Journal of Gastrointestinal Oncology, Journal Year: 2024, Volume and Issue: 15(2), P. 800 - 802
Published: April 1, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4293 - 4293
Published: May 1, 2025
An increasing body of research indicates that the circulating microbiome plays a significant role in cancer initiation and progression treatment response. The genomic characteristics microorganisms may influence tumor immune microenvironment, thereby affecting therapeutic outcomes. However, whether can serve as prognostic biomarker for cervical patients its mechanistic microenvironment still requires further investigation. Univariate, Lasso, multivariate Cox regression analyses were utilized to identify microbial signatures associated with overall survival (OS) cancer. A Microbial Abundance Prognostic Score (MAPS) model was constructed based on these findings. nomogram integrated clinical features MAPSs developed predict OS rates Blood data combined matched RNA-seq analyze differences between high- low-MAPS groups, elucidating impact MAPS microenvironment. Finally, potential application predicting efficacy immunotherapy chemotherapy assessed. predictive model, which includes 15 microorganisms, has shown independent value Integrating into improved accuracy predictions. Combined gene revealed interactions microbiomes drug sensitivity analysis indicated predictor chemotherapy’s efficacy. Our findings suggest hold promise novel biomarkers inform personalized strategies Further large-scale multicenter studies are warranted validate utility MAPS.
Language: Английский
Citations
0
Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(3)
Published: April 1, 2024
Abstract Intratumoral microbiota (ITM) are microorganisms present in tumor cells. ITM participate development by affecting cells directly and the microenvironment (TME), indirectly. Alterations instigate changes DNA, activate oncogenic pathways, induce inflammatory responses, disrupt normal immune activity, facilitate secretion of effectors leading to progression, metastasis, or diminished therapeutic effects. varies significantly different types cancer disease states. The presence certain serves as a predictor various Thus, predicts tumorigenesis, grade, treatment efficacy, prognosis, making it potential biomarker. study aimed determine mechanisms which affects development, especially through TME; highlight significant enhancing diagnosis prognosis; outline future directions for research, with focus on innovative markers.
Language: Английский
Citations
3
Physiological Genomics, Journal Year: 2024, Volume and Issue: 56(8), P. 544 - 554
Published: May 29, 2024
The intratumoral microbiota may mediate the bladder tumor inflammatory response, thereby promoting epithelial-mesenchymal transition program and influencing immune infiltration.
Language: Английский
Citations
3
Microbiology Spectrum, Journal Year: 2024, Volume and Issue: 12(9)
Published: Aug. 5, 2024
ABSTRACT Growing evidence have indicated the crucial role of intratumor microbiome in a variety solid tumor. However, intratumoral gynecological malignancies is largely unknown. In present study, total 90 Han patients, including 30 patients with cancer cervix, ovary, and endometrium each were enrolled, composition was assessed by 16S rDNA amplicon high throughput sequencing. We found that diversity metabolic potential all three types very similar. Furthermore, shared few taxa collectively take up relative abundance positive rate, Pseudomonas sp ., Comamonadaceae gen. Bradyrhizobium Saccharomonospora Cutibacterium acnes , Rubrobacter Dialister micraerophilus Escherichia coli . Additionally, Haemophilus parainfluenzae Paracoccus cervical cancer, Pelomonas ovarian Enterococcus faecalis endometrial identified LDA to be representative bacterial strain. addition, alpha-fetoprotein (AFP) (correlation coefficient = −0.3714) negatively correlated ( r 0.4, 95% CI: 0.03 0.7) CA199 0.3955) positively associated .. CA125 −0.4451) −0.4, −0.7 −0.09) Porphyromonas sp. CEA −0.3868) −0.02) This study promoted our understanding malignancies. IMPORTANCE this we compositional spectrum tumor microbes among similar sharing differentiated substantial species owned uniquely. Certain species, mostly unreported, clinical characteristics. prompted offered for affecting biology cancers female reproductive system.
Language: Английский
Citations
3
Heliyon, Journal Year: 2024, Volume and Issue: 10(19), P. e38310 - e38310
Published: Sept. 23, 2024
Language: Английский
Citations
3
Clinical and Experimental Medicine, Journal Year: 2025, Volume and Issue: 25(1)
Published: May 7, 2025
This review provides an overview of research evidence focused on the microbial components essential to clinical cancer care, called oncobiota (the interaction human microbiota and cells). It specifically examines in central nervous system cancer,breast cancer, pancreatic liver lung cervical cancer. The literature reveals insufficient knowledge about organs once considered sterile. Many studies focus small, geographically specific patient groups, absence a reference (control) group complicates development profiles for selected cancers. Consequently, this aims analyze data reports role "sterile" resulting therapeutic or preventive implications. All relevant publications patients with cancers were provide most thorough analysis possible. Understanding significance pathomechanisms carcinogenesis may pave way targeted prevention methods. Furthermore, strategies based could represent novel area personalized treatment. Additionally, serve as additional diagnostic tool oncology.
Language: Английский
Citations
0
Journal of Ovarian Research, Journal Year: 2024, Volume and Issue: 17(1)
Published: July 5, 2024
Abstract Background Ovarian serous cystadenocarcinoma, accounting for about 90% of ovarian cancers, is frequently diagnosed at advanced stages, leading to suboptimal treatment outcomes. Given the malignant nature disease, effective biomarkers accurate prediction and personalized remain an urgent clinical need. Methods In this study, we analyzed microbial contents 453 cystadenocarcinoma 68 adjacent non-cancerous samples. A univariate Cox regression model was used identify microorganisms significantly associated with survival a prognostic risk score constructed using LASSO analysis. Patients were subsequently categorized into high-risk low-risk groups based on their scores. Results Survival analysis revealed that patients in group had higher overall rate. nomogram easy visualization model. Analysis immune cell infiltration checkpoint gene expression both showed parameters positively correlated level, indicating increased response groups. Conclusion Our findings suggest profiles may serve as viable indicators. This study provides novel insights potential impact intratumoral communities disease prognosis opens avenues future therapeutic interventions targeting these microorganisms.
Language: Английский
Citations
2
Cells, Journal Year: 2024, Volume and Issue: 13(15), P. 1279 - 1279
Published: July 30, 2024
The role of the microbiome in cancer and its crosstalk with tumor microenvironment (TME) has been extensively studied characterized. An emerging field research is concept intratumoral microbiome, which refers to residing within tumor. This primarily originates from local tumor-bearing tissue or translocating distant sites, such as gut. Despite increasing number studies on it remains unclear whether a driver bystander oncogenesis progression. review aims elucidate intricate development by exploring effects reshaping multileveled ecosystem tumors thrive, TME. To dissect complexity multitude layers TME, we distinguish six specialized microenvironments, namely, immune, metabolic, hypoxic, acidic, mechanical innervated microenvironments. Accordingly, attempt decipher each ultimately decode tumor-promoting tumor-suppressive impact. Additionally, portray an orchestrator milieu, fine-tuning responses distinct, microenvironments remodeling TME multifaceted manner.
Language: Английский
Citations
2
Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(11), P. 1083 - 1083
Published: Oct. 31, 2024
The human microbiota represents a heterogeneous microbial community composed of several commensal, symbiotic, and even pathogenic microorganisms colonizing both the external internal body surfaces. Despite term "microbiota" being commonly used to identify inhabiting gut, pieces evidence suggest presence different physiologically other organs. In this context, studies have also confirmed that microbes are integral components tumor tissue in types cancer, constituting so-called "intratumoral microbiota". intratumoral is closely related occurrence development cancer as well efficacy anticancer treatments. Indeed, can contribute carcinogenesis metastasis formation some directly cause DNA damage, while others induce activation proinflammatory responses or oncogenic pathways alter microenvironment (TME). All these characteristics make an interesting topic investigate for diagnostic prognostic purposes order improve management patients. This review aims gather most recent data on role development, progression, response treatment, its potential value.
Language: Английский
Citations
2
ONCOLOGIE, Journal Year: 2024, Volume and Issue: 26(3), P. 349 - 360
Published: Feb. 8, 2024
Abstract The effectiveness of cancer immunization is largely dependent on the tumor’s microenvironment, especially tumor immune microenvironment. Emerging studies say microbes exist in cells and cells, suggesting that these can affect state microenvironment tumor. Our comprehensive review navigates intricate nexus between intratumoral microorganisms their role biology modulation. Beginning with an exploration historical acknowledgment within tumors, article underscores evolution (TME) its subsequent implications. Using findings from recent studies, we delve into unique bacterial compositions across different types influence growth, DNA damage, regulation. Furthermore, illuminate potential therapeutic implications targeting microorganisms, emphasizing multifaceted roles drug delivery agents to immunotherapy enhancers. As advancements next-generation sequencing (NGS) technology redefine our understanding microbiome, importance discerning precise progression tailoring interventions. culminates by ongoing challenges pressing need for further research harness care.
Language: Английский
Citations
1