Rediscovering histology – the application of artificial intelligence in inflammatory bowel disease histologic assessment

Therapeutic Advances in Gastroenterology, Journal Year: 2025, Volume and Issue: 18

Published: Jan. 1, 2025

Integrating artificial intelligence (AI) into histologic disease assessment is transforming the management of inflammatory bowel (IBD). AI-aided histology enables precise, objective evaluations activity by analysing whole-slide images, facilitating accurate predictions remission (HR) in ulcerative colitis and Crohn’s disease. Additionally, AI shows promise predicting adverse outcomes therapeutic responses, making it a promising tool for clinical practice trials. By leveraging advanced algorithms, enhances diagnostic accuracy, reduces variability streamlines histological workflows settings. In trials, aids assessing endpoints, enabling real-time analysis, standardising supporting adaptive trial designs. Recent advancements are further refining digital pathology IBD. New developments multimodal models integrating clinical, endoscopic, molecular data pave way comprehensive approach to precision medicine Automated intestinal barrier healing – deeper level beyond endoscopic HR improved outcome prediction patient management. Preliminary evidence also suggests that applied colitis-associated neoplasia can aid detection, characterisation profiling lesions, holding potential enhanced dysplasia organ-sparing approaches. Although challenges remain standardisation, validation through randomised controlled trials ethical considerations. poised revolutionise IBD advancing towards more personalised efficient care model, while path full implementation may be lengthy. However, transformative impact on already shining through.

Language: Английский

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Schwann cells and enteric glial cells: Emerging stars in colorectal cancer

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: 1879(5), P. 189160 - 189160

Published: July 24, 2024

Language: Английский

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Confocal Endomicroscopy Intestinal Epithelial Barrier Abnormalities in Individuals Without Documented Gastro‐Intestinal Disease

United European Gastroenterology Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

ABSTRACT Background and aims Probe‐based confocal endomicroscopy (pCLE) allows real‐time microscopic visualization of the intestinal mucosa surface layers. Despite remission achieved through anti‐tumor necrosis factor or vedolizumab therapy, anomalies in epithelial barrier are observed inflammatory bowel disease (IBD) patients. Our study aimed to assess these abnormalities non‐IBD individuals compare them with IBD patients endoscopic identify associated factors. Methods The involved 84 patients, 40 under biologic therapy for over 6 months remission, 44 without irritable syndrome (IBS) undergoing colorectal screening colonoscopy. White light endoscopy probe‐based laser were performed ileum, right colon, transverse left rectum. Demographic, clinical, biological, morphological factors examined. Results pCLE revealed both those such as fluorescein leakage, blood vessel dilatation, hypervascularization across all segments, well gaps crypt dilatation colon. Comparing two groups, exhibited slightly more increased leakage fewer Abnormalities frequent cases hypertension ( p = 0.03), dyslipidemia 0.02), female gender selective serotonin reuptake inhibitor family history 0.04) cancer 0.03). Conclusion Confocal present colonoscopy remission. Further research is needed understand pathophysiological mechanisms their clinical impact.

Language: Английский

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Paradigm Shift in Inflammatory Bowel Disease Management: Precision Medicine, Artificial Intelligence, and Emerging Therapies

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(5), P. 1536 - 1536

Published: Feb. 25, 2025

Inflammatory bowel disease (IBD) management stands at the cusp of a transformative era, with recent breakthroughs heralding paradigm shift in treatment strategies. Traditionally, IBD therapeutics revolved around immunosuppressants, but landscape has evolved significantly. Recent approvals etrasimod, upadacitinib, mirikizumab, and risankizumab have introduced novel mechanisms action, offering renewed hope for patients. These medications represent departure from status quo, breaking years therapeutic stagnation. Precision medicine, involving Artificial Intelligence, is pivotal aspect this evolution, tailoring treatments based on genetic profiles, characteristics, individual responses. This approach optimizes efficacy, paves way personalized care. Yet, rising cost therapies, notably biologics, poses challenges, impacting healthcare budgets patient access. Ongoing research strives to assess cost-effectiveness, guiding policy decisions ensure equitable access advanced treatments. Looking ahead, future holds great promise. Emerging precision ongoing into targets promise reshape landscape. As these advances continue unfold, patients can anticipate brighter future, one marked by more effective, personalized, accessible

Language: Английский

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AI-enabled ‘endo-histo-omics’: breaking down intestinal barriers in IBD

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Language: Английский

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Intestinal Permeability In Vivo in Patients With Inflammatory Bowel Disease: Comparison of Active Disease and Remission

Inflammatory Bowel Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Abstract Background and Aims Inflammatory bowel disease (IBD) is associated with altered mucus increased intestinal permeability (IP). Prior reports on in IBD typically used lactulose-to-mannitol ratio (LMR). Food contamination 12C-mannitol a significant potential confounder IP assessment. We aimed to compare small (SI) colonic (COL) IBD, both active (ACT) remission (REM), normal healthy volunteers (NHV). Methods activity was based Simple Endoscopic Score for Crohn’s Disease (SES-CD) Mayo endoscopy score ulcerative colitis (UC). performed 24-hour test using 100 mg 13C-mannitol 1000 lactulose urine collected during 0-2, 2-8, 8-24 hours. The primary endpoint excretion of 2-24 hours reflecting SI COL permeability. Results Among 17 CD patients, 7 were ACT (SES-CD >6), 10 REM 0-2). 20 UC had (Mayo 2-3), 0-1). Urinary excretions over higher than NHV: (13.8 [IQR 8.8, 18.7] NHV; 18.4 [15.6, 29.9] REM; 19.7 [13.8, 23.6] ACT, P = .003) (1.8 [1.3, 3.1] 3.6 [2.0, 5.0] 3.5 6.6] .006). There no difference between any timed collection. LMR at (or 2-8 hours) not statistically the 3 groups (0.014 [0.010, 0.021] 0.016 0.023] [0.012, 0.038] .237). Conclusions Intestinal validated vivo assay relative persists remission.

Language: Английский

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Endoscopic healing in IBD: Still the target to achieve?

Digestive and Liver Disease, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Mucosal healing is the mainstream goal of modern treat-to-target strategy as it associated with a significantly more favorable disease course in IBD patients either ulcerative colitis or Crohn's disease.Recent advances endoscopic imaging technologies have overcome traditional concept mucosal assessed conventional white light imaging, allowing for multiple levels up to boundaries molecular and functional evaluation.In this review, we focused on emerging strategies assess ileocolonic disease, examining their pros cons real life practice.

Language: Английский

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Incorporating zinc coordination driven nanozyme into chitosan and hyaluronic acid based nanoplatform for scavenging H2S/ROS in managing inflammatory bowel disease

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123501 - 123501

Published: March 1, 2025

Language: Английский

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TREM2 Activation Relieves TMJOA by Stabilizing the Synovial Barrier via Siglec1

Journal of Dental Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Triggering receptor expressed on myeloid cells 2 (TREM2) is an immune that plays a vital role in innate responses. This study aims to investigate the effect of TREM2 synovial barrier homeostasis and synovitis during temporomandibular joint osteoarthritis (TMJOA). The expression level decreased synovium both patients with TMJOA mouse model TMJOA, accompanied by breakdown. overexpression inhibits macrophage inflammatory response ex vivo relieves inflammation, cartilage degeneration, destruction monosodium iodoacetate–induced mice. RNA-seq analysis reveals Siglec1 serves as downstream signal downregulated after activation. Further vitro experiments demonstrate rhSiglec1 treatment promotes synthesis release cytokines, such interleukin-6 RANTES, macrophages reverses alleviation activation disorders, degradation, bone destruction. Overall, this verifies alleviates pathology maintaining inhibiting inflammation. These findings provide new insight into mechanism pathogenesis TMJOA.

Language: Английский

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Unveiling the fungal frontier: mycological insights into inflammatory bowel disease

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 26, 2025

Inflammatory bowel disease (IBD) is a chronic recurrent gastrointestinal that seriously affects the quality of life patients around world. It characterized by abdominal pain, diarrhea, and mucous bloody stools. There an urgent need for more accurate diagnosis effective treatment IBD. Accumulated evidence suggests gut microbiota plays important role in occurrence development inflammation. However, most studies on IBD have focused bacteria, while fungal microorganisms been neglected. Fungal dysbiosis can activate host protective immune pathway related to integrity epithelial barrier release variety pro-inflammatory cytokines trigger inflammatory response. Dectin-1, CARD9, IL-17 signaling pathways may be drivers dysbacteriosis In addition, fungal-bacterial interactions fungal-derived metabolites also play role. Based this information, we explored new strategies targeting intestinal group its metabolites, such as probiotics, antifungal drugs, diet therapy, fecal transplantation (FMT). This review aims summarize pathogenesis IBD, provide insights directions further research emerging field.

Language: Английский

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