Targeting tumor-associated macrophages: Novel insights into immunotherapy of skin cancer

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

The incidence of skin cancer is currently increasing, and conventional treatment options inadequately address the demands disease management. Fortunately, recent rapid advancement immunotherapy, particularly immune checkpoint inhibitors (ICIs), has ushered in a new era for numerous patients. However, efficacy immunotherapy remains suboptimal due to impact tumor microenvironment (TME). Tumor-associated macrophages (TAMs), major component TME, play crucial roles invasion, metastasis, angiogenesis, evasion, significantly impacting development. Consequently, TAMs have gained considerable attention years, their been extensively studied various tumors. specific regulatory mechanisms remain unclear. This paper aims elucidate origin classification TAMs, investigate interactions between cells, comprehensively understand precise by which contribute pathogenesis different types cancer, finally discuss current strategies targeting cancer. With emphasis on interrelationship this posits that therapeutic modalities centered hold promise augmenting harmonizing with prevailing clinical interventions thereby charting novel trajectory advancing landscape immunotherapeutic approaches

Language: Английский

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The myokine CCL5 recruits subcutaneous preadipocytes and promotes intramuscular fat deposition in obese mice

AJP Cell Physiology, Journal Year: 2024, Volume and Issue: 326(5), P. C1320 - C1333

Published: March 18, 2024

Intramuscular fat (IMF) refers to the lipid stored in skeletal muscle tissue. The number and size of intramuscular adipocytes are primary factors that regulate IMF content. can be derived from either situ or ectopic migration. In this study, it was discovered regulation levels is achieved through chemokine (C-C motif) ligand 5 (CCL5)/chemokine receptor (CCR5) pathway by modulating adipocyte coculture experiments, C2C12 myotubes were more effective promoting migration 3T3-L1 preadipocytes than myoblasts, along with increasing CCL5. Correspondingly, overexpressing CCR5, one receptors CCL5, facilitated their Conversely, application CCL5/CCR5 inhibitor, MARAVIROC (MVC), reduced vivo, transplanted experiments subcutaneous adipose tissue (SCAT) transgenic mice expressing green fluorescent protein (GFP) provided evidence injecting recombinant CCL5 (rCCL5) into promotes muscle. level increased obesity. Blocking axis MVC inhibited deposition, whereas elevated promoted deposition obese mice. These results establish a link between pathway, which could have potential for

Language: Английский

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Integrin β8 Facilitates Macrophage Infiltration and Polarization by Regulating CCL5 to Promote LUAD Progression

Advanced Science, Journal Year: 2024, Volume and Issue: 12(2)

Published: Nov. 13, 2024

Abstract The tumor microenvironment (TME) influences cancer progression and metastasis. Integrin β 8 (ITG 8), a member of the integrin family, is upregulated in various cancers. In this study, it determined as key factor that mediates interaction between lung adenocarcinoma (LUAD) cells macrophages. Increased expression levels ITG are associated with increased numbers CD163+ macrophages poor prognosis LUAD patients. overexpression promotes polarization THP‐1 toward M2 phenotype. contrast, TCM (conditioned medium from co‐culture system) 8‐overexpressing A549 promoted proliferation invasion cells. Mechanistically, chemokine (C‐C motif) ligand 5 (CCL5) plays an important role mediating 8‐induced macrophage polarization, phosphoinositide 3‐kinase (PI3K)/AKT serine/threonine kinase (AKT)/interferon regulatory 9 (IRF9) pathway involved process. Moreover, interleukin (IL8) 10 (IL10) produced by M2‐like regulate through spi‐1 proto‐oncogene (SPI1). This study elucidates feedback mechanism

Language: Английский

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Pseudostellaria heterophylla (Miq.) Pax, a Traditional Folk Medicine, Ameliorates Colorectal Cancer by Remodeling the Tumor Immune Microenvironment

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: 342, P. 119362 - 119362

Published: Jan. 17, 2025

Language: Английский

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Systemic Trafficking of Macrophages in Implant Wear Debris-Induced Periprosthetic Osteolysis

SLAS TECHNOLOGY, Journal Year: 2025, Volume and Issue: unknown, P. 100254 - 100254

Published: Feb. 1, 2025

Periprosthetic osteolysis (PPOL) is a significant complication post-joint replacement, often instigated by implant wear debris, leading to chronic inflammation and bone resorption. Herein, this review summarizes the immune mechanisms of PPOL, specifically, processes where macrophages are recruited which trigger inflammatory cascades, role chemokines that facilitate macrophage migration, including CCL2, CCL3, CCL4, CCL5, CXCL8, CX3CL1, XCL1. This highlights novel findings on these suggests illustrating offers promising avenues for future therapeutic strategies prevent treat such as potential use anti-inflammatory drugs.

Language: Английский

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A comprehensive review on targeting diverse immune cells for anticancer therapy: beyond immune checkpoint inhibitors

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: 210, P. 104702 - 104702

Published: March 22, 2025

Although immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, primary resistance and acquired continue to limit their efficacy for many patients. To address enhance the anti-tumor activity within tumor microenvironment (TIME), numerous therapeutic strategies targeting both innate adaptive cells emerged. These include combination therapies with ICIs, chimeric antigen receptor T-cell (CAR-T), macrophages (CAR-Ms) or natural killer cell (CAR-NK) therapy, colony stimulating factor 1 (CSF1R) inhibitors, dendritic (DC) vaccines, toll-like (TLR) agonists, cytokine therapies, chemokine inhibition. approaches underscore significant potential of TIME in treatment. This article provides a comprehensive up-to-date review mechanisms action various TIME, as well each type, aiming deepen understanding potential.

Language: Английский

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A silence catalyst: CCL5-mediated intercellular communication in cancer

Archives of Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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A novel perspective on bone tumors: advances in organoid research

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 8, 2025

Bone tumor organoids are three-dimensional cell culture models derived from patient tissues or cells, capable of highly replicating the growth patterns and interactions bone tumors in vitro . Current treatments for hindered by challenges such as drug resistance, recurrence, metastasis. Organoids enhance physiological relevance models, thereby improving treatment precision overcoming limitations current therapeutic approaches. Organoid technology has made preliminary applications research, including primary tumors, metastatic marrow-derived tumors. This review will explore establishment organoids, summarize their prospects various diseases, discuss integration with emerging technologies. Additionally, future directions organoid research be discussed. In future, expected to promote further development medicine.

Language: Английский

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The immune response of upper and lower airway epithelial cells to Aspergillus fumigatus and Candida albicans-derived β-glucan in Th17 type cytokine environment

Archives of Microbiology, Journal Year: 2025, Volume and Issue: 207(4)

Published: Feb. 24, 2025

Language: Английский

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Establishment of patient-derived 3D in vitro models of sarcomas: literature review and guidelines on behalf of the FORTRESS working group

Neoplasia, Journal Year: 2025, Volume and Issue: 65, P. 101171 - 101171

Published: May 3, 2025

Language: Английский

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