Temporal dynamics of neurovascular unit changes following blood-brain barrier opening in the putamen of non-human primates DOI Creative Commons
Tiziano Balzano, José A. Pineda‐Pardo, Noelia Esteban‐Garcia

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 377, P. 116 - 126

Published: Nov. 18, 2024

Low-intensity focused ultrasound (LIFU) combined with intravenously circulating microbubbles has recently emerged as a novel approach for increasing delivery through the blood-brain barrier (BBB). This technique safely and transiently enables therapeutic agents to overcome BBB, which typically poses significant obstacle treatment of brain disorders. However, full impact LIFU on entire neurovascular unit (NVU), well mechanisms factors involved in restoring BBB integrity still require further elucidation. We conducted immunohistochemical analyses putamen non-human primates monitor changes over time [immediately post-treatment (3 h) at 7- 30-days post-BBB opening] vascular, glial, immune cells. Additionally, we examined dynamic interactions among these elements their role restorative process level. A mild inflammatory response primarily involving microglia, astrocytes, T- B-lymphocytes was observed treated acutely after opening. These cells, recruited vascular changes, stimulate upregulation PDGFRβ, pericyte-specific marker, VEGF-A, pro-angiogenic factor. associated sprouting by 7 days Importantly, no notable long-term alterations were NVU 30 results offer evidence regarding efficacy safety achieving opening primate brain, indicating that nearly all revert baseline within post-treatment. also suggests angiogenesis may play an important

Language: Английский

Crossing the blood–brain barrier: emerging therapeutic strategies for neurological disease DOI

Josephine H Pedder,

Adam M. Sonabend,

Michael D Cearns

et al.

The Lancet Neurology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

4
Impact of Peripheral Inflammation on Blood–Brain Barrier Dysfunction and Its Role in Neurodegenerative Diseases DOI Open Access
Ana Isabel Beltrán-Velasco, Vicente Javier Clemente‐Suárez

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2440 - 2440

Published: March 9, 2025

The blood–brain barrier (BBB) is essential for maintaining brain homeostasis by regulating molecular exchange between the systemic circulation and central nervous system. However, its dysfunction, often driven peripheral inflammatory processes, has been increasingly linked to development progression of neurodegenerative diseases such as Alzheimer’s Parkinson’s. Emerging evidence suggests that gut–brain axis plays a key role in BBB integrity, with intestinal dysbiosis chronic inflammation contributing disruption through immune metabolic pathways. Furthermore, selective vulnerability specific regions dysfunction appears be influenced regional differences vascularization, activity, permeability, making certain areas more susceptible processes. This review explored mechanisms linking inflammation, gut microbiota, emphasizing their neurodegeneration. A comprehensive literature was conducted using Web Science, PubMed, Scopus, Wiley, ScienceDirect, Medline, covering publications from 2015 2025. findings highlight complex interplay microbiota-derived metabolites, signaling, underscoring need targeted interventions microbiome modulation, anti-inflammatory therapies, advanced drug delivery systems. heterogeneity across different necessitates region-specific therapeutic strategies. Despite advancements, critical knowledge gaps persist regarding precise underlying dysfunction. Future research should leverage cutting-edge methodologies single-cell transcriptomics organ-on-chip models translate preclinical into effective clinical applications. Addressing these challenges will crucial developing personalized approaches mitigate impact diseases.

Language: Английский

Citations

1
Postencephalitic Parkinsonism: Unique Pathological and Clinical Features—Preliminary Data DOI Creative Commons

Sabrina Strobel,

Jeswinder Sian‐Hülsmann, Dennis Tappe

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(18), P. 1511 - 1511

Published: Sept. 10, 2024

Postencephalitic parkinsonism (PEP) is suggested to show a virus-induced pathology, which different from classical idiopathic Parkinson's disease (PD) as there no α-synuclein/Lewy body pathology. However, PEP shows typical clinical representation of motor disturbances. In addition, compared PD, iron-induced The aim this preliminary study was compare with PD regarding using histochemistry methods on paraffin-embedded post-mortem brain tissue. the group, iron not seen, except for one case sparse perivascular depositions. Rather, offers pathology related tau-protein/neurofibrillary tangles, mild moderate memory deficits only. It assumed that due immunological dysfunctions causing (neuro)inflammation-induced neuronal network disturbances events trigger parkinsonism. absence deposits implies cannot be treated chelators. therapy L-Dopa also an option, only leads initial slight improvement in symptoms isolated cases.

Language: Английский

Citations

2
Temporal dynamics of neurovascular unit changes following blood-brain barrier opening in the putamen of non-human primates DOI Creative Commons
Tiziano Balzano, José A. Pineda‐Pardo, Noelia Esteban‐Garcia

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 377, P. 116 - 126

Published: Nov. 18, 2024

Low-intensity focused ultrasound (LIFU) combined with intravenously circulating microbubbles has recently emerged as a novel approach for increasing delivery through the blood-brain barrier (BBB). This technique safely and transiently enables therapeutic agents to overcome BBB, which typically poses significant obstacle treatment of brain disorders. However, full impact LIFU on entire neurovascular unit (NVU), well mechanisms factors involved in restoring BBB integrity still require further elucidation. We conducted immunohistochemical analyses putamen non-human primates monitor changes over time [immediately post-treatment (3 h) at 7- 30-days post-BBB opening] vascular, glial, immune cells. Additionally, we examined dynamic interactions among these elements their role restorative process level. A mild inflammatory response primarily involving microglia, astrocytes, T- B-lymphocytes was observed treated acutely after opening. These cells, recruited vascular changes, stimulate upregulation PDGFRβ, pericyte-specific marker, VEGF-A, pro-angiogenic factor. associated sprouting by 7 days Importantly, no notable long-term alterations were NVU 30 results offer evidence regarding efficacy safety achieving opening primate brain, indicating that nearly all revert baseline within post-treatment. also suggests angiogenesis may play an important

Language: Английский

Citations

2