Targeting tumor-associated macrophages: Novel insights into immunotherapy of skin cancer

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

The incidence of skin cancer is currently increasing, and conventional treatment options inadequately address the demands disease management. Fortunately, recent rapid advancement immunotherapy, particularly immune checkpoint inhibitors (ICIs), has ushered in a new era for numerous patients. However, efficacy immunotherapy remains suboptimal due to impact tumor microenvironment (TME). Tumor-associated macrophages (TAMs), major component TME, play crucial roles invasion, metastasis, angiogenesis, evasion, significantly impacting development. Consequently, TAMs have gained considerable attention years, their been extensively studied various tumors. specific regulatory mechanisms remain unclear. This paper aims elucidate origin classification TAMs, investigate interactions between cells, comprehensively understand precise by which contribute pathogenesis different types cancer, finally discuss current strategies targeting cancer. With emphasis on interrelationship this posits that therapeutic modalities centered hold promise augmenting harmonizing with prevailing clinical interventions thereby charting novel trajectory advancing landscape immunotherapeutic approaches

Language: Английский

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Pseudostellaria heterophylla (Miq.) Pax, a Traditional Folk Medicine, Ameliorates Colorectal Cancer by Remodeling the Tumor Immune Microenvironment

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: 342, P. 119362 - 119362

Published: Jan. 17, 2025

Language: Английский

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Interactions between cancer cells and tumor-associated macrophages in tumor microenvironment

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 189344 - 189344

Published: May 1, 2025

Language: Английский

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The myokine CCL5 recruits subcutaneous preadipocytes and promotes intramuscular fat deposition in obese mice

AJP Cell Physiology, Journal Year: 2024, Volume and Issue: 326(5), P. C1320 - C1333

Published: March 18, 2024

Intramuscular fat (IMF) refers to the lipid stored in skeletal muscle tissue. The number and size of intramuscular adipocytes are primary factors that regulate IMF content. can be derived from either situ or ectopic migration. In this study, it was discovered regulation levels is achieved through chemokine (C-C motif) ligand 5 (CCL5)/chemokine receptor (CCR5) pathway by modulating adipocyte coculture experiments, C2C12 myotubes were more effective promoting migration 3T3-L1 preadipocytes than myoblasts, along with increasing CCL5. Correspondingly, overexpressing CCR5, one receptors CCL5, facilitated their Conversely, application CCL5/CCR5 inhibitor, MARAVIROC (MVC), reduced vivo, transplanted experiments subcutaneous adipose tissue (SCAT) transgenic mice expressing green fluorescent protein (GFP) provided evidence injecting recombinant CCL5 (rCCL5) into promotes muscle. level increased obesity. Blocking axis MVC inhibited deposition, whereas elevated promoted deposition obese mice. These results establish a link between pathway, which could have potential for

Language: Английский

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Integrin β8 Facilitates Macrophage Infiltration and Polarization by Regulating CCL5 to Promote LUAD Progression

Advanced Science, Journal Year: 2024, Volume and Issue: 12(2)

Published: Nov. 13, 2024

Abstract The tumor microenvironment (TME) influences cancer progression and metastasis. Integrin β 8 (ITG 8), a member of the integrin family, is upregulated in various cancers. In this study, it determined as key factor that mediates interaction between lung adenocarcinoma (LUAD) cells macrophages. Increased expression levels ITG are associated with increased numbers CD163+ macrophages poor prognosis LUAD patients. overexpression promotes polarization THP‐1 toward M2 phenotype. contrast, TCM (conditioned medium from co‐culture system) 8‐overexpressing A549 promoted proliferation invasion cells. Mechanistically, chemokine (C‐C motif) ligand 5 (CCL5) plays an important role mediating 8‐induced macrophage polarization, phosphoinositide 3‐kinase (PI3K)/AKT serine/threonine kinase (AKT)/interferon regulatory 9 (IRF9) pathway involved process. Moreover, interleukin (IL8) 10 (IL10) produced by M2‐like regulate through spi‐1 proto‐oncogene (SPI1). This study elucidates feedback mechanism

Language: Английский

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Single-cell sequencing reveals VEGFR as a potential target for CAR-T cell therapy in chordoma

British Journal of Cancer, Journal Year: 2024, Volume and Issue: 130(10), P. 1609 - 1620

Published: April 11, 2024

Language: Английский

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Immune microenvironment and immunotherapy for chordoma

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: June 24, 2024

Chordoma, as a rare, low-grade malignant tumor that tends to occur in the midline of body, grows slowly but often severely invades surrounding tissues and bones. Due severe invasion damage tissues, chordoma is difficult be gross totally resected surgery, progression residual unavoidable. Besides, insensitive conventional radiotherapy chemotherapy, thus finding effective treatment methods for urgent. Nowadays, immunotherapy has made series breakthroughs shown good therapeutic effects kinds tumors, which brings new insights into tumors without strategies. With deepening research on immunotherapy, some studies focused immune microenvironment have been published, most them concentrated infiltration cells, expression tumor-specific antigen or checkpoint expression. On this basis, are under way, encouraging results. In review, we reviewed about chordoma, combined with existing clinical trials data, hoping clarify frontiers limitations research, provide reference follow-up chordoma.

Language: Английский

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Systemic Trafficking of Macrophages in Implant Wear Debris-Induced Periprosthetic Osteolysis

SLAS TECHNOLOGY, Journal Year: 2025, Volume and Issue: unknown, P. 100254 - 100254

Published: Feb. 1, 2025

Periprosthetic osteolysis (PPOL) is a significant complication post-joint replacement, often instigated by implant wear debris, leading to chronic inflammation and bone resorption. Herein, this review summarizes the immune mechanisms of PPOL, specifically, processes where macrophages are recruited which trigger inflammatory cascades, role chemokines that facilitate macrophage migration, including CCL2, CCL3, CCL4, CCL5, CXCL8, CX3CL1, XCL1. This highlights novel findings on these suggests illustrating offers promising avenues for future therapeutic strategies prevent treat such as potential use anti-inflammatory drugs.

Language: Английский

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The immune response of upper and lower airway epithelial cells to Aspergillus fumigatus and Candida albicans-derived β-glucan in Th17 type cytokine environment

Archives of Microbiology, Journal Year: 2025, Volume and Issue: 207(4)

Published: Feb. 24, 2025

Language: Английский

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A comprehensive review on targeting diverse immune cells for anticancer therapy: beyond immune checkpoint inhibitors

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: 210, P. 104702 - 104702

Published: March 22, 2025

Although immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, primary resistance and acquired continue to limit their efficacy for many patients. To address enhance the anti-tumor activity within tumor microenvironment (TIME), numerous therapeutic strategies targeting both innate adaptive cells emerged. These include combination therapies with ICIs, chimeric antigen receptor T-cell (CAR-T), macrophages (CAR-Ms) or natural killer cell (CAR-NK) therapy, colony stimulating factor 1 (CSF1R) inhibitors, dendritic (DC) vaccines, toll-like (TLR) agonists, cytokine therapies, chemokine inhibition. approaches underscore significant potential of TIME in treatment. This article provides a comprehensive up-to-date review mechanisms action various TIME, as well each type, aiming deepen understanding potential.

Language: Английский

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