The Personal Health Applications of Machine Learning Techniques in the Internet of Behaviors

Sustainability, Journal Year: 2023, Volume and Issue: 15(16), P. 12406 - 12406

Published: Aug. 15, 2023

With the swift pace of development artificial intelligence (AI) in diverse spheres, medical and healthcare fields are utilizing machine learning (ML) methodologies numerous inventive ways. ML techniques have outstripped formerly state-of-the-art practices, yielding faster more precise outcomes. Healthcare practitioners increasingly drawn to this technology their initiatives relating Internet Behavior (IoB). This area research scrutinizes rationales, approaches, timing human adoption, encompassing domains Things (IoT), behavioral science, edge analytics. The significance applications based on IoB stems from its ability analyze interpret copious amounts complex data instantly, providing innovative perspectives that can enhance outcomes boost efficiency IoB-based procedures thus aid diagnoses, treatment protocols, clinical decision making. As a result inadequacy thorough inquiry into employment ML-based approaches context using for applications, we conducted study subject matter, introducing novel taxonomy underscores need employ each method distinctively. objective mind, classified cutting-edge solutions challenges five categories, which convolutional neural networks (CNNs), recurrent (RNNs), deep (DNNs), multilayer perceptions (MLPs), hybrid methods. In order delve deeper, systematic literature review (SLR) examined critical factors, such as primary concept, benefits, drawbacks, simulation environment, datasets. Subsequently, highlighted pioneering studies issues. Moreover, several related implementation medicine been tackled, thereby gradually fostering further endeavors health studies. Our findings indicated Tensorflow was most commonly utilized setting, accounting 24% proposed by researchers. Additionally, accuracy deemed be crucial parameter majority papers.

Language: Английский

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Structural analysis, reactivity descriptors (HOMO-LUMO, ELF, NBO), effect of polar (DMSO, EtOH, H2O) solvation, and libido-enhancing potential of resveratrol by molecular docking

Chemical Physics Impact, Journal Year: 2023, Volume and Issue: 7, P. 100296 - 100296

Published: Aug. 30, 2023

The profound impact of health challenges related to libido, encompassing sexual dysfunction, hormonal imbalances, relationship difficulties, stress, anxiety, depression, and the effects certain medical conditions or medications, calls for urgent mitigative measures. As a result, this study meticulously explores compound Resveratrol (Res) uncover its substantial properties concerning libido enhancement. was optimized using DFT/ωB97XD/6-311G++(d, p) basis set in different solvents, namely DMSO (dimethyl sulfoxide), ethanol, water. Notably, geometry investigation reveals that structural bond variations can be attributed factors such as solvent polarity, screening effects, hydrogen bonding, solvation energy, conformational preferences. Substantially, Frontier Molecular Orbital (FMO) analysis explored HOMO values resulting 7.59198eV, 7.5514eV, 7.59687eV RES_DMSO, RES_EtOH, RES_H2O, respectively. Correspondingly, their LUMO were found 7.5955eV, 7.5648eV, 7.5982eV, leading respective band gaps 0.0035eV, 0.0133eV, 0.0014eV. Remarkably, RES_H2O displayed smallest energy gap (0.0014eV) among interacting compounds, indicating increased conductivity sensitivity. Furthermore, natural orbital revealed had highest permutation three complexes (376.5 kcal/mol 371.79 378.77 RES_H2O), stronger interaction between donor acceptor orbitals. Finally, molecular docking studies unveiled notable difference binding affinity, with RES exhibiting greater affinity 1UDT at -8.1 compared 1UDU, which demonstrated -6.6 kcal/mol. Thus, has potential reverse erectile dysfunction improve by inhibiting activities phosphodiesterase (1UDT 1UDU), ultimately promoting vasodilatory signals from cGMP smooth muscles penis, enhanced erection. These groundbreaking findings offer promising prospects development new effective drugs combat various conditions.

Language: Английский

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Elucidation of collagen amino acid interactions with metals (B, Ni) encapsulated graphene/PEDOT material: Insight from DFT calculations and MD simulation

Journal of Molecular Liquids, Journal Year: 2023, Volume and Issue: 390, P. 122950 - 122950

Published: Aug. 31, 2023

Language: Английский

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Green synthesis of Ag and Cu-doped Bismuth oxide nanoparticles: Revealing synergistic antimicrobial and selective cytotoxic potentials for biomedical advancements

Journal of Trace Elements in Medicine and Biology, Journal Year: 2023, Volume and Issue: 81, P. 127325 - 127325

Published: Oct. 20, 2023

Language: Английский

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Mood and microbes: a comprehensive review of intestinal microbiota’s impact on depression

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 9, 2024

Depression is considered a multifaceted and intricate mental disorder of growing concern due to its significant impact on global health issues. The human gut microbiota, also known as the “second brain,” has an important role in CNS by regulating it through chemical, immunological, hormonal, neurological processes. Various studies have found bidirectional link between brain gut, emphasizing onset depression therapies. biological molecular processes underlying microbiota are required, association may represent novel study. However, profound insights into stratification diversity still uncommon. This article investigates emerging evidence bacterial relationship brain’s system potential pathogenicity relevance. interplay immune system, nervous neurotransmitter synthesis, neuroplasticity transitions widely studied. consequences stress, dietary fibers, probiotics, prebiotics, antibiotics GB axis being Multiple revealed this led development effective microbiota-based drugs for both prevention treatment. Therefore, results support hypothesis that influences provide promising area research improved knowledge etiology disease future

Language: Английский

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Traditional Chinese medicine treats ulcerative colitis by regulating gut microbiota, signaling pathway and cytokine: Future novel method option for pharmacotherapy

Heliyon, Journal Year: 2024, Volume and Issue: 10(6), P. e27530 - e27530

Published: March 1, 2024

BackgroundUlcerative colitis (UC) is a chronic non-specific inflammatory disease with intestinal tract as the main site. The pathogenic of UC has not yet been clarified, and multiple mechanisms can lead to pathogenesis UC. Traditional Chinese medicine (TCM) offers an opportunity for treatment. TCM become preferred treatment characteristics targets, pathways high safety. This review attempted summarize (compound prescriptions, single herbs, active ingredients) discussed their based on analyzing UC-related gut microbiota, signaling pathway cytokine. In order provide more systematic diverse reference in prevention UC, theoretical clinical UC.Materials methodsThe information was acquired from different databases, including Web Science, PubMed, CNKI, Wanfang, VIP databases. We then focused recent research progress by TCM. Finally, deficiencies future perspectives are proposed.ResultsModern pharmacological studies have shown that compound prescriptions (strengthening spleen, clearing heat removing dampness, toxin), herbs (replenishing Qi, heat, tonifying blood, etc.), ingredients (alkaloids, polysaccharides, flavonoids, polyphenols, terpenes, etc.) efficiency regulating cytokine.ConclusionsTCM achieve its purpose acting ways, deserves further development this field.

Language: Английский

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Sijunzi decoction alleviates inflammation and intestinal epithelial barrier damage and modulates the gut microbiota in ulcerative colitis mice

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: April 8, 2024

Ethnopharmacological relevance: As a representative classical prescription, Sijunzi decoction has powerful therapeutic effects on spleen–stomach qi insufficiency. Ulcerative colitis (UC) is chronic, diffuse, and non-specifically inflammatory disorder, the etiology of which still remains unclear. In traditional Chinese medicine (TCM) perspective, splenic asthenia primary cause UC. Based this, been extensively used in TCM clinical practice to alleviate UC recent years. However, pharmacological mechanism modern not completely clear, limits its application. Aim study: The purpose this study was investigate decoction’s curative effect acute mice probe into potential mechanism. Materials methods: mouse model set up by freely ingesting 3% dextran sulfate sodium (DSS) solution. relieving role analyzed evaluating changes parameters, colon morphology, histopathology, factor content, intestinal epithelial barrier protein expression level, gut microbiota balance state. Finally, multivariate statistical analysis conducted elucidate relationship between factors, proteins, microbiota. Results: First, research findings revealed that could visibly ease manifestation UC, lower DAI score, attenuate colonic damage. Moreover, also significantly inhibit IL-6, IL-1β, TNF-α while increasing occludin ZO-1 levels. Subsequently, further studies showed remodel homeostasis. beneficial regulating levels Alistipes, Akkermansia, Lachnospiraceae_NK4A136_group, other bacteria. demonstrated key microbes were closely associated with factors proteins. Conclusion: can prevent treat Its strongly improvement inflammation damage

Language: Английский

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A comprehensive review on palladium nanocatalysts in carbonylative Suzuki-coupling reactions

Journal of Coordination Chemistry, Journal Year: 2024, Volume and Issue: 77(12-14), P. 1324 - 1348

Published: July 15, 2024

Carbonylative Suzuki–Miyaura coupling is an attractive and efficient strategy for preparation of diaryl ketones. reactions are difficult palladium complexes popular catalysts. The use as catalysts allows the reaction to be carried out under milder conditions ketone products prepared with good high yields. nanocatalysts has become effective performing complex especially carbonylative because have characteristics both homogeneous heterogeneous catalytic systems. In this review, we study application ketones through aryl halides, arylboronic acids carbonyl sources. Based on internet code survey research, paper first review in reactions. We believe will a valuable source chemists working field or

Language: Английский

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Multi-omics integrated analyses indicated that non-polysaccharides of Sijunzi decoction ameliorated spleen deficiency syndrome via regulating microbiota-gut-metabolites axis and exerted synergistic compatibility

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 331, P. 118276 - 118276

Published: May 1, 2024

Language: Английский

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Recent Advances on Multicomponent Synthesis of Pyranopyrazoles Using Magnetically Recoverable Nanocatalysts

Polycyclic aromatic compounds, Journal Year: 2023, Volume and Issue: 44(7), P. 4932 - 4978

Published: Sept. 13, 2023

AbstractThe synthesis of heterocyclic compounds is always one the most important challenges among synthetic chemists. Pyranopyrazoles are an class that a rich source biologically molecules. These derivatives present as key structures in natural products, bioactive, and biological So far, many catalytic systems methods have been reported for these compounds. However, pyranopyrazoles through multicomponent reactions great importance, especially from point view green chemistry. During last decade, use magnetic materials catalysts organic compounds, heterocycles, has created huge revolution The easy fast separation nanocatalysts using only external magnet advantage this type catalyst, addition to complete catalyst field, ability be reused, which leads cost reduction savings. This paper covers applications magnetically recoverable nanoparticles pyranopyrazole derivatives. In review, we discussed on detials conditions well presented mechanisms their preparation presence nanomagnetic reusable catalysts.Keywords: Pyranopyrazolesmagnetic nancatalystsmagnetic seperationmulticomonent reactionssynthetic chemistry Disclosure statementNo potential conflict interest was by author(s).

Language: Английский

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