Single-cell transcriptomic analysis reveals dynamic changes in the liver microenvironment during colorectal cancer metastatic progression DOI Creative Commons
Yue Jiang,

Guojie Long,

Xiaoming Huang

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 16, 2025

Metastasis is a leading cause of cancer-related deaths, with the liver being most frequent site metastasis in colorectal cancer. Previous studies have predominantly focused on influence primary tumor itself metastasis, relatively limited research examining changes within target organs. Using an orthotopic mouse model cancer, single-cell sequencing was employed to profile transcriptomic landscape pre-metastatic and metastatic livers. The analysis identifying cellular molecular hepatic microenvironment, particular emphasis inflammatory pathways immune cell populations. A neutrophil subpopulation high Prok2 expression identified, showing elevated levels liver. Increased infiltration Prok2⁺ neutrophils correlated poor prognosis cancer patients. In niche (MN), these showed App Cd274 (PD-L1) expression, suppressing macrophage phagocytosis promoting T-cell exhaustion. infiltrated both macro-metastatic environments, potentially driving immunosuppression through inhibition Targeting could represent novel therapeutic strategy for preventing

Language: Английский

Targeting cytokine and chemokine signaling pathways for cancer therapy DOI Creative Commons
Ming Yi, Tianye Li,

Mengke Niu

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: July 22, 2024

Abstract Cytokines are critical in regulating immune responses and cellular behavior, playing dual roles both normal physiology the pathology of diseases such as cancer. These molecules, including interleukins, interferons, tumor necrosis factors, chemokines, growth factors like TGF-β, VEGF, EGF, can promote or inhibit growth, influence microenvironment, impact efficacy cancer treatments. Recent advances targeting these pathways have shown promising therapeutic potential, offering new strategies to modulate system, progression, overcome resistance conventional therapies. In this review, we summarized current understanding implications cytokine chemokine signaling By exploring molecules biology response, highlighted development novel agents aimed at modulating combat The review elaborated on nature cytokines promoters suppressors tumorigenesis, depending context, discussed challenges opportunities presents for intervention. We also examined latest advancements targeted therapies, monoclonal antibodies, bispecific receptor inhibitors, fusion proteins, engineered variants, their metastasis, microenvironment. Additionally, evaluated potential combining therapies with other treatment modalities improve patient outcomes. Besides, focused ongoing research clinical trials that pivotal advancing our application cytokine- chemokine-targeted patients.

Language: Английский

Citations

67
Insights into IL-6/JAK/STAT3 Signaling in the Tumor Microenvironment: Implications for Cancer Therapy DOI

Win Lwin Thuya,

Yang Cao,

Paul Chi-Lui Ho

et al.

Cytokine & Growth Factor Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

5
Interleukin-6 (IL-6)-associated tumor microenvironment remodelling and cancer immunotherapy DOI
Songsong Wu,

Zhumin Cao,

Ruinan Lu

et al.

Cytokine & Growth Factor Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

2
Inflammation in cancer: therapeutic opportunities from new insights DOI Creative Commons
Yifei Xie, Fangfang Liu, Yunfei Wu

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 24, 2025

As one part of the innate immune response to external stimuli, chronic inflammation increases risk various cancers, and tumor-promoting is considered enabling characteristics cancer development. Recently, there has been growing evidence on role anti-inflammation therapy in prevention treatment. And researchers have already achieved several noteworthy outcomes. In review, we explored underlying mechanisms by which affects occurrence development cancer. The pro- or anti-tumor effects these inflammatory factors such as interleukin, interferon, chemokine, inflammasome, extracellular matrix are discussed. Since FDA-approved drugs like aspirin show obvious effects, unique advantages due their relatively fewer side with long-term use compared chemotherapy drugs. make them promising candidates for chemoprevention. Overall, this review discusses molecules carcinogenesis new molecules-directed therapeutic opportunities, ranging from cytokine inhibitors/agonists, inflammasome inhibitors, some inhibitors that expected be applied clinical practice, well recent discoveries effect non-steroidal anti-inflammatory steroidal disadvantages application chemoprevention also

Language: Английский

Citations

2
Crosstalk of pyroptosis and cytokine in the tumor microenvironment: from mechanisms to clinical implication DOI Creative Commons
Hua Wang, Tao Wang, Shuxiang Yan

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Nov. 30, 2024

In the realm of cancer research, tumor microenvironment (TME) plays a crucial role in initiation and progression, shaped by complex interactions between cells surrounding non-cancerous cells. Cytokines, as essential immunomodulatory agents, are secreted various cellular constituents within TME, including immune cells, cancer-associated fibroblasts, themselves. These cytokines facilitate intricate communication networks that significantly influence initiation, metastasis, suppression. Pyroptosis contributes to TME remodeling promoting release pro-inflammatory sustaining chronic inflammation, impacting processes such escape angiogenesis. However, challenges remain due interplay among cytokines, pyroptosis, along with dual effects pyroptosis on progression therapy-related complications like cytokine syndrome. Unraveling these complexities could strategies balance inflammatory responses while minimizing tissue damage during therapy. This review delves into crosstalk elucidating their contribution metastasis. By synthesizing emerging therapeutic targets innovative technologies concerning this aims provide novel insights enhance treatment outcomes for patients.

Language: Английский

Citations

12
Atherosclerosis and the Bidirectional Relationship Between Cancer and Cardiovascular Disease: From Bench to Bedside, Part 2 Management DOI Open Access

Giuseppina Gallucci,

Mario Larocca, Alessandro Navazio

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(1), P. 334 - 334

Published: Jan. 2, 2025

The first part of this review highlighted the evolving landscape atherosclerosis, noting emerging cardiometabolic risk factors, growing impact exposomes, and social determinants health. prominent role atherosclerosis in bidirectional relationship between cardiovascular disease cancer was also discussed. In second part, we examine complex interplay multimorbid cardio-oncologic patients, harmful environments that lend a “syndemic” nature to these chronic diseases. We summarize management strategies targeting disordered factors mitigate explore molecular mechanisms enabling more tailored therapies. Importantly, emphasize early interception through multifactorial interventions detect subclinical signs (via biomarkers imaging) treat modifiable prevent clinical events. A concerted preventive effort—referred by some as “preventome”—is essential reduce burden atherosclerosis-driven diseases, shifting from mere proactive promotion “chronic health”.

Language: Английский

Citations

1
Ferroptosis meets inflammation: a new frontier in cancer therapy DOI
Hu Liu,

Hui Xue,

Qian Guo

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217696 - 217696

Published: April 1, 2025

Language: Английский

Citations

1
Advances in Melanoma: From Genetic Insights to Therapeutic Innovations DOI Creative Commons
Fernando Valdez-Salazar,

Luis Alberto Jiménez-Del Río,

Jorge Ramón Padilla‐Gutiérrez

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1851 - 1851

Published: Aug. 14, 2024

Advances in melanoma research have unveiled critical insights into its genetic and molecular landscape, leading to significant therapeutic innovations. This review explores the intricate interplay between alterations, such as mutations BRAF, NRAS, KIT, pathogenesis. The MAPK PI3K/Akt/mTOR signaling pathways are highlighted for their roles tumor growth resistance mechanisms. Additionally, this delves impact of epigenetic modifications, including DNA methylation histone changes, on progression. microenvironment, characterized by immune cells, stromal soluble factors, plays a pivotal role modulating behavior treatment responses. Emerging technologies like single-cell sequencing, CRISPR-Cas9, AI-driven diagnostics transforming research, offering precise personalized approaches treatment. Immunotherapy, particularly checkpoint inhibitors mRNA vaccines, has revolutionized therapy enhancing body’s response. Despite these advances, mechanisms remain challenge, underscoring need combined therapies ongoing achieve durable comprehensive overview aims highlight current state transformative impacts advancements clinical practice.

Language: Английский

Citations

8
Advances in targeting tumor microenvironment for immunotherapy DOI Creative Commons

Lugang Wang,

Liubo Zhang,

Zhen Zhang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 3, 2024

The tumor microenvironment (TME) provides essential conditions for the occurrence, invasion, and spread of cancer cells. Initial research has uncovered immunosuppressive properties TME, which include low oxygen levels (hypoxia), acidic (low pH), increased interstitial pressure, heightened permeability vasculature, an inflammatory microenvironment. presence various components leads to immune evasion affects immunotherapy efficacy. This indicates potential value targeting TME in immunotherapy. Therefore, remodeling become effective method enhancing host responses against tumors. In this study, we elaborate on characteristics composition how it weakens surveillance summarize targeted therapeutic strategies regulating TME.

Language: Английский

Citations

8
Navigating the Cytokine Seas: Targeting Cytokine Signaling Pathways in Cancer Therapy DOI Open Access

Noyko Stanilov,

Tsvetelina Velikova, Spaska Stanilova

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 1009 - 1009

Published: Jan. 13, 2024

Cancer remains one of the leading causes morbidity and mortality worldwide, necessitating continuous efforts to develop effective therapeutic strategies. Over years, advancements in our understanding complex interplay between immune system cancer cells have led development immunotherapies that revolutionize treatment. Cytokines, as key regulators response, are involved both initiation progression by affecting inflammation manipulating multiple intracellular signaling pathways regulate cell growth, proliferation, migration. inflammation, emerged promising candidates for therapy. This review article aims provide an overview significance cytokines therapy highlighting importance targeting cytokine a potential approach.

Language: Английский

Citations

7