A systematic framework for understanding the microbiome in human health and disease: from basic principles to clinical translation

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Sept. 23, 2024

Language: Английский

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Microbiome-Driven Therapeutics: From Gut Health to Precision Medicine

Gastrointestinal Disorders, Journal Year: 2025, Volume and Issue: 7(1), P. 7 - 7

Published: Jan. 15, 2025

The human microbiome, a complex ecosystem of microorganisms residing in and on the body, plays pivotal role regulation wide range physiological processes, including digestion, immune responses, metabolic functions. In recent years, rapidly growing field microbiome-driven therapeutics has garnered significant attention owing to its potential revolutionize healthcare. This review explores evolving landscape microbiome-based therapies, with particular focus gut microbiome implications for both health precision medicine. We highlight advances understanding how microbial communities influence disease pathogenesis treatment outcomes, spanning conditions such as inflammatory bowel (IBD), disorders, neurological diseases, even cancer. article also discusses emerging therapeutic strategies, probiotics, prebiotics, fecal microbiota transplantation (FMT), microbial-based drugs, well challenges associated their clinical implementation. Additionally, we examined integration profiling metagenomic data is advancing medicine, paving way personalized effective treatments. serves comprehensive resource that synthesizes current knowledge, identifies key gaps research, offers insights into future direction therapeutics, thus providing valuable framework clinicians, researchers, policymakers seeking harness microbiomes advance healthcare solutions.

Language: Английский

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Exiting the Anthropocene: Achieving personal and planetary health in the 21st century

Allergy, Journal Year: 2022, Volume and Issue: 77(12), P. 3498 - 3512

Published: June 24, 2022

Planetary health provides a perspective of ecological interdependence that connects the and vitality individuals, communities, Earth's natural systems. It includes social, political, economic ecosystems influence both individuals whole societies. In an era interconnected grand challenges threatening all systems at scales, planetary framework for cross-sectoral collaboration unified approaches to solutions. The field allergy is forefront these efforts. Allergic conditions are sentinel measure environmental impact on human in early life-illuminating how changes affect immune development predispose wider range inflammatory noncommunicable diseases (NCDs). This shows adverse macroscale ecology Anthropocene penetrates molecular level personal microscale ecology, including microbial foundations ecosystems. basis more integrated efforts address widespread degradation effects maladaptive urbanization, food systems, lifestyle behaviors, socioeconomic disadvantage. Nature-based solutions improve nature-relatedness crucial restoring symbiosis, balance, mutualism every sense, recognizing choices collective structural actions needed tandem. Ultimately, meaningful will depend placing greater emphasis psychological cultural dimensions such as mindfulness, values, moral wisdom ensure sustainable resilient future.

Language: Английский

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Neighborhood socioeconomic status is associated with low diversity gut microbiomes and multi-drug resistant microorganism colonization

npj Biofilms and Microbiomes, Journal Year: 2023, Volume and Issue: 9(1)

Published: Aug. 28, 2023

Abstract Social disparities continue to limit universal access health care, directly impacting both lifespan and quality of life. Concomitantly, the gut microbiome has been associated with downstream outcomes including global rise in antibiotic resistance. However, limited evidence exists examining socioeconomic status (SES) associations composition. To address this, we collected information on community-level SES, microbiota, other individual cofactors colonization by multidrug-resistant organisms (MDROs) an adult cohort from Wisconsin, USA. We found association between SES microbial composition that is mediated food insecurity. Additionally, observed a higher prevalence MDROs isolated individuals low diversity microbiomes neighborhood SES. Our integrated population-based study considers how interplay several social economic factors combine influence while providing framework for developing future interventions help mitigate gap.

Language: Английский

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Opportunities and challenges for microbiomics in ecosystem restoration

Trends in Ecology & Evolution, Journal Year: 2023, Volume and Issue: 38(12), P. 1189 - 1202

Published: Aug. 28, 2023

Language: Английский

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Nature Connection: Providing a Pathway from Personal to Planetary Health

Challenges, Journal Year: 2023, Volume and Issue: 14(1), P. 16 - 16

Published: March 5, 2023

The vast and growing challenges for human health all life on Earth require urgent deep structural changes to the way in which we live. Broken relationships with nature are at core of both modern crisis erosion planetary health. A declining connection has been implicated exploitative attitudes that underpin degradation physical social environments almost aspects personal physical, mental, spiritual It is increasingly clear entwined biodiversity loss, climate change, cannot be addressed without addressing selfishness, greed, apathy, value systems created these global problems. Calls a cultural transformation recognize “inner” development important necessary meaningful “outward” transitions shared purpose wiser, more sustainable societies. Many emotional assets appear facilitated by nature, also strongly associated community cohesion, prosocial attitudes, pro-environmental actions. Restoring may therefore provide critical common pathway promote wellbeing individuals communities as well environmental responsibility. In this paper, summarize reflect discussions Nova Network respect nature-based solutions pathways mutualistic mindset. These spanned biological psychological interactions nature—including microbes influence emotional, behavioral We consider ways stronger “inner assets” support “outward actions”

Language: Английский

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Indigenous Knowledge and the Microbiome—Bridging the Disconnect between Colonized Places, Peoples, and the Unseen Influences That Shape Our Health and Well-Being

mSystems, Journal Year: 2023, Volume and Issue: 8(1)

Published: Jan. 25, 2023

Indigenous Peoples have a rich and long-standing connection with the environments that they descend from-a has informed deep multifaceted understanding of relationship between human well-being environment. Through cultural narratives practices, much this knowledge endured despite ongoing effects colonization had on many peoples across world. These based observation, experimentation, practical application over generations, potential to make compelling contributions our environmental microbiome its health. Furthermore, inclusion perspectives regarding opens pathways those who rarely engage field learnings. Within scientific community, not always been acknowledged as valid are often seen myth or lacking rigor. Thus, paper aims explore an perspective unseen influence health by framing importance natural environment, leadership, future research directions can contribute domain. Although in article reflects experiences, worldviews, two New Zealand Māori authors, it is hoped concepts discussed relate peoples, non-Indigenous advocates, globally.

Language: Английский

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Maternal and food microbial sources shape the infant microbiome of a rural Ethiopian population

Current Biology, Journal Year: 2023, Volume and Issue: 33(10), P. 1939 - 1950.e4

Published: April 27, 2023

The human microbiome seeding starts at birth, when pioneer microbes are acquired mainly from the mother. Mode of delivery, antibiotic prophylaxis, and feeding method have been studied as modulators mother-to-infant transmission, but other key influencing factors like modern westernized lifestyles with high hygienization, high-calorie diets, urban settings, compared non-westernized not investigated yet. In this study, we explored mother-infant sharing characterized uncharacterized members via strain-resolved metagenomics in a cohort Ethiopian mothers infants, them four cohorts different lifestyles. newborns' microbiomes composition overlapped during first months life more than later life, likely reflecting similar initial breast-milk-based diets. infants shared smaller fraction their did most populations, despite showing higher diversity, species represented substantial those cohort. Moreover, identified belonging to Selenomonadaceae Prevotellaceae families specifically present only cohort, showed that locally produced fermented food, injera, can contribute diversity observed infants' gut bacteria part through food consumption. Taken together, these findings highlight fact lifestyle impact differences diet, drug consumption, environmental also its effect on strain-sharing patterns.

Language: Английский

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Can societal and ethical implications of precision microbiome engineering be applied to the built environment? A systematic review of the literature

Environment Systems & Decisions, Journal Year: 2024, Volume and Issue: 44(2), P. 215 - 238

Published: Feb. 24, 2024

Abstract The goal of engineering the microbiome built environment is to create places and spaces that are better for human health. Like other emerging technologies, may bring considerable benefits but there has been a lack exploration on its societal implication how engineer in an ethical way. To date, this topic area also not pulled together into singular study any systematic review or analysis. This fills gap by providing first implications microbiomes application knowledge environment. organize guide our analysis, we invoked four major principles (individual good/non-maleficence, collective good/beneficence, autonomy, justice) as framework characterizing categorizing 15 distinct themes emerged from literature. We argue these different can be used explain predict social if addressed adequately help improve public health field further develops at global scales.

Language: Английский

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On the values of microbes: An ethical investigation of relational values associated with the microbial world

People and Nature, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Abstract Current microbiome research has revealed that microbes support nearly all life on Earth, are essential for food production, affect human physical health and psychological well‐being maintain ecological processes. Consequently, there many reasons to value them, especially in times of crises the pending end so‐called antibiotic era. However, a theoretical analysis existing values regarding microorganisms is still missing environmental ethics humanities. In this paper, we provide such an ethical analysis. Therefore, briefly introduce different types (Section 2.1) then discuss what exist with respect microbial world, focusing various instrumental relational 2.2). The examine direct use value, function scientific transformative religious/spiritual existence aesthetic value. To latter, example visual poetic art humans co‐create illustrate encompasses. Concluding, Section 3, argue why could be used as cornerstone establish distinct human–microbe relations do justice complexity our entanglement microbes. Read free Plain Language Summary article Journal blog.

Language: Английский

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