it examines profound impact resistance on development, rendering pursuit new economically challenging. limitations challenges developing novel are discussed, along with hurdles regulatory process that hinder progress this critical field. Proposals for modifying facilitate development presented. withdrawal major pharmaceutical firms research examined, potential re-engage interest. also outlines initiatives overcome economic incentivize emphasizing international collaborations partnerships. Finally, sheds light government-led a specific focus Middle East. discusses proactive measures taken governments region, Saudi Arabia United Arab Emirates, combat threat. In face multifaceted approach imperative. provides valuable insights complex landscape challenges, collaborative efforts required ensure future where remain effective tools safeguarding public health.

Language: Английский

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Antimicrobial Resistance in Veterinary Medicine: An Overview

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(6), P. 1914 - 1914

Published: March 11, 2020

Antimicrobial resistance (AMR) represents one of the most important human- and animal health-threatening issues worldwide. Bacterial capability to face antimicrobial compounds is an ancient feature, enabling bacterial survival over time dynamic surrounding. Moreover, bacteria make use their evolutionary machinery adapt selective pressure exerted by antibiotic treatments, resulting in reduced efficacy therapeutic intervention against human infections. The mechanisms responsible for both innate acquired AMR are thoroughly investigated. Commonly, traits included mobilizable genetic elements homogeneous diffusion pool between ecosystems diverse sectors, such as medicine, veterinary environment. Thus, a coordinated multisectoral approach, One-Health, provides detailed comprehensive picture onset diffusion. Following general revision molecular AMR, present manuscript focuses on reviewing contribution medicine overall issue AMR. main sources amenable described, driving attention towards indissoluble cross-talk existing sectors cumulative cooperation this warning phenomenon.

Language: Английский

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A Systematic Review of Plants With Antibacterial Activities: A Taxonomic and Phylogenetic Perspective

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 11

Published: Jan. 8, 2021

Background: Antimicrobial resistance represents a serious threat to human health across the globe. The cost of bringing new antibiotic from discovery market is high and return on investment low. Furthermore, development antibiotics has slowed dramatically since 1950s’ golden age discovery. Plants produce variety bioactive secondary metabolites that could be used fuel future pipeline. While many studies have focused specific aspects plants plant natural products with antibacterial properties, comprehensive review potential never before been attempted. Objectives: This systematic aims evaluate reports significant activities. Methods: Following PRISMA model, we searched three electronic databases: Web Science, PubMed SciFinder by using keywords: “plant,” “antibacterial,” “inhibitory concentration.” Results: We identified total 6,083 articles published between 1946 2019 then reviewed 66% these (4,024) focusing 2012 2019. A rigorous selection process was implemented clear inclusion exclusion criteria, yielding data 958 species derived 483 scientific articles. Antibacterial activity found in 51 79 vascular orders throughout phylogenetic tree. Most are reported within eudicots, bulk being asterids. not prominent monocotyledons. Phylogenetic distribution strongly supports concept chemical evolution clades, especially more eudicot families. Lamiaceae, Fabaceae Asteraceae were most represented families, while Cinnamomum verum , Rosmarinus vulgaris Thymus studied species. South Africa site collection. Crude extraction methanol type leaves main tissue investigated. Finally, Staphylococcus aureus targeted pathogenic bacteria studies. closely examine 70 medicinal 15 families literature. Conclusion: depicts current state knowledge regarding antibacterials provides powerful recommendations for research directions.

Language: Английский

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Gut microbiota-derived short chain fatty acids are potential mediators in gut inflammation

Animal nutrition, Journal Year: 2021, Volume and Issue: 8, P. 350 - 360

Published: Dec. 29, 2021

Gut inflammation is a challenging concern in humans and animals, which disturbs normal growth leads to severe bowel diseases. Short chain fatty acids (SCFA) are the gut microbiota metabolites produced from fermentation of non-digestible carbohydrates, have been reported modulate inflammation. SCFA implicated as potential therapeutic bioactive molecules for inflammatory diseases, could be an alternative antibiotic promoters (AGP). In this review, existing knowledge about types SCFA, related microbes producing roles maintaining homeostasis, how summarized. The application treatment disease (IBD) also highlighted.

Language: Английский

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Manure as a Potential Hotspot for Antibiotic Resistance Dissemination by Horizontal Gene Transfer Events

Veterinary Sciences, Journal Year: 2020, Volume and Issue: 7(3), P. 110 - 110

Published: Aug. 13, 2020

The increasing demand for animal-derived foods has led to intensive and large-scale livestock production with the consequent formation of large amounts manure. Livestock manure is widely used in agricultural practices as soil fertilizer worldwide. However, several antibiotic residues, resistance genes (ARGs) antibiotic-resistant bacteria are frequently detected manure-amended soils. This review explores role persistence dissemination ARGs environment, analyzes procedures decrease antimicrobial potential impact application public health. We highlight that shows unique features a hotspot gene by horizontal transfer events: richness nutrients, high abundance diversity populations residues may exert selective pressure on trigger mobilization; reduction methodologies able reduce concentrations some, but not all, antimicrobials microorganisms. Conjugation events often seen even after composting. Antibiotic considered growing threat human, animal environmental Therefore, it crucial amount load resistant end up soil.

Language: Английский

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Antimicrobial Resistance in the Context of the Sustainable Development Goals: A Brief Review

European Journal of Investigation in Health Psychology and Education, Journal Year: 2021, Volume and Issue: 11(1), P. 71 - 82

Published: Jan. 19, 2021

The reduction in infectious disease morbidity and mortality may be attributed to a variety of factors; however, improved sanitation public health, the introduction vaccines antibiotics are among most significant. development antimicrobial resistance (AMR) bacterial pathogens is an expected consequence evolutionary adaptation these noxious agents widespread use drugs has significantly sped up this process. Infections caused by multidrug resistant directly associated with worse clinical outcomes, longer hospital stays, excess affected patients increasing burden costs on healthcare infrastructure. Sustainable Development Goals (SDGs) were published 2015 United Nations serve as global blueprint for better, more equitable, sustainable life our planet. SDGs contextualize AMR health societal issue; addition, continuing emergence limit attainment many SDGs. aim mini-review provide insight interface between problem drug bacteria.

Language: Английский

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Antibiotic Discovery and Resistance: The Chase and the Race

Antibiotics, Journal Year: 2022, Volume and Issue: 11(2), P. 182 - 182

Published: Jan. 30, 2022

The history of antimicrobial resistance (AMR) evolution and the diversity environmental resistome indicate that AMR is an ancient natural phenomenon. Acquired a public health concern influenced by anthropogenic use antibiotics, leading to selection resistant genes. Data show spreading globally at different rates, outpacing all efforts mitigate this crisis. search for new antibiotic classes one key strategies in fight against AMR. Since 1980s, newly marketed antibiotics were either modifications or improvements known molecules. World Health Organization (WHO) describes current pipeline as bleak, warns about scarcity leads. A quantitative qualitative analysis pre-clinical clinical indicates few may reach market years, predominantly not those fit innovative requirements tackle challenging spread Diversity innovation are mainstays cope with rapid discovery development must address old novel antibiotics. Here, we review challenges describe leads mechanisms expected replenish pipeline, while maintaining promising possibility shift chase race between AMR, preserving effectiveness, meeting requirements.

Language: Английский

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