Molecular Docking Analysis, Chemical Composition, and Evaluation of Antibacterial and Insecticidal Activity of Salvia officinalis Essential Oil DOI Creative Commons
Safaa Rhaimi, Mohamed Taibi,

Mariam Barrahi

et al.

Journal of Food Processing and Preservation, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Salvia officinalis has been used for so many years as a traditional remedy and still in pharmaceutical, cosmetics, food industries, which made it an interesting subject researcher of natural alternatives. Enhancing the value Moroccan S. essential oil, is grown at Sidi Taibi Rabat‐Salé‐Kénitra Region, was goal this project, through analyzing its chemical composition assessing insecticidal antibacterial activities. This latter estimated by comparison with antibiotic ceftriaxone. The main components identified gas chromatography–mass spectrometry (GC‐MS) were camphor, eucalyptol (1,8‐cineole), α ‐thujone, β ledol, isoterpinolene values 19.72%, 15.64%, 15.05%, 9.74%, 7.27%, 3.24%, respectively. A study activity revealed that while ceftriaxone seemed useless against bacteria tested (all proved resistant to antibiotic), oil showed inhibitory effect on four tested, MIC ranging from 1/100 1/500 CMB 1/100. Using several dosages pure oils (0, 1, 5, 10, 20 μ L), fumigant toxicity ascertained. mortality rate individuals Sitophilus oryzae Rhyzopertha dominica reached 100% when applying dose 10.00 L/L air during 36 h exposure 24 R. . LC 50 determined 2.51 6.02 successively, LC95 5.45 12.61 over 12 successively. Molecular docking analysis ledol potent inhibitor three key enzymes involved mainly acetylcholinesterase (AChE), γ ‐aminobutyric acid receptor (GABA), ryanodine receptor.

Language: Английский

Functionalized Triazoles: Design, Synthesis and Chemical Characterization of 1,2,3-triazolylmethylthio-1,3,4-oxadiazole derivatives as Insecticidal and Antibacterial Agents DOI
Hany M. Abd El‐Lateef, Mai M. Khalaf, Mohamed Gouda

et al.

Journal of the Indian Chemical Society, Journal Year: 2025, Volume and Issue: 102(2), P. 101578 - 101578

Published: Jan. 11, 2025

Language: Английский

Citations

1
Green synthesis, characterization, and bio-efficacy of novel benzamides as insect growth regulator (IGR) analogues against Spodoptera frugiperda DOI
Hany M. Abd El‐Lateef, Mai M. Khalaf, Antar A. Abdelhamid

et al.

Toxicological & Environmental Chemistry Reviews, Journal Year: 2025, Volume and Issue: 107(3), P. 409 - 427

Published: Feb. 23, 2025

According to the majority of problems caused by use insecticides, rapid enhancement resistance conventional chemical insecticide compounds is another significant impetus for creation new effective insecticidal agents. One keys meeting this challenge explore classes with diverse modes action. The safe and distinctively designed organic ingredients essential development in order reduce effects derivatives. So, we prepared that have structure analogues insect growth regulator pyriproxyfen then tested them against Spodoptera frugiperda. structures produced products were proven using elemental analysis spectroscopic results. When synthetic derivatives toxicity S. frugiperda, 4-(2-hydroxy-3-phenoxypropoxy)phenyl-1,4-bis(2E)-3-(4chlorophenyl)prop-2-en-1-one 3 showed high activity (LC50 = 26.8 mg/L) compared pyriproxyfen, while other components moderate low effectiveness. In addition to, some biological parameters, including adult longevity, pupal weight, fraction normal, deformed pupae, was also conducted. This work created a pathway identification novel class insecticides.

Language: Английский

Citations

0
In Silico and In Vitro Assessment Based Optimization of Potential Insecticidal Combination Against Fall Armyworm DOI

Shreosi Biswas,

S. B. Suby,

Aditi Kundu

et al.

Indian Journal of Entomology, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

The fall armyworm Spodoptera frugiperda (J E Smith) is an invasive pest, causing severe economic damage to maize. present study demonstrates mining of potential insecticidal molecules using in silico analysis and validating through vitro pot experiments. Emamectin benzoate chlorantraniliprole performed best block acetylcholine esterase with respective binding energies -37.6 -35.7 KJ/ mol multiple hydrogen hydrophobic interactions. showed the strongest (ΔG -41 mol) followed by -34.3 inhibit ryanodine receptors, whereas, -27.2 emamectin benzoate(ΔG -26.3 GABA. In activity revealed strong action chlorantraniliprole(LC500.039 ppm) (LC50 0.027 ppm), however their combined effect maintaining0.75-1:0.9-2.5 (%, w/w) was highly promising LC50 0.01 ppm. SBOD-23 formulation consisting both insecticides at a concentration 20 times (ppm) least whorl maize highest plant weight without any phytotoxicity.

Language: Английский

Citations

0
Exploration of Some Thieno[2,3-b]pyridines, Thieno[3,2-d]pyrimidinones, and Thieno[3,2-d][1,2,3]triazinones as Insecticidal Agents Against Aonidiella aurantii DOI
Etify A. Bakhite, Mohamed A. Gad,

Esraa Khamies

et al.

Russian Journal of Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 51(2), P. 816 - 826

Published: April 1, 2025

Language: Английский

Citations

0
New Prospective Insecticidal Agents Based on N‐(arylcarbamothioyl)arylmide Derivatives Against Spodoptera frugiperda: Design, Synthesis, Toxicological, Biological, Biomedical Studies and Antibacterial Activity DOI
Mai M. Khalaf, Hany M. Abd El‐Lateef, Mohamed Gouda

et al.

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: 21(11)

Published: July 22, 2024

Abstract In this work, a novel series of N ‐(arylcarbamothioyl)arylmide) 2–11 were synthesized by treating One‐Pot three‐multicomponent Aroyl chloride, ammonium isothiocyanate and amine compounds under refluxing conditions. Using spectroscopic methods, the chemical structure novelty developed investigated. After five days, proposed derivatives’ insecticidal bioassay was assessed using median lethal concentration (LC 50 ) against second & fourth larvae Spodoptera frugiperda as toxicity agents. The findings showed that, to varying degrees, every tested substance exerted effects on S. in both their instars. Compound 9 most poisonous them all, having an LC instars 60.45 123.21 mg/L, respectively. Additionally, few biological biochemical characteristics substances that generated lab setting also looked at. Furthermore, work discusses how discover may one day be employed Finally, all designed components monitored for antibacterial effectiveness toward Gram‐positive Gram‐negative bacteria.

Language: Английский

Citations

2
Synthesis, characterization, insecticidal activity and antibacterial evaluation of some heterocyclic compounds containing 1,2,3-triazoles moiety DOI
Mai M. Khalaf, Hany M. Abd El‐Lateef, Mohamed Gouda

et al.

Journal of the Indian Chemical Society, Journal Year: 2024, Volume and Issue: 101(12), P. 101466 - 101466

Published: Nov. 12, 2024

Language: Английский

Citations

2
Functionalized Carbohydrazide: Synthesis, Insecticide Evaluation, Biological and Histological Studies of some New Carbohydrazide Derivatives against Spodoptera frugiperda DOI
Ali M. Drar,

Thuraya A.A. M. Al-Saadi,

Omar M. Elhady

et al.

Journal of the Indian Chemical Society, Journal Year: 2024, Volume and Issue: 101(12), P. 101464 - 101464

Published: Nov. 6, 2024

Language: Английский

Citations

1
Molecular Docking Analysis, Chemical Composition, and Evaluation of Antibacterial and Insecticidal Activity of Salvia officinalis Essential Oil DOI Creative Commons
Safaa Rhaimi, Mohamed Taibi,

Mariam Barrahi

et al.

Journal of Food Processing and Preservation, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Salvia officinalis has been used for so many years as a traditional remedy and still in pharmaceutical, cosmetics, food industries, which made it an interesting subject researcher of natural alternatives. Enhancing the value Moroccan S. essential oil, is grown at Sidi Taibi Rabat‐Salé‐Kénitra Region, was goal this project, through analyzing its chemical composition assessing insecticidal antibacterial activities. This latter estimated by comparison with antibiotic ceftriaxone. The main components identified gas chromatography–mass spectrometry (GC‐MS) were camphor, eucalyptol (1,8‐cineole), α ‐thujone, β ledol, isoterpinolene values 19.72%, 15.64%, 15.05%, 9.74%, 7.27%, 3.24%, respectively. A study activity revealed that while ceftriaxone seemed useless against bacteria tested (all proved resistant to antibiotic), oil showed inhibitory effect on four tested, MIC ranging from 1/100 1/500 CMB 1/100. Using several dosages pure oils (0, 1, 5, 10, 20 μ L), fumigant toxicity ascertained. mortality rate individuals Sitophilus oryzae Rhyzopertha dominica reached 100% when applying dose 10.00 L/L air during 36 h exposure 24 R. . LC 50 determined 2.51 6.02 successively, LC95 5.45 12.61 over 12 successively. Molecular docking analysis ledol potent inhibitor three key enzymes involved mainly acetylcholinesterase (AChE), γ ‐aminobutyric acid receptor (GABA), ryanodine receptor.

Language: Английский

Citations

0