The Role of the Intestinal Flora and Its Derivatives in Neurocognitive Disorders: A Narrative Review from Surgical Perspective DOI Creative Commons
Jian Huang,

T Qin,

Yun Bo

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: July 10, 2024

Abstract Perioperative neurocognitive dysfunction is a significant concern for population health, impacting postoperative recovery and increasing the financial burden on patients. With an number of surgical procedures being performed, prevention management perioperative have garnered attention. While factors such as age, lifestyle, genetics, education are known to influence development cognitive dysfunction, recent research has highlighted role gut microbiota in neurological health. An increased abundance pro-inflammatory can trigger worsen neuroinflammation, neuronal cell damage, impaired cellular autophagy. Moreover, inflammation-promoting disrupt immune function, impair neuroautophagy, affect production circulation extracellular vesicles neurotransmitters. These collectively play onset advancement impairment. This narrative review delves into molecular mechanisms through which their derivatives contribute impairment, focusing impact anesthesia surgery, changes microbial populations, impairment associations. The study suggests that alterations various bacterial species metabolites pre- post-surgery may be linked Furthermore, potential probiotics or prebiotics addressing discussed, offering promising avenue investigating treatment disorders.

Language: Английский

The probiotic Lactobacillus plantarum alleviates colitis by modulating gut microflora to activate PPARγ and inhibit MAPKs/NF-κB DOI

Rongxin Zang,

Rui Zhou,

Yaodong Li

et al.

European Journal of Nutrition, Journal Year: 2024, Volume and Issue: 64(1)

Published: Nov. 28, 2024

Language: Английский

Citations

4
Incomplete human reference genomes can drive false sex biases and expose patient-identifying information in metagenomic data DOI Creative Commons
Caitlin Guccione, Lucas Patel, Yoshihiko Tomofuji

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 18, 2025

Abstract As next-generation sequencing technologies produce deeper genome coverages at lower costs, there is a critical need for reliable computational host DNA removal in metagenomic data. We find that insufficient filtration using prior human references can introduce false sex biases and inadvertently permit flow-through of host-specific during bioinformatic analyses, which could be exploited individual identification. To address these issues, we benchmark three methods varying throughput, with concomitant applications across low biomass samples such as skin high microbial datasets including fecal samples. are important obtaining accurate results (e.g., tissue, skin). Overall, demonstrate rigorous key component privacy-minded analyses patient microbiomes provide computationally efficient pipelines accomplishing this task on large-scale datasets.

Language: Английский

Citations

0
Changes in root-associated bacterial communities across growth stages of salt-tolerant and salt-sensitive rice grown in coastal saline-alkali soils DOI
Qing Li,

Jihui Jiang,

Haoyang Cheng

et al.

World Journal of Microbiology and Biotechnology, Journal Year: 2025, Volume and Issue: 41(3)

Published: Feb. 27, 2025

Language: Английский

Citations

0
Postoperative neurocognitive disorders in the elderly: how can we stop the harm? A literature review DOI Creative Commons
Ling Ma,

H Jasem,

Wen Gu

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 6, 2025

Postoperative neurocognitive disorders (PND) represent a significant challenge affecting patients undergoing surgical procedures, particularly in the elderly population. These can lead to profound impairments cognitive function, impacting memory, attention, and overall quality of life. Despite ongoing research efforts identify risk factors improve management strategies, PND remains underdiagnosed poorly understood, complicating postoperative recovery rehabilitation. This review aims explore recent advancement literature about PND, focusing on underlying mechanisms, factors, potential therapeutic approaches. We highlight advancements understanding neuroinflammation, it is implications for novel therapies prevent PND. By synthesizing latest research, we hope provide insights that could improved outcomes at foster shift towards more effective preventive measures such

Language: Английский

Citations

0
Stevia rebaudiana root polysaccharide modulates liver metabolism, bile acid, and gut microbiota improving HFD-induced NAFLD: Potential roles of ACSL1 and FADS2 DOI
Yulong Bao, Xiaoke Shang,

G. Hu

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156680 - 156680

Published: March 1, 2025

Language: Английский

Citations

0
Metformin activates the PI3K/AKT/BDNF axis to attenuate postoperative cognitive dysfunction DOI

Qing Wu,

Xiao-Yu Jia,

Shi-hua Zhang

et al.

Neuropharmacology, Journal Year: 2024, Volume and Issue: 265, P. 110262 - 110262

Published: Dec. 9, 2024

Language: Английский

Citations

1
Artemether Restores the Barrier Damage and Intestinal Dysbiosis to Alleviate Postoperative Cognitive Dysfunction Via Inhibiting Tlr4/Myd88/Traf6 Pathway DOI

Hong Yu,

Siqi Chen, Xuan Li

et al.

Published: Jan. 1, 2024

Objective : To study the effect of Artemether (ART) on postoperative cognitive dysfunction (POCD) rats and its barrier damage intestinal dysbiosis mediated by TLR4/MYD88/TRAF6 signaling pathway.Method: We simulated pathological process POCD in mice with an exploratory laparotomy animal model. A total 30 C57BL/6 were randomly divided into three groups: 10 for CON group, POCD+ART (40mg/kg daily) group . Behavioral tests used to examine function mice. 16S rRNA sequencing was employed detect gut microbiota changes. Alcian blue staining applied observe integrity. Two-photon imaging permeability blood-brain barrier. The molecules pathway alternations tested QPCR western blot. Immunofluorescence activation glial cells expression LPS hippocampus.Results: Our findings indicated that anesthesia surgery could impair spatial learning memory capacity aged mouse feces revealed significantly changed composition diversity microbiota, resulting destruction homeostasis increased production endotoxins. Meanwhile, integrity interfered surgery. Further, we artemether as a therapeutic agent, which maintained microbiome homeostasis, restored synaptic function, reversed restores alleviate via inhibiting pathway.

Language: Английский

Citations

0
The Role of the Intestinal Flora and Its Derivatives in Neurocognitive Disorders: A Narrative Review from Surgical Perspective DOI Creative Commons
Jian Huang,

T Qin,

Yun Bo

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: July 10, 2024

Abstract Perioperative neurocognitive dysfunction is a significant concern for population health, impacting postoperative recovery and increasing the financial burden on patients. With an number of surgical procedures being performed, prevention management perioperative have garnered attention. While factors such as age, lifestyle, genetics, education are known to influence development cognitive dysfunction, recent research has highlighted role gut microbiota in neurological health. An increased abundance pro-inflammatory can trigger worsen neuroinflammation, neuronal cell damage, impaired cellular autophagy. Moreover, inflammation-promoting disrupt immune function, impair neuroautophagy, affect production circulation extracellular vesicles neurotransmitters. These collectively play onset advancement impairment. This narrative review delves into molecular mechanisms through which their derivatives contribute impairment, focusing impact anesthesia surgery, changes microbial populations, impairment associations. The study suggests that alterations various bacterial species metabolites pre- post-surgery may be linked Furthermore, potential probiotics or prebiotics addressing discussed, offering promising avenue investigating treatment disorders.

Language: Английский

Citations

0