Public human microbiome data are dominated by highly developed countries

PLoS Biology, Journal Year: 2022, Volume and Issue: 20(2), P. e3001536 - e3001536

Published: Feb. 15, 2022

The importance of sampling from globally representative populations has been well established in human genomics. In microbiome research, however, we lack a full understanding the global distribution research studies. This information is crucial to better understand patterns microbiome-associated diseases and extend health benefits this all populations. Here, analyze country origin 444,829 samples that are available world's 3 largest genomic data repositories, including Sequence Read Archive (SRA). 2,592 studies 19 body sites, 220,017 gut microbiome. We show more than 71% with known come Europe, United States, Canada, 46.8% US alone, despite representing only 4.3% population. also find central southern Asia most underrepresented region: Countries such as India, Pakistan, Bangladesh account for quarter world population but make up 1.8% samples. These results demonstrate critical need ensure representation participants

Language: Английский

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What Shall We Do With a Sea of Plastics? A Systematic Literature Review on How to Pave the Road Toward a Global Comprehensive Plastic Governance Agreement

Frontiers in Marine Science, Journal Year: 2021, Volume and Issue: 8

Published: Nov. 30, 2021

In February 2022, the United Nations Environmental Assembly (UNEA) is expected to mandate negotiations for a legally binding plastic agreement. preparations such discussions, it important understand academic research behind what global treaty on will require succeed. Therefore, systematic literature review was conducted 64 peer-reviewed articles published before July 4 th , 2021, that focused governance and avenues mitigate our pollution crisis. Once reviewed, were organized into series of four main categories: (1) overview articles, (2) top-down solutions, (3) bottom-up finally (4) as solution. The analysis these enabled an overarching discussion suggested required creation plastics First, researchers argued previous characterized by optimist perspective, i.e., view problem-solving mechanism. Second, field could make headway engaging in further empirical investigation current solutions at national level, especially developing nations. end we found agreement feasible if allows multi-stakeholder involving industry, governance, stakeholders, citizens.

Language: Английский

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Exiting the Anthropocene: Achieving personal and planetary health in the 21st century

Allergy, Journal Year: 2022, Volume and Issue: 77(12), P. 3498 - 3512

Published: June 24, 2022

Planetary health provides a perspective of ecological interdependence that connects the and vitality individuals, communities, Earth's natural systems. It includes social, political, economic ecosystems influence both individuals whole societies. In an era interconnected grand challenges threatening all systems at scales, planetary framework for cross-sectoral collaboration unified approaches to solutions. The field allergy is forefront these efforts. Allergic conditions are sentinel measure environmental impact on human in early life-illuminating how changes affect immune development predispose wider range inflammatory noncommunicable diseases (NCDs). This shows adverse macroscale ecology Anthropocene penetrates molecular level personal microscale ecology, including microbial foundations ecosystems. basis more integrated efforts address widespread degradation effects maladaptive urbanization, food systems, lifestyle behaviors, socioeconomic disadvantage. Nature-based solutions improve nature-relatedness crucial restoring symbiosis, balance, mutualism every sense, recognizing choices collective structural actions needed tandem. Ultimately, meaningful will depend placing greater emphasis psychological cultural dimensions such as mindfulness, values, moral wisdom ensure sustainable resilient future.

Language: Английский

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Human microbiome variation associated with race and ethnicity emerges as early as 3 months of age

PLoS Biology, Journal Year: 2023, Volume and Issue: 21(8), P. e3002230 - e3002230

Published: Aug. 17, 2023

Human microbiome variation is linked to the incidence, prevalence, and mortality of many diseases associates with race ethnicity in United States. However, age at which variability emerges between these groups remains a central gap knowledge. Here, we identify that gut associated arises after 3 months persists through childhood. One-third bacterial taxa vary across caregiver-identified racial categories children are reported also adults. Machine learning modeling childhood microbiomes from 8 cohort studies (2,756 samples 729 children) distinguishes ethnic 87% accuracy. Importantly, predictive genera among top 30 most important when used predict adult self-identified ethnicity. Our results highlight critical developmental window or shortly social environmental factors drive ethnicity-associated may contribute health disparities.

Language: Английский

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The indoors microbiome and human health

Nature Reviews Microbiology, Journal Year: 2024, Volume and Issue: 22(12), P. 742 - 755

Published: July 19, 2024

Language: Английский

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Socioecological justice in urban street greenery based on green view index-A case study within the Fuzhou Third Ring Road

Urban forestry & urban greening, Journal Year: 2024, Volume and Issue: 95, P. 128313 - 128313

Published: March 26, 2024

Language: Английский

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Chasing Ghosts: Race, Racism, and the Future of Microbiome Research

mSystems, Journal Year: 2021, Volume and Issue: 6(5)

Published: Oct. 12, 2021

In this article, we argue that a careful examination of human microbiome science's relationship with race and racism is necessary to foster equitable social ecological relations in the field. We point origins evolution problematic use literature by demonstrating increased usage both explicitly implicitly beyond sciences. demonstrate how these uses limit future rigorous just research. conclude an outline alternative actionable ways build more effective, antiracist science.

Language: Английский

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Twenty Important Research Questions in Microbial Exposure and Social Equity

mSystems, Journal Year: 2022, Volume and Issue: 7(1)

Published: Jan. 4, 2022

Social and political policy, human activities, environmental change affect the ways in which microbial communities assemble interact with people. These factors determine how different social groups are exposed to beneficial and/or harmful microorganisms, meaning exposure has an important socioecological justice context. Therefore, greater consideration of equity research, planning, policy is imperative. Here, we identify 20 research questions considered fundamentally promoting equitable along safeguarding resilient societies ecosystems. The identified span seven broad themes, including following: (i) sociocultural interactions; (ii) Indigenous community health well-being; (iii) humans, urban ecosystems, processes; (iv) psychology mental health; (v) microbiomes infectious diseases; (vi) food security; (vii) microbiome-related outreach. Our goal was summarize this growing field stimulate impactful avenues while providing focus for funders policymakers.

Language: Английский

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Maternal and food microbial sources shape the infant microbiome of a rural Ethiopian population

Current Biology, Journal Year: 2023, Volume and Issue: 33(10), P. 1939 - 1950.e4

Published: April 27, 2023

The human microbiome seeding starts at birth, when pioneer microbes are acquired mainly from the mother. Mode of delivery, antibiotic prophylaxis, and feeding method have been studied as modulators mother-to-infant transmission, but other key influencing factors like modern westernized lifestyles with high hygienization, high-calorie diets, urban settings, compared non-westernized not investigated yet. In this study, we explored mother-infant sharing characterized uncharacterized members via strain-resolved metagenomics in a cohort Ethiopian mothers infants, them four cohorts different lifestyles. newborns' microbiomes composition overlapped during first months life more than later life, likely reflecting similar initial breast-milk-based diets. infants shared smaller fraction their did most populations, despite showing higher diversity, species represented substantial those cohort. Moreover, identified belonging to Selenomonadaceae Prevotellaceae families specifically present only cohort, showed that locally produced fermented food, injera, can contribute diversity observed infants' gut bacteria part through food consumption. Taken together, these findings highlight fact lifestyle impact differences diet, drug consumption, environmental also its effect on strain-sharing patterns.

Language: Английский

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Can societal and ethical implications of precision microbiome engineering be applied to the built environment? A systematic review of the literature

Environment Systems & Decisions, Journal Year: 2024, Volume and Issue: 44(2), P. 215 - 238

Published: Feb. 24, 2024

Abstract The goal of engineering the microbiome built environment is to create places and spaces that are better for human health. Like other emerging technologies, may bring considerable benefits but there has been a lack exploration on its societal implication how engineer in an ethical way. To date, this topic area also not pulled together into singular study any systematic review or analysis. This fills gap by providing first implications microbiomes application knowledge environment. organize guide our analysis, we invoked four major principles (individual good/non-maleficence, collective good/beneficence, autonomy, justice) as framework characterizing categorizing 15 distinct themes emerged from literature. We argue these different can be used explain predict social if addressed adequately help improve public health field further develops at global scales.

Language: Английский

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