Physical Exercise: A Promising Treatment Against Organ Fibrosis

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(1), P. 343 - 343

Published: Jan. 2, 2025

Fibrosis represents a terminal pathological manifestation encountered in numerous chronic diseases. The process involves the persistent infiltration of inflammatory cells, transdifferentiation fibroblasts into myofibroblasts, and excessive deposition extracellular matrix (ECM) within damaged tissues, all which are characteristic features organ fibrosis. Extensive documentation exists on fibrosis occurrence vital organs such as liver, heart, lungs, kidneys, skeletal muscles, elucidating its underlying mechanisms. Regular exercise is known to confer health benefits through anti-inflammatory, antioxidant, anti-aging effects. Notably, exerts anti-fibrotic effects by modulating multiple pathways, including transforming growth factor-β1/small mother decapentaplegic protein (TGF-β1/Samd), Wnt/β-catenin, nuclear factor kappa-B (NF-kB), reactive oxygen species (ROS), microRNAs (miR-126, miR-29a, miR-101a), exerkine (FGF21, irisin, FSTL1, CHI3L1). Therefore, this paper aims review specific role molecular mechanisms potential intervention ameliorate

Language: Английский

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Armeniacae semen amarum: a review on its botany, phytochemistry, pharmacology, clinical application, toxicology and pharmacokinetics

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 23, 2024

Armeniacae semen amarum —seeds of Prunus armeniaca L. (Rosaceae) (ASA), also known as Kuxingren in Chinese, is a traditional Chinese herbal drug commonly used for lung disease and intestinal disorders. It has long been to treat coughs asthma, well lubricate the colon reduce constipation. ASA refers dried ripe seed diverse species Rosaceae contains variety phytochemical components, including glycosides, organic acids, amino flavonoids, terpenes, phytosterols, phenylpropanoids, other components. Extensive data shows that exhibits various pharmacological activities, such anticancer activity, anti-oxidation, antimicrobial anti-inflammation, protection cardiovascular, neural, respiratory digestive systems, antidiabetic effects, liver kidney, activities. In clinical practice, can be single or combination with medicines, forming ASA-containing formulas, afflictions. However, it important consider potential adverse reactions pharmacokinetic properties during its use. Overall, bioactive diversified actions potent efficacies, promising merits in-depth study on functional mechanisms facilitate application.

Language: Английский

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Revealing Structure and Localization of Steroid Regioisomers through Predictive Fragmentation Patterns in Mass Spectrometry Imaging

Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(48), P. 17843 - 17850

Published: Nov. 17, 2023

Identifying and mapping steroids in tissues can provide opportunities for biomarker discovery, the interrogation of disease progression, new therapeutics. Although separation coupled to mass spectrometry (MS) has emerged as a powerful tool studying steroids, imaging annotating steroid isomers remains challenging. Herein, we present method based on fragmentation silver-cationized tandem MS, which produces distinctive consistent patterns conferring confidence annotation at regioisomeric level without using prior derivatization, separation, or instrumental modification. In addition predicting structure with isomeric specificity, is simple, flexible, inexpensive, suggesting that wider community will easily adapt it. We demonstrate utility our approach by visualizing isomer distributions mouse brain tissue silver-doped pneumatically assisted nanospray desorption electrospray ionization imaging.

Language: Английский

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Investigation of the ameliorative effects of amygdalin against arsenic trioxide-induced cardiac toxicity in rat

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 128, P. 106795 - 106795

Published: April 8, 2025

Language: Английский

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Aerobic Exercise Activates AMPK/PGC-1α Pathway, Inhibits Cardiomyocyte Apoptosis Improves Mitochondrial and Infarcted Heart Function

Doklady Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 518(1), P. 420 - 428

Published: Aug. 28, 2024

Language: Английский

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