The relationship between gut and nasopharyngeal microbiome composition can predict the severity of COVID-19 DOI Creative Commons

Benita Martín-Castaño,

Patricia Diez‐Echave, Jorge García-García

et al.

eLife, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 18, 2025

Coronavirus disease 2019 (COVID-19) is a respiratory illness caused by severe acute syndrome coronavirus 2 (SARS-CoV-2) that displays great variability in clinical phenotype. Many factors have been described to be correlated with its severity, and microbiota could play key role the infection, progression, outcome of disease. SARS-CoV-2 infection has associated nasopharyngeal gut dysbiosis higher abundance opportunistic pathogens. To identify new prognostic markers for disease, multicentre prospective observational cohort study was carried out COVID-19 patients divided into three cohorts based on symptomatology: mild (n = 24), moderate 51), severe/critical 31). Faecal samples were taken, analysed. Linear discriminant analysis identified Mycoplasma salivarium , Prevotella dentalis Haemophilus parainfluenzae as biomarkers microbiota, while bivia timonensis defined faecal microbiota. Additionally, connection between identified, significant ratio P. (faeces) M. (nasopharyngeal) abundances found critically ill patients. This serve novel tool identifying cases.

Language: Английский

Gut microbiota in COVID-19: key microbial changes, potential mechanisms and clinical applications DOI Open Access
Fen Zhang, Raphaela Iris Lau, Qin Liu

et al.

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2022, Volume and Issue: 20(5), P. 323 - 337

Published: Oct. 21, 2022

Language: Английский

Citations

193
The emerging role of the gut microbiota and its application in inflammatory bowel disease DOI Open Access
Wang Xiu, Jianhua Peng,

Peipei Cai

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 179, P. 117302 - 117302

Published: Aug. 19, 2024

Inflammatory bowel disease (IBD), including Crohn's and ulcerative colitis, is a complex disorder with an unknown cause. However, the dysbiosis of gut microbiome has been found to play role in IBD etiology, exacerbated immune responses defective intestinal barrier integrity. The can also be potential biomarker for several diseases, IBD. Currently, conventional treatments targeting pro-inflammatory cytokines pathways IBD-associated do not yield effective results. Other therapies that directly target dysbiotic outcomes are emerging. We review health its as diagnostic, prognostic, therapeutic This explores emerging advancements microbiome-associated alterations IBD, such nanoparticle or encapsulation delivery, fecal microbiota transplantation, nutritional therapies, microbiome/probiotic engineering, phage therapy, mesenchymal stem cells (MSCs), proteins, herbal formulas.

Language: Английский

Citations

18
Gastrointestinal symptoms in COVID-19: the long and the short of it DOI
Daniel E. Freedberg, Lin Chang

Current Opinion in Gastroenterology, Journal Year: 2022, Volume and Issue: unknown

Published: Sept. 9, 2022

A large and growing number of patients have persistent gastrointestinal symptoms that they attribute to COVID-19. SARS-CoV-2, the virus causes COVID-19, replicates within gut acute COVID-19 is associated with alteration microbiome. This article reviews recent observational data related in 'long COVID' discusses pathophysiologic mechanisms might explain post-COVID symptoms.Gastrointestinal are present half persist 6 months after 10-25% patients, rated as most bothersome symptom 11% all patients. These include heartburn, constipation, diarrhoea abdominal pain decline prevalence passage time. Long COVID mental health (anxiety depression) predate also concurrent, recovery from The cause long unknown hypotheses SARS-CoV-2 itself, which infects tract; can be accompanied by microbiome changes, a profound systemic inflammatory response critical illness; and/or effects pandemic stress on function perception, may unrelated either or COVID-19.New, commonly reported pathophysiology these but likely multifactorial.

Language: Английский

Citations

44
Immunomodulatory fecal metabolites are associated with mortality in COVID-19 patients with respiratory failure DOI Creative Commons

M.R. Stutz,

Nicholas P. Dylla, Steven D. Pearson

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Nov. 3, 2022

Abstract Respiratory failure and mortality from COVID-19 result virus- inflammation-induced lung tissue damage. The intestinal microbiome associated metabolites are implicated in immune responses to respiratory viral infections, however their impact on progression of severe remains unclear. We prospectively enrolled 71 patients with critical illness, collected fecal specimens within 3 days medical intensive care unit admission, defined compositions by shotgun metagenomic sequencing, quantified microbiota-derived (NCT #04552834). Of the patients, 39 survived 32 died. Mortality was increased representation Proteobacteria microbiota decreased concentrations secondary bile acids desaminotyrosine (DAT). A metabolic profile (MMP) that accounts for independently leading mechanical ventilation. Our findings demonstrate composition metabolite can predict trajectory function death SARS-Cov-2 infection suggest gut-lung axis plays an important role recovery COVID-19.

Language: Английский

Citations

42
The gut-microbiota-brain axis in a Spanish population in the aftermath of the COVID-19 pandemic: microbiota composition linked to anxiety, trauma, and depression profiles DOI Creative Commons
Stefanie Malan‐Müller, Mireia Valles‐Colomer, Tomás Palomo

et al.

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(1)

Published: Jan. 18, 2023

The prevalence of anxiety and depression soared following the COVID-19 pandemic. To effectively treat these conditions, a comprehensive understanding all etiological factors is needed. This study investigated fecal microbial features associated with mental health outcomes (symptoms anxiety, depression, or posttraumatic stress disorder (PTSD)) in Spanish cohort aftermath Microbial communities from stool samples were profiled 198 individuals who completed validated, self-report questionnaires. 16S ribosomal RNA gene V3-4 amplicon sequencing was performed. diversity community structure analyzed, together relative taxonomic abundance. In our N=198, 17.17% reported depressive symptoms, 37.37% state 40.90% trait 8.08% PTSD high levels comorbidity. Individuals had lower Simpson's diversity. Fusicatenibacter saccharivorans reduced comorbid + whilst an expansion Proteobacteria depletion Synergistetes phyla noted symptoms. abundance Anaerostipes positively correlated childhood trauma, higher Turicibacter sanguinis Lentisphaerae found experienced life-threatening traumas. infection vaccination influenced overall composition distinct profiles. These findings will help lay foundation for future studies to identify role players symptoms provide therapeutic targets improve outcomes.

Language: Английский

Citations

34
High body temperature increases gut microbiota-dependent host resistance to influenza A virus and SARS-CoV-2 infection DOI Creative Commons

Minami Nagai,

Miyu Moriyama, Chiharu Ishii

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: June 30, 2023

Abstract Fever is a common symptom of influenza and coronavirus disease 2019 (COVID-19), yet its physiological role in host resistance to viral infection remains less clear. Here, we demonstrate that exposure mice the high ambient temperature 36 °C increases pathogens including virus severe acute respiratory syndrome 2 (SARS-CoV-2). High heat-exposed increase basal body over 38 enable more bile acids production gut microbiota-dependent manner. The microbiota-derived deoxycholic acid (DCA) plasma membrane-bound receptor Takeda G-protein-coupled 5 (TGR5) signaling by suppressing replication neutrophil-dependent tissue damage. Furthermore, DCA nuclear farnesoid X (FXR) agonist protect Syrian hamsters from lethal SARS-CoV-2 infection. Moreover, certain are reduced COVID-19 patients who develop moderate I/II compared with minor severity illness group. These findings implicate mechanism which virus-induced fever

Language: Английский

Citations

34
The relationship between gut microbiota and COVID-19 progression: new insights into immunopathogenesis and treatment DOI Creative Commons
Man Wang, Yuan Zhang, Chunmei Li

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: May 2, 2023

The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2) has posed a global health crisis. Increasing evidence underlines the key role of competent immune responses in resisting SARS-CoV-2 infection and manifests disastrous consequence host dysregulation. Elucidating mechanisms responsible for deregulated immunity COVID-19 may provide theoretical basis further research on new treatment modalities. Gut microbiota comprises trillions microorganisms colonizing human gastrointestinal tract vital homeostasis gut-lung crosstalk. Particularly, can lead to disruption gut equilibrium, condition called dysbiosis. Due its regulatory effect immunity, recently received considerable attention field immunopathology. Imbalanced fuel progression through production bioactive metabolites, intestinal metabolism, enhancement cytokine storm, exaggeration inflammation, regulation adaptive other aspects. In this review, we an overview alterations patients, their effects individuals’ susceptibility viral progression. Moreover, summarize currently available data critical bidirectional between microbes SARS-CoV-2-induced pathology, highlight immunomodulatory contributing pathogenesis. addition, discuss therapeutic benefits future perspectives microbiota-targeted interventions including faecal transplantation (FMT), bacteriotherapy traditional Chinese medicine (TCM) treatment.

Language: Английский

Citations

31
Emerging role of the gut microbiome in post-infectious irritable bowel syndrome: A literature review DOI Creative Commons
Vasile Valeriu Lupu, Cristina Mihaela Ghiciuc, Gabriela Ștefănescu

et al.

World Journal of Gastroenterology, Journal Year: 2023, Volume and Issue: 29(21), P. 3241 - 3256

Published: May 30, 2023

Post-infectious irritable bowel syndrome (PI-IBS) is a particular type of IBS, with symptom onset after an acute episode infectious gastroenteritis. Despite disease resolution and clearance the inciting pathogen agent, 10% patients will develop PI-IBS. In susceptible individuals, exposure to pathogenic organisms leads marked shift in gut microbiota prolonged changes host-microbiota interactions. These can affect gut-brain axis visceral sensitivity, disrupting intestinal barrier, altering neuromuscular function, triggering persistent low inflammation, sustaining IBS symptoms. There no specific treatment strategy for Different drug classes be used treat PI-IBS similar general, guided by their clinical This review summarizes current evidence microbial dysbiosis analyzes available data regarding role microbiome mediating central peripheral dysfunctions that lead It also discusses state on therapies targeting management The results modulation strategies relieving symptomatology are encouraging. Several studies animal models reported promising results. However, published describe efficacy safety targeted therapy scarce. Future research required.

Language: Английский

Citations

29
The causal links between gut microbiota and COVID‐19: A Mendelian randomization study DOI
Jukun Song, Yadong Wu,

Xinhai Yin

et al.

Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(5)

Published: May 1, 2023

Several studies have shown a possible correlation between gut microbiota and COVID-19. However, the cause-and-effect relationship two has not been investigated. We conducted two-sample Mendelian randomization study (MR) using publicly available GWAS data. Inverse variance weighted (IVW) analysis was main MR technique supplemented with other sensitivity analyses. Forty-two bacterial genera were associated COVID-19 susceptibility, hospitalization, severity in IVW method. Among these microbiota, five (genus unknowngenus [id.1000005472], family unknownfamily [id.1000005471], genus Tyzzerella3, order MollicutesRF9.id.11579, phylum Actinobacteria) significantly hospitalization severity. Three (class Negativicutes, Selenomonadales, class while Negativicutes Selenomonadales) severity, susceptibility. Sensitivity did detect any heterogeneity horizontal pleiotropy. Our findings demonstrated that several microorganisms causally linked to COVID-19, improved our understanding of pathology.

Language: Английский

Citations

25
Short-Chain Fatty Acid (SCFA) as a Connecting Link between Microbiota and Gut-Lung Axis─A Potential Therapeutic Intervention to Improve Lung Health DOI Creative Commons
Anjali Verma, Tannu Bhagchandani, Ankita Rai

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 9(13), P. 14648 - 14671

Published: March 19, 2024

The microbiome is an integral part of the human gut, and it plays a crucial role in development immune system homeostasis. Apart from gut microbiome, airway microbial community also forms distinct microbiota. Furthermore, several studies indicate existence communication between their metabolites with lung airways, called "gut–lung axis". Perturbations microbiota composition, termed dysbiosis, can have acute chronic effects on pathophysiology diseases. Microbes stimulate various innate pathways, which modulate expression inflammatory genes pulmonary leukocytes. For instance, microbiota-derived such as short-chain fatty acids suppress inflammation through activation G protein-coupled receptors (free acid receptors) inhibit histone deacetylase, turn influences severity respiratory Thus, modulation composition probiotic/prebiotic usage fecal transplantation lead to alterations homeostasis immunity. resulting manipulation cells function key paves way for novel therapeutic strategies improving health individuals affected diseases including SARS-CoV-2. This review will shed light upon mechanistic aspect programming exploration relationship gut–lung highlight potential management

Language: Английский

Citations

14