The cytokines in tumor microenvironment: from cancer initiation-elongation-progression to metastatic outgrowth DOI
Rajalaxmi Pradhan,

Anushka Kundu,

Chanakya Nath Kundu

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: 196, P. 104311 - 104311

Published: March 3, 2024

Language: Английский

Unraveling the enigma of tumor-associated macrophages: challenges, innovations, and the path to therapeutic breakthroughs DOI Creative Commons
Shengwen Shao, Huilai Miao, Wenxue Ma

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 14, 2023

Tumor-associated macrophages (TAMs) are integral to the tumor microenvironment (TME), influencing cancer progression significantly. Attracted by cell signals, TAMs exhibit unparalleled adaptability, aligning with dynamic milieu. Their roles span from promoting growth and angiogenesis modulating metastasis. While substantial research has explored fundamentals of TAMs, comprehending their adaptive behavior, leveraging it for novel treatments remains challenging. This review delves into TAM polarization, metabolic shifts, complex orchestration cytokines chemokines determining functions. We highlight complexities TAM-targeted focusing on adaptability potential variability in therapeutic outcomes. Moreover, we discuss synergy integrating TAM-focused strategies established treatments, such as chemotherapy, immunotherapy. Emphasis is laid pioneering methods like reprogramming immunotherapy adoption single-cell technologies precision intervention. synthesis seeks shed light TAMs’ multifaceted cancer, pinpointing prospective pathways transformative enhancing modalities oncology.

Language: Английский

Citations

29
The role of metabolic reprogramming of tumor-associated macrophages in shaping the immunosuppressive tumor microenvironment DOI Creative Commons

Lunxu Li,

Yu Tian

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 161, P. 114504 - 114504

Published: March 14, 2023

Macrophages are potent immune effector cells in innate immunity and exert dual-effects the tumor microenvironment (TME). Tumor-associated macrophages (TAMs) make up a significant portion of TME cells. Similar to M1/M2 macrophages, TAMs also highly plastic, their functions regulated by cytokines, chemokines other factors TME. The metabolic changes significantly associated with polarization towards protumour or antitumour phenotype. metabolites generated via TAM reprogramming turn promote progression tolerance. In this review, we explore terms energy, amino acid fatty metabolism potential roles these suppression.

Language: Английский

Citations

26
The ALOX5 inhibitor Zileuton regulates tumor-associated macrophage M2 polarization by JAK/STAT and inhibits pancreatic cancer invasion and metastasis DOI

Weimin Hu,

Si-Qing Liu,

Kongfan Zhu

et al.

International Immunopharmacology, Journal Year: 2023, Volume and Issue: 121, P. 110505 - 110505

Published: June 20, 2023

Language: Английский

Citations

26
Biomaterial-based platforms for modulating immune components against cancer and cancer stem cells DOI
Nimeet Desai, Uzma Hasan,

K Jeyashree

et al.

Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 161, P. 1 - 36

Published: March 10, 2023

Language: Английский

Citations

24
The cytokines in tumor microenvironment: from cancer initiation-elongation-progression to metastatic outgrowth DOI
Rajalaxmi Pradhan,

Anushka Kundu,

Chanakya Nath Kundu

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: 196, P. 104311 - 104311

Published: March 3, 2024

Language: Английский

Citations

11