A long-acting prolactin to combat lactation insufficiency DOI Creative Commons
Kasia M. Kready, Kailyn E. Doiron,

Katherine Redfield Chan

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 15, 2023

Abstract Human infants are born to breastfeed. While 50% of lactating persons struggle make enough milk, there no governmentally-approved drugs enhance lactation 1 . Here, we engineer a variant the naturally-occurring driver lactation, hormone Prolactin, increase its serum half-life and produce viable drug candidate. Our engineered variant, Prolactin-eXtra Long-acting (Prolactin-XL), is comprised endogenously active human prolactin fused an IgG Fc domain designed overcome unique development challenges specific person-infant dyad. Prolactin-XL has 70.9h in mice, 2,625-fold longer than alone (70.9h v. 0.027h). We demonstrate that increases milk production restores growth pups fed by dams with pharmacologically-ablated lactation. show Prolactin-XL-enhanced accompanied reversible, lactocyte-driven changes mammary gland morphology. This work establishes long-acting prolactins as potentially powerful pharmacologic means combat insufficient

Language: Английский

Global lessons for strengthening breastfeeding as a key pillar of food security DOI Creative Commons
Cecília Tomori

Frontiers in Public Health, Journal Year: 2023, Volume and Issue: 11

Published: Aug. 22, 2023

Breastfeeding is identified as a central pillar of food security by the World Health Organization, however globally significant challenges remain in achieving breastfeeding targets for early initiation, exclusive 6 months, and continued 2 years beyond. Inadequate support health systems, poor maternity protections workplace policies, insufficient regulation commercial milk formulas, among other barriers, continue to undermine this key across nations. This paper highlights importance diverse global settings examining three case studies: Honduras, Pakistan USA. The cases highlight complex layering intersections that threaten era pandemics, climate crisis, conflict inequality. Lessons drawn from these studies, combined with additional insights, reinforce multisectorial collaboration scale up investment creating equitable, enabling environments breastfeeding. These structural systems approaches can successfully strengthen ecosystem ensure greater first system resilience face crises, which compound maternal infant vulnerabilities. Additionally, add urgency attention prioritizing incorporating IYCF-E protocols into disaster preparedness management policy agenda, well ensuring considered energy policy. An integrated approach change necessary recognize pivotal part globe.

Language: Английский

Citations

19

Infant Formula in the Digital Age: How US Online Formula Marketing Targets Parents DOI Creative Commons

Simone Froley,

Cristina Watkins,

Cecília Tomori

et al.

Maternal and Child Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

ABSTRACT Despite recommendations by the International Code of Marketing Breastmilk Substitutes (the Code), regulatory bodies in United States continue to permit commercial milk formula (CMF) marketing that threatens public health. The increasing popularity online shopping highlights need for more research on virtual CMF product marketing. To assess strategies from e‐customer standpoint, we analyzed a sample 26 bestselling infant (IF) products three US‐based e‐commerce giants. All display content, including visual and audible components, was evaluated according guidelines, thematically assessed theme co‐occurrence. No IF labels were compliant with due widespread health benefit claims idealization IF. Furthermore, no critical guidelines powdered reconstitution instructions. Thematic analysis web pages revealed 17 themes, which four novel literature: purity , nature innovation eco‐friendly . These themes co‐occurred patterned ways capture consumers. most popular combine violations compelling materials idealize shape cultural expectations about feeding care. practices reinforce industry's well‐documented efforts undermine breastfeeding. A review US regulations implementation is urgently needed protect

Language: Английский

Citations

0

Allomilk: An Anthropogeny-Based Framework for Human Milk as a Climate Solution DOI
Emily Little

Journal of Human Lactation, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 4, 2024

Climate change is an urgent threat to perinatal and infant health, with the greatest effects of climate exposures being felt disproportionately by global majority communities who have been most harmed systems oppression. Human milk feeding one recognized solution bolster resilience. Yet, policies practices support human as a are inconsistent under-prioritized, which unsurprising given lack alignment between history current cultural context regard lactation access. This paper presents new framework on solution, unique in its incorporation critical cooperative breastfeeding our species. Rooted anthropogeny, or study origins, antiracist principles lactation, Allomilk Framework highlights five concepts ideal application bridging ancient allonursing present-day These applications—and proposed development measures operationalize them—will advance field through shared understanding qualities that should be prioritized assessment at intersection resilience Application assess design future will increasing potential for mitigation while working with—rather than against—the importance history.

Language: Английский

Citations

0

A long-acting prolactin to combat lactation insufficiency DOI Creative Commons
Kasia M. Kready, Kailyn E. Doiron,

Katherine Redfield Chan

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 15, 2023

Abstract Human infants are born to breastfeed. While 50% of lactating persons struggle make enough milk, there no governmentally-approved drugs enhance lactation 1 . Here, we engineer a variant the naturally-occurring driver lactation, hormone Prolactin, increase its serum half-life and produce viable drug candidate. Our engineered variant, Prolactin-eXtra Long-acting (Prolactin-XL), is comprised endogenously active human prolactin fused an IgG Fc domain designed overcome unique development challenges specific person-infant dyad. Prolactin-XL has 70.9h in mice, 2,625-fold longer than alone (70.9h v. 0.027h). We demonstrate that increases milk production restores growth pups fed by dams with pharmacologically-ablated lactation. show Prolactin-XL-enhanced accompanied reversible, lactocyte-driven changes mammary gland morphology. This work establishes long-acting prolactins as potentially powerful pharmacologic means combat insufficient

Language: Английский

Citations

0