Fabrication of a Spiral Microfluidic Chip for the Mass Production of Lipid Nanoparticles Using Laser Engraving DOI Creative Commons

Inseong Choi,

Mincheol Cho,

Min Song

et al.

Micromachines, Journal Year: 2025, Volume and Issue: 16(5), P. 501 - 501

Published: April 25, 2025

A spiral microfluidic chip (SMC) and multi-spiral (MSMC) for lipid nanoparticle (LNP) production were fabricated using a CO2 laser engraving method, perfluoropolyether (PFPE) poly(ethylene glycol) diacrylate as photopolymerizable base materials. The SMC includes microchannel that enables rapid fluid mixing, thereby facilitating the of small uniform LNPs with size 72.82 ± 24.14 nm PDI 0.111 0.011. MSMC integrates multiple parallel structures, which high-throughput LNP without compromising quality achieves maximum capacity 960 mL per hour. fabrication technology has potential applications in pharmaceutical field due to ease fabrication, simplicity cost-effectiveness process, ability produce high-quality LNPs.

Language: Английский

Novel Strategies in Breast Cancer Management: from Treatment to Long-term Remission DOI

S Habibi,

Shabbou Bahramian,

Saeedeh Zare Jalise

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104715 - 104715

Published: April 1, 2025

Language: Английский

Citations

2
Autologous nanovaccine repolarizes tumor-associated macrophages to M1 phenotype inducing PANoptosis for lung cancer immunotherapy DOI
Chi Zhang, Yukun Chen, Zhongyang Yu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 514, P. 163201 - 163201

Published: May 3, 2025

Language: Английский

Citations

0
A review of advances in in vitro RNA preparation by ssRNAP DOI

Yuan Shen,

Dong-Qi Yang,

Yuan Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 304, P. 141002 - 141002

Published: Feb. 12, 2025

Language: Английский

Citations

0
Fabrication of a Spiral Microfluidic Chip for the Mass Production of Lipid Nanoparticles Using Laser Engraving DOI Creative Commons

Inseong Choi,

Mincheol Cho,

Min Song

et al.

Micromachines, Journal Year: 2025, Volume and Issue: 16(5), P. 501 - 501

Published: April 25, 2025

A spiral microfluidic chip (SMC) and multi-spiral (MSMC) for lipid nanoparticle (LNP) production were fabricated using a CO2 laser engraving method, perfluoropolyether (PFPE) poly(ethylene glycol) diacrylate as photopolymerizable base materials. The SMC includes microchannel that enables rapid fluid mixing, thereby facilitating the of small uniform LNPs with size 72.82 ± 24.14 nm PDI 0.111 0.011. MSMC integrates multiple parallel structures, which high-throughput LNP without compromising quality achieves maximum capacity 960 mL per hour. fabrication technology has potential applications in pharmaceutical field due to ease fabrication, simplicity cost-effectiveness process, ability produce high-quality LNPs.

Language: Английский

Citations

0