From prevention to management: Exploring the impact of diet on multiple sclerosis DOI Creative Commons

Dalya Koukach,

Maryam Aljumaily,

Noora Al-Attiyah

et al.

Translational Neuroscience, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 1, 2025

Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system characterized by neuroinflammation and progressive neurodegeneration. Growing evidence suggests that dietary interventions may influence MS progression symptom management modulating inflammation, oxidative stress, gut microbiota composition. This narrative review examines effects Mediterranean, plant-based, ketogenic, Wahls, Swank, intermittent fasting, gluten-free diets, alongside key nutrients such as omega-3 fatty acids, vitamin D, polyphenols, antioxidants. Among these, Mediterranean plant-based diets have shown most consistent benefits, including reductions in fatigue, improved quality life, modulation inflammatory markers. The Wahls Swank show promise but are primarily supported studies from their respective research groups, raising concerns about long-term adherence nutritional adequacy. ketogenic diet fasting yielded mixed findings, with some suggesting benefits for fatigue neuroprotection, while others highlight potential metabolic risks. supplementation lack robust evidence, inconsistent findings across studies. Additionally, ultra-processed foods high saturated fats been associated increased inflammation greater severity. Despite promising limitations small sample sizes, short follow-up durations, study design inconsistencies prevent definitive conclusions. Future should prioritize large-scale, randomized controlled trials to establish efficacy, safety, sustainability management. Mechanistic standardized protocols also needed better understand role control.

Language: Английский

Ketogenic diet in children and adolescents: The effects on growth and nutritional status DOI Creative Commons
Antonio Corsello, Chiara Maria Trovato, Elisabetta Di Profio

et al.

Pharmacological Research, Journal Year: 2023, Volume and Issue: 191, P. 106780 - 106780

Published: April 23, 2023

The ketogenic diet is known to be a possible adjuvant treatment in several medical conditions, such as patients with severe or drug-resistant forms of epilepsy. Its use has recently been increasing among adolescents and young adults due its supposed weight-loss effect, mediated by lipolysis lowered insulin levels. However, there are still no precise indications on the diets pediatric age for weight loss. This approach also proposed other types disorder inherited metabolic disorders, Prader-Willi syndrome, some specific cancers. Due unbalanced ratio lipids, carbohydrates proteins, clinical evaluation side effects strict growth nutritional status essential all following long-term restrictive one. prophylactic micronutrients supplementation should considered before starting any diet. Lastly, while sufficient literature short-term diets, their impact not yet fully understood, especially when started age.

Language: Английский

Citations

14
The Compelling Role of Brain‐Derived Neurotrophic Factor Signaling in Multiple Sclerosis: Role of BDNF Activators DOI Creative Commons
Hayder M. Al‐kuraishy, Ghassan M. Sulaiman, Hamdoon A. Mohammed

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(12)

Published: Dec. 1, 2024

Brain-derived neurotrophic factor (BDNF) is a neurotrophin, acting as signal and neuromodulator in the central nervous system (CNS). BDNF synthesized from its precursor proBDNF within CNS peripheral tissues. Through activation of NTRK2/TRKB (neurotrophic receptor tyrosine kinase 2), promotes neuronal survival, synaptic plasticity, growth, whereas it inhibits microglial release pro-inflammatory cytokines. dysregulated different neurodegenerative diseases depressions. However, there major controversy concerning levels stages multiple sclerosis (MS). Therefore, this review discusses potential role signaling MS, how modulators affect pathogenesis outcomes disease.

Language: Английский

Citations

5
A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity DOI Creative Commons
Margaret Alexander, Vaibhav Upadhyay,

Rachel Rock

et al.

Cell Reports, Journal Year: 2024, Volume and Issue: 43(11), P. 114891 - 114891

Published: Nov. 1, 2024

Diet can protect from autoimmune disease; however, whether diet acts via the host and/or microbiome remains unclear. Here, we use a ketogenic (KD) as model to dissect these complex interactions. A KD rescued experimental encephalomyelitis (EAE) mouse of multiple sclerosis in microbiota-dependent fashion. Dietary supplementation with single KD-dependent metabolite (β-hydroxybutyrate [βHB]) EAE, whereas transgenic mice unable produce βHB intestine developed more severe disease. Transplantation βHB-shaped gut microbiota was protective. Lactobacillus sequence variants were associated decreased T helper 17 cell activation vitro. Finally, isolated an L. murinus strain that protected which phenocopied by enriched supplementation, indole lactate. Thus, alters immunomodulatory potential shifting metabolism, emphasizing utility taking integrative approach study diet-host-microbiome

Language: Английский

Citations

5
Multiple sclerosis and circadian rhythms: Can diet act as a treatment? DOI Creative Commons
Olga Pivovarova‐Ramich, Hanna Zimmermann, Friedemann Paul

et al.

Acta Physiologica, Journal Year: 2023, Volume and Issue: 237(4)

Published: Jan. 26, 2023

Multiple sclerosis (MS) is an autoimmune inflammatory and neurodegenerative disease of the central nervous system (CNS) with increasing incidence prevalence. MS associated metabolic disturbances that, as preliminary human animal data suggest, might be mediated by disruption circadian rhythmicity. Nutrition habits can influence risk for MS, dietary interventions may effective in modulating course. Chronotherapeutic approaches such time-restricted eating (TRE) benefit people stabilizing clock restoring immunological rhythms, thus potentially counteracting progression. This review provides a summary selected studies on intervention their including gene variations, hormones, retino-hypothalamic tract changes. Furthermore, we present that reported diurnal variations which result from disruption. And lastly, suggest how chrononutritive like TRE counteract activity.

Language: Английский

Citations

10
Exploring the impact of ketogenic diet on multiple sclerosis: obesity, anxiety, depression, and the glutamate system DOI Creative Commons
José Enrique de la Rubia Ortí, María Cuerda‐Ballester, Claudia Emmanuela Sanchis-Sanchis

et al.

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: Aug. 25, 2023

Multiple sclerosis (MS) is a neurodegenerative disorder. Individuals with MS frequently present symptoms such as functional disability, obesity, and anxiety depression. Axonal demyelination can be observed implies alterations in mitochondrial activity increased inflammation associated disruptions glutamate neurotransmitter activity. In this context, the ketogenic diet (KD), which promotes production of ketone bodies blood [mainly β-hydroxybutyrate (βHB)], non-pharmacological therapeutic alternative that has shown promising results peripheral obesity reduction central reduction. However, association type emotional through modulation individuals remains unknown.To provide an update on topic discuss potential impact KD depression subjects MS.The main findings suggest KD, source blood, improves by reducing insulin resistance dyslipidemia, promoting (particularly increase interleukins IL-1β, IL-6, IL-17). This improvement would imply decrease extrasynaptic activity, been linked to disability presence disorders

Language: Английский

Citations

10
Association of Higher Mediterranean Diet Adherence With Lower Prevalence of Disability and Symptom Severity, Depression, Anxiety, Stress, Sleep Quality, Cognitive Impairment, and Physical Inactivity in Older Adults With Multiple Sclerosis DOI

Christina Tryfonos,

Eleni Pavlidou, Theofanis Vorvolakos

et al.

Journal of Geriatric Psychiatry and Neurology, Journal Year: 2023, Volume and Issue: 37(4), P. 318 - 331

Published: Nov. 29, 2023

A good nutritional status and healthy diets may decelerate disease disability symptom severity quality of life peoples with multiple sclerosis (MS). Mediterranean diet (MD) can prevent several chronic diseases, including neurodegenerative disease. This is an observational, cross-sectional study on 279 older adults MS, aiming to investigate the effects MD against aspects mental health. Qualified questionnaires were used assess severity, depression, anxiety, stress, sleep quality, cognitive status, physical activity, adherence. Multivariate analysis showed that enhanced adherence was independently associated lower prevalence ( P = .0019), depression .0201), anxiety .0287), perceived stress .0021), inadequate .0033), impairment .0018) inactivity .0028). Adopting ameliorate health disturbances in MS. Future public policies should inform MS for favorable impacts improving comorbidities.

Language: Английский

Citations

10
Nutritional interventional studies in patients with multiple sclerosis: a scoping review of the current clinical evidence DOI

Christina Tryfonos,

Maria Chrysafi,

Κonstantinos Vadikolias

et al.

Journal of Neurology, Journal Year: 2024, Volume and Issue: 271(4), P. 1536 - 1570

Published: Jan. 4, 2024

Language: Английский

Citations

4
The role of the “gut microbiota-mitochondria” crosstalk in the pathogenesis of multiple sclerosis DOI Creative Commons
Huan Tian,

Dunbing Huang,

Jiaqi Wang

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: April 29, 2024

Multiple Sclerosis (MS) is a neurologic autoimmune disease whose exact pathophysiologic mechanisms remain to be elucidated. Recent studies have shown that the onset and progression of MS are associated with dysbiosis gut microbiota. Similarly, large body evidence suggests mitochondrial dysfunction may also significant impact on development MS. Endosymbiotic theory has found human mitochondria microbial in origin share similar biological characteristics Therefore, microbiota function crosstalk relevant However, relationship between not fully understood. by synthesizing previous literature, this paper focuses changes metabolite composition possible MS, provide new therapeutic approaches for prevention or reduction based crosstalk.

Language: Английский

Citations

4
Consensus recommendations on multiple sclerosis management in Australia and New Zealand: part 2 DOI Open Access
Jessica Shipley, James Beharry, Wei Zhen Yeh

et al.

The Medical Journal of Australia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 9, 2025

Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system with rapidly evolving treatment options strategies. An iterative modified Delphi process was used to develop 80 consensus recommendations for management MS in Australia New Zealand. Part 1 these guidelines includes related selection initial disease-modifying therapy (DMT) MS, assessments before commencing DMT, monitoring activity on switching discontinuing DMT. This article, 2, covers risk mitigation during managing DMT special situations (including pregnancy, postpartum, breastfeeding, active infection including COVID-19, malignancy), general lifestyle measures acute relapses, symptomatic treatments. Together 1, this statement provides practical guidance clinicians involved care adults (≥ 18 years old) A safe, effective comprehensive approach crucial improving long term outcomes quality life individuals affected by MS.

Language: Английский

Citations

0
Endogenous Ketone Bodies Are Associated with Metabolic Vulnerability and Disability in Multiple Sclerosis DOI Open Access
Taylor R Wicks, Irina Shalaurova, Anna Wolska

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 640 - 640

Published: Feb. 11, 2025

Purpose: Ketone bodies could be useful biomarkers in multiple sclerosis (MS) because the pathophysiological processes underlying MS disease progression induce metabolic stress. The purpose was to assess relationships of ketone with metabolic, inflammatory, and oxidative stress MS. Methods: Blood samples neurological assessments were obtained from 153 healthy controls (HC), 187 relapsing-remitting (RRMS), 91 progressive (PMS) patients. AcAc, BHB, acetone measured using proton nuclear magnetic resonance spectroscopy. Indices inflammatory vulnerability (IVX), malnutrition (MMX), (MVX) computed NMR profiles. Cholesterol, apolipoprotein, lipid peroxidation, antioxidant profiles obtained. Regression analysis adjusted for age, sex, body mass index, HC, RRMS, or PMS status. Results: AcAc BHB levels greater compared HC. positively associated disability on Severity Scale ambulation time. IVX, MMX, MVX. MMX negatively IVX Total concentration amino acids alanine, valine, leucine. Conclusions: are vulnerability, ambulatory measures

Language: Английский

Citations

0