Role of the Gut Microbiota in Osteoarthritis, Rheumatoid Arthritis, and Spondylarthritis: An Update on the Gut–Joint Axis

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3242 - 3242

Published: March 13, 2024

Dysregulation of the gut microbiota and their metabolites is involved in pathogenic process intestinal diseases, several pieces evidence within current literature have also highlighted a possible connection between unfolding inflammatory pathologies joints. This dysregulation defined as "gut-joint axis" based on joint-gut interaction. It widely recognized that produce variety compounds, including enzymes, short-chain fatty acids, metabolites. As consequence, these proinflammatory compounds bacteria produce, such lipopolysaccharide, move from "leaky gut" to bloodstream, thereby leading systemic inflammation which then reaches joints, with consequences osteoarthritis, rheumatoid arthritis, spondylarthritis. In this state-of-the-art research, authors describe connections dysbiosis Moreover, diagnostic tools, outcome measures, treatment options are elucidated. There accumulating proof suggesting play an important part not only immune-mediated, metabolic, neurological illnesses but According authors, future studies should concentrate developing innovative microbiota-targeted treatments effects joint pathology well organizing screening protocols predict onset disease dysbiosis.

Language: Английский

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Oral Administration of Bovine Milk-Derived Extracellular Vesicles Attenuates Cartilage Degeneration via Modulating Gut Microbiota in DMM-Induced Mice

Nutrients, Journal Year: 2023, Volume and Issue: 15(3), P. 747 - 747

Published: Feb. 1, 2023

Osteoarthritis (OA) is the most common joint disease primarily characterized by cartilage degeneration. Milk-derived extracellular vesicles (mEVs) were reported to inhibit catabolic and inflammatory processes in of OA patients. However, current therapies target advanced symptoms OA, it significant develop a novel strategy driving pathology. In this study, we investigated therapeutic potential mEVs alleviating vivo. The results revealed that ameliorated degeneration increasing hyaline thickness, decreasing histological Research Society International (OARSI) scores, enhancing matrix synthesis, reducing expression destructive enzymes destabilization medial meniscus (DMM) mice. addition, disturbed gut microbiota DMM mice was partially improved upon treatment with mEVs. It observed pro-inflammatory bacteria (Proteobacteria) reduced beneficial (Firmicutes, Ruminococcaceae, Akkermansiaceae) increased. could alleviate progression restoring homeostasis reshaping microbiota. These findings suggested might be dietary supplement for OA.

Language: Английский

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The Role of Genetics and Epigenetic Regulation in the Pathogenesis of Osteoarthritis

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(14), P. 11655 - 11655

Published: July 19, 2023

Osteoarthritis (OA) is progressive disease characterised by cartilage degradation, subchondral bone remodelling and inflammation of the synovium. The associated with obesity, mechanical load age. However, multiple pro-inflammatory immune mediators regulate expression metalloproteinases, which take part in degradation. Furthermore, genetic factors also contribute to OA susceptibility. Recent studies have highlighted that epigenetic mechanisms may OA-associated genes. This review aims present pathogenesis summarise current evidence regarding role genetics epigenetics this process.

Language: Английский

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Gut Phageome—An Insight into the Role and Impact of Gut Microbiome and Their Correlation with Mammal Health and Diseases

Microorganisms, Journal Year: 2023, Volume and Issue: 11(10), P. 2454 - 2454

Published: Sept. 29, 2023

The gut microbiota, including bacteria, archaea, fungi, and viruses, compose a diverse mammalian environment are highly associated with host health. Bacteriophages, the viruses that infect primary members of gastrointestinal virome, known as phageome. However, our knowledge regarding phageome remains poorly understood. In this review, critical role its correlation health were summarized. First, an overall profile phages across tract their dynamic roles in shaping surrounding microorganisms was elucidated. Further, impacts on fitness bacterial community highlighted, together influence diets composition. Additionally, new reports association diseases reviewed. Finally, comprehensive update advanced phage benchwork contributions phage-based therapy to prevent/treat provided. This study provides insights into impact phagenome environments closely related mammal diseases. findings provoke potential applications diagnosis clinical agricultural fields. Future research is needed uncover underlying mechanism phage–bacterial interactions explore maintenance via phage-regulated microbiota.

Language: Английский

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The Complex Interplay between the Gut Microbiome and Osteoarthritis: A Systematic Review on Potential Correlations and Therapeutic Approaches

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 25(1), P. 143 - 143

Published: Dec. 21, 2023

The objective of this review is to systematically analyze the potential correlation between gut microbiota and osteoarthritis (OA) as well evaluate feasibility microbiota-targeted therapies for treating OA. Studies conducted from October 2013 2023 were identified via a search on electronic databases such PubMed, Web Science, Scopus, following established PRISMA statement standards. Two reviewers independently screened, assessed, extracted relevant data, then they graded studies using ROBINS I tool non-randomized interventions SYRCLE’s risk-of-bias animal studies. A through 370 yielded 38 (24 preclinical 14 clinical) that included. In vivo research has predominantly concentrated modifying microenvironment, dietary supplements, probiotics, prebiotics modify OA status. Lactobacilli are most thoroughly examined with Lactobacillus acidophilus found effectively reduce cartilage damage, inflammatory factors, pain. Additionally, M5 inhibits development by preventing high-fat diet (HFD)-induced obesity protecting damage. Although there limited clinical studies, certain compositions intestinal may be associated onset progression OA, while others linked pain reduction in patients. Based evidence suggest could play significant role However, due scarcity exact mechanism linking remains unclear. Further necessary specific compositions, pathogens, their corresponding signaling pathways contribute This will help validate targeting

Language: Английский

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Diet influences knee osteoarthritis osteophyte formation via gut microbiota and serum metabolites

iScience, Journal Year: 2024, Volume and Issue: 27(6), P. 110111 - 110111

Published: May 24, 2024

Osteophyte formation, a key indicator of osteoarthritis (OA) severity, remains poorly understood in its relation to gut microbiota and metabolites knee (KOA). We conducted 16S rDNA sequencing untargeted metabolomics on fecal serum samples from 20 healthy volunteers, 80 KOA patients Guangdong, 100 Inner Mongolia, respectively. Through bioinformatics analysis, we identified 3 genera 5 associated with osteophyte formation. Blautia abundance negatively correlated meat, cheese, bean consumption. The dairy, beef, sugar, salt intake, yet positively age oil Higher levels the may contribute LTB4 PGD2 potentially serving as biomarkers. Mongolia exhibited lower reduced expression metabolites, possibly due cheese consumption habits, resulting less

Language: Английский

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Gut virome-wide association analysis identifies cross-population viral signatures for inflammatory bowel disease

Microbiome, Journal Year: 2024, Volume and Issue: 12(1)

Published: July 18, 2024

Abstract Background The gut virome has been implicated in inflammatory bowel disease (IBD), yet a full understanding of the IBD patients, especially across diverse geographic populations, is lacking. Results In this study, we conducted comprehensive virome-wide association study Chinese cohort 71 patients (15 with Crohn’s and 56 ulcerative colitis) 77 healthy controls via viral-like particle (VLP) bulk sequencing their feces. By utilizing an integrated virus catalog tailored to virome, revealed fundamental alterations patients. These characterized 139 differentially abundant viral signatures, including elevated phages predicted infect Escherichia , Klebsiella Enterococcus_B Streptococcus Veillonella species as well IBD-depleted targeting Prevotella Ruminococcus_E Bifidobacterium Blautia . Remarkably, these signatures demonstrated high consistency populations such those Europe USA, emphasizing significance broad relevance context. Furthermore, fecal transplantation experiments verified that colonization IBD-characterized viruses can modulate experimental colitis mouse models. Conclusions Building upon insights into identified potential biomarkers for prognosis therapy laying foundation further exploration viromes related conditions.

Language: Английский

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A population-scale analysis of 36 gut microbiome studies reveals universal species signatures for common diseases

npj Biofilms and Microbiomes, Journal Year: 2024, Volume and Issue: 10(1)

Published: Oct. 1, 2024

Language: Английский

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Specific gut microbiota and serum metabolite changes in patients with osteoarthritis

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 14, 2025

Introduction Recent research indicated a strong link between the gut microbiota and osteoarthritis. However, complex interplay microbiota, serum metabolites, progression of osteoarthritis in affected individuals remains largely unexplored. This study aimed to investigate characteristics metabolites patients with Methods Participants either healthy knees or were enrolled categorized into control (HC) (OA) groups. Fecal blood samples collected for 16S rRNA gene sequencing, metabolomic analysis via liquid chromatography–mass spectrometry (LC-MS), integrated evaluation. Results The results showed no significant variation richness diversity two abundance Bacteroides plebeius Faecalibacterium prausnitzii was reduced OA group, both which are known their potential as next-generation probiotics human health. Metabolomic that including pyrogallol 3-hydroxybutyrate (3HB), significantly lower group. These positively impact other diseases demonstrated good diagnostic performance distinguishing from controls. Correlation revealed positive correlation 3HB. Discussion highlighted specific metabolite profiles patients, suggesting changes bacteria derived closely tied progression. underscores modifiable elements therapeutic targets prevention.

Language: Английский

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Gut and Joint Microbiomes

Rheumatic Disease Clinics of North America, Journal Year: 2025, Volume and Issue: 51(2), P. 295 - 324

Published: March 6, 2025

Language: Английский

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