Chitin-glucan improves important pathophysiological features of irritable bowel syndrome DOI Creative Commons

Caroline Valibouze,

Caroline Dubuquoy,

Philippe Chavatte

et al.

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(16), P. 2258 - 2271

Published: April 26, 2024

Irritable bowel syndrome (IBS) is one of the most frequent and debilitating conditions leading to gastroenterological referrals. However, recommended treatments remain limited, yielding only limited therapeutic gains. Chitin-glucan (CG) a novel dietary prebiotic classically used in humans at dosage 1.5-3.0 g/d considered safe food ingredient by European Food Safety Authority. To provide an alternative approach managing patients with IBS, we performed preclinical molecular, cellular, animal studies evaluate role chitin-glucan main pathophysiological mechanisms involved IBS.

Language: Английский

Irritable bowel syndrome: Epidemiology, overlap disorders, pathophysiology and treatment DOI Creative Commons

Kai-Yue Huang,

Fengyun Wang,

Mi Lv

et al.

World Journal of Gastroenterology, Journal Year: 2023, Volume and Issue: 29(26), P. 4120 - 4135

Published: July 6, 2023

Coronavirus disease 2019 (COVID-19) has several extrapulmonary symptoms. Gastrointestinal (GI) symptoms are among the most frequent clinical manifestations of COVID-19, with severe consequences reported in elderly patients. Furthermore, impact COVID-19 on patients pre-existing digestive diseases still needs to be fully elucidated, particularly older population. This review aimed investigate GI tract, liver, and pancreas individuals without previous diseases, a particular focus elderly, highlighting distinctive characteristics observed this Finally, effectiveness adverse events anti-COVID-19 vaccination disorders peculiarities found discussed.

Language: Английский

Citations

50
Pasteurized Akkermansia muciniphila improves irritable bowel syndrome-like symptoms and related behavioral disorders in mice DOI Creative Commons
Maëva Meynier,

Valentine Daugey,

Geoffroy Mallaret

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Jan. 3, 2024

Gut – brain communications disorders in irritable bowel syndrome (IBS) are associated with intestinal microbiota composition, increased gut permeability, and psychosocial disturbances. Symptoms of IBS difficult to medicate, hence much research is being made into alternative approaches. This study assesses the potential a treatment pasteurized Akkermansia muciniphila for alleviating IBS-like symptoms two mouse models different etiologies. Two clinically relevant animal were used mimic C57BL6/J mice: neonatal maternal separation (NMS) paradigm Citrobacter rodentium infection model. In both models, colonic sensitivity, fecal composition IL-22 expression evaluated. The cognitive performance emotional state animals also assessed by several tests C. neuromodulation ability A. was on primary neuronal cells from mice dorsal root ganglia using ratiometric calcium imaging approach. administration significantly reduced hypersensitivity accompanied reinforcement barrier function. Beneficial effects have been observed anxiety-like behavior memory defects Finally, neuroinhibitory effect exerted stimulated algogenic substances such as capsaicin inflammatory soup. Our findings demonstrate novel anti-hyperalgesic properties muciniphila, which therefore may beneficial relieving pain anxiety subjects IBS.

Language: Английский

Citations

31
Treatment of non-constipated irritable bowel syndrome with the histamine 1 receptor antagonist ebastine: a randomised, double-blind, placebo-controlled trial DOI
Lisse Decraecker, Danny De Looze,

David P. Hirsch

et al.

Gut, Journal Year: 2024, Volume and Issue: unknown, P. gutjnl - 331634

Published: Jan. 8, 2024

We evaluated the histamine 1 receptor antagonist ebastine as a potential treatment for patients with non-constipated irritable bowel syndrome (IBS) in randomised, placebo-controlled phase 2 study.

Language: Английский

Citations

16
Effects of a Low-FODMAP Diet on Irritable Bowel Syndrome in Both Children and Adults—A Narrative Review DOI Open Access
Ionela Daniela Morariu,

Liliana Avasilcăi,

Mădălina Vieriu

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(10), P. 2295 - 2295

Published: May 13, 2023

Irritable bowel syndrome is a typical gastrointestinal disease that causes bloating, flatulence, abdominal pain, diarrhoea, constipation, or alteration of the last two in adults and children. A diet low fermentable oligosaccharides, disaccharides, monosaccharides, polyols (FODMAP) one potential treatment strategies to reduce symptoms increase quality life. The present narrative review aims general overview current studies have evaluated efficacy low-FODMAP against other diets symptoms, nutrient intake children, lifestyle quality. research was performed using seven searchable databases, which included Cochrane Central Register Controlled Trials (CENTRAL), Database Systematic Reviews (CDSR), Excerpta Medica (EMBASE), Medline, PubMed, Scopus, Web Science, up March 2023. In conclusion, there significant evidence follow-up might be feasible first-line therapeutic strategy stomach discomfort, life for patients with irritable syndrome.

Language: Английский

Citations

36
Shenling Baizhu powder attenuates lard diet in a fatigued state-induced diarrhea via targeting microbial metabolites short chain fatty acids-mediated lipid metabolism DOI
Bo Qiao, Nenqun Xiao, Na Deng

et al.

3 Biotech, Journal Year: 2024, Volume and Issue: 14(9)

Published: Aug. 16, 2024

Language: Английский

Citations

15
Ameliorating effects of transcutaneous auricular vagus nerve stimulation on a mouse model of constipation-predominant irritable bowel syndrome DOI Creative Commons
Jie Liu,

Qian Dai,

Tong Qu

et al.

Neurobiology of Disease, Journal Year: 2024, Volume and Issue: 193, P. 106440 - 106440

Published: Feb. 16, 2024

Limited treatment options have been shown to alter the natural course of constipation-predominant irritable bowel syndrome (IBS-C). Therefore, safer and more effective approaches are urgently needed. We investigated effects transcutaneous auricular vagus nerve stimulation (taVNS) in a mouse model IBS-C. In current study, C57BL/6 mice were randomly divided into normal control, IBS-C sham-electrostimulation (sham-ES), taVNS, drug groups. The taVNS on fecal pellet number, water content, gastrointestinal transit evaluated mice. assessed effect visceral hypersensitivity using colorectal distention test. 16S rRNA sequencing was used analyze microbiota experimental First, we found that increased compared with sham-ES group. Second, significantly decreased abdominal withdrawal reflex (AWR) score group, thus relieving hyperalgesia. Third, gut outcomes showed restored Lactobacillus abundance while increasing Bifidobacterium probiotic at genus level. Notably, number c-kit-positive interstitial cells Cajal (ICC) myenteric plexus region our study indicated effectively ameliorated ICC.

Language: Английский

Citations

11
Food Intolerances, Food Allergies and IBS: Lights and Shadows DOI Open Access
Andrea Pasta, Elena Formisano, Francesco Calabrese

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(2), P. 265 - 265

Published: Jan. 16, 2024

This narrative review delves into the intricate relationship between irritable bowel syndrome (IBS) and food intolerances. IBS, a chronic functional gastrointestinal disorder, is characterized by symptoms like abdominal pain altered habits. The prevalence of IBS has increased globally, especially among young adults. Food dietary habits play crucial role in management. About 85-90% patients report symptom exacerbation linked to specific consumption, highlighting strong connection intolerances IBS. often exhibit dose-dependent pattern, posing challenge identifying trigger foods. issue further complicated complex nature physiology varying compositions. discusses various patterns their impact on including low-FODMAP diet, gluten-free Mediterranean diet. It highlights importance personalized approach management, considering individual variability history. In conclusion, this emphasizes need for accurate diagnosis holistic management interplay factors pathophysiology. underlines patient education adherence treatment plans, acknowledging challenges posed triggers psychological restrictions.

Language: Английский

Citations

10
The Role and Applications of Artificial Intelligence in the Treatment of Chronic Pain DOI

Tiffany A. Meier,

Mohammad S. Refahi,

Gavin Hearne

et al.

Current Pain and Headache Reports, Journal Year: 2024, Volume and Issue: 28(8), P. 769 - 784

Published: June 1, 2024

Language: Английский

Citations

9
Piwi-interacting RNA biomarkers in gastrointestinal disease DOI

Xin-Yi Huang,

Shuxian Chen,

Zhenyu Wang

et al.

Clinica Chimica Acta, Journal Year: 2025, Volume and Issue: 569, P. 120182 - 120182

Published: Feb. 5, 2025

Language: Английский

Citations

1
Irritable Bowel Syndrome: A Hallmark of Psychological Distress in Women? DOI Creative Commons
Giuseppe Marano, Gianandrea Traversi, Roberto Pola

et al.

Life, Journal Year: 2025, Volume and Issue: 15(2), P. 277 - 277

Published: Feb. 11, 2025

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by abdominal pain, bloating, and altered habits. Women are disproportionately affected IBS due to complex interplay between genetic, environmental, psychosocial factors, along with crucial role of the gut–brain axis in modulating both function pain perception. Evidence suggests strong association psychological distress symptoms. report higher levels compared men, sex biological variable that shapes several aspects mechanisms, epidemiology, clinical manifestations IBS. This paper explores bidirectional relationship factors focus on women. Stress, anxiety, depression, childhood trauma contribute symptomatology, societal unique women may exacerbate this condition. Strategies for integrated care approaches gender-specific treatment strategies improve patient outcomes quality life needed.

Language: Английский

Citations

1