Adult risk groups for vaccine preventable respiratory infections: an overview of the UK environment DOI Creative Commons
Charles Reynard, James Campling, Adam Gordon

et al.

Expert Review of Vaccines, Journal Year: 2024, Volume and Issue: 23(1), P. 1052 - 1067

Published: Nov. 14, 2024

Introduction Vaccine-preventable respiratory infections (VPRI) including those caused by Streptococcus pneumoniae, influenza, syncytial virus and severe acute syndrome coronavirus 2 (SARS-CoV-2) pose substantial challenges to health social care systems. In the UK, routine adult vaccination programs are in place. The objective of this article is review current evidence on impact four seasonal VPRIs adults risk group definitions explore strengths limitations recommendations, identify gaps for further research.

Language: Английский

Pathology of Diabetes-Induced Immune Dysfunction DOI Open Access
Michael P. Alexander,

Eric Cho,

Eiger Gliozheni

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7105 - 7105

Published: June 28, 2024

Diabetes is associated with numerous comorbidities, one of which increased vulnerability to infections. This review will focus on how diabetes mellitus (DM) affects the immune system and its various components, leading impaired proliferation cells induction senescence. We explore pathology diabetes-induced dysfunction may have similarities pathways "inflammaging", a persistent low-grade inflammation common in elderly. Inflammaging increase likelihood conditions such as rheumatoid arthritis (RA) periodontitis at younger age. bone marrow composition cellular senescence, combination advanced age also lymphopoiesis by increasing myeloid differentiation reducing lymphoid differentiation. Consequently, this leads reduced response both innate adaptive phases, resulting higher infection rates, vaccine response, cells' senescence diabetics. some drugs induce despite their benefits glycemic control.

Language: Английский

Citations

9
Hospitalisation from seasonal influenza among persons with type 1 diabetes: a cohort study from the Swedish National Diabetes Register DOI Creative Commons
Elin Allansson Kjölhede, Hanne Krage Carlsen,

Oliver Martyn

et al.

BMJ Open, Journal Year: 2025, Volume and Issue: 15(2), P. e084165 - e084165

Published: Feb. 1, 2025

Objectives The aim of this study was to investigate the risk severe influenza resulting in hospitalisation among adults with type 1 diabetes (T1D). Design Nationwide cohort using register data. Settings Data from National Diabetes Register (NDR) linked Swedish Patient Register, Statistics Sweden and Population Register. Participants Persons T1D NDR n=35 596 control persons matched on age, sex county residence, n=155 590. Primary secondary outcomes Hospitalisation seasonal October 2013 December 2019. Season-wise incidence HRs were analysed group compared controls. Secondary associations between clinical variables due for T1D. Results There 347 (1.0%) admissions 332 (0.2%) group. overall rate 16.9/10 000 person-years 3.6/10 had an unadjusted HR 4.7 (95% CI 4.0 5.5) during period 3.4 2.9 4.0) when adjusted sex, socioeconomic factors chronic medical conditions at baseline. Within cohort, individuals hospitalised older, more often smokers, lower glomerular filtration a previous history ischaemic heart disease stroke. Conclusions To our knowledge, is first large highlight that have threefold higher controls general population. It important healthcare professionals acknowledge excess risk, particularly older T1D, who cardiovascular reduced kidney function.

Language: Английский

Citations

0
Exploring genetic loci linked to COVID-19 severity and immune response through multi-trait GWAS analyses DOI Creative Commons

Ziang Meng,

Chumeng Zhang, Shuai Liu

et al.

Frontiers in Genetics, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 17, 2025

COVID-19 severity has been linked to immune factors, with excessive responses like cytokine storms contributing mortality. However, the genetic basis of these is not well understood. This study aimed explore connection between and blood cell traits, given their close relationship immunity. GWAS summary statistics for counts were analyzed using Linkage Disequilibrium Score Regression (LDSC) estimate correlations heritabilities. For traits significant correlations, a Multi-Trait Analysis (MTAG) was performed identify pleiotropic loci shared counts. Our MTAG analysis identified four associated severity, five hospitalized cases, one locus related general patients. Among these, two novel in high-risk population, rs55779981 located near RAVER1 rs73009538 CARM1. In patients, previously unrecognized detected, namely, rs115545251 GFI1 rs3181049 RAVER1, while rs11065822 CUX2 emerged as newly locus. We also potential target genes, including those involved inflammation signaling (CARM1), endothelial dysfunction (INTS12), antiviral response (RAVER1), which may require further investigation. offers insights into overlap suggesting directions future research clinical exploration.

Language: Английский

Citations

0
Adult risk groups for vaccine preventable respiratory infections: an overview of the UK environment DOI Creative Commons
Charles Reynard, James Campling, Adam Gordon

et al.

Expert Review of Vaccines, Journal Year: 2024, Volume and Issue: 23(1), P. 1052 - 1067

Published: Nov. 14, 2024

Introduction Vaccine-preventable respiratory infections (VPRI) including those caused by Streptococcus pneumoniae, influenza, syncytial virus and severe acute syndrome coronavirus 2 (SARS-CoV-2) pose substantial challenges to health social care systems. In the UK, routine adult vaccination programs are in place. The objective of this article is review current evidence on impact four seasonal VPRIs adults risk group definitions explore strengths limitations recommendations, identify gaps for further research.

Language: Английский

Citations

1