Mitochondrial Quality Control Orchestrates the Symphony of B Cells and Plays Critical Roles in B Cell‐Related Diseases DOI Creative Commons

Wuhao Li,

Peiyang Cai,

Ye Xu

et al.

Journal of Immunology Research, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

B cells are essential for humoral immune response due to their ability secrete antibodies. The development of from the bone marrow periphery is tightly regulated by a complex set signals, and each subset has unique metabolic profile. Mitochondria, which serve as cellular energy powerhouses, play an role in regulating cell survival responses. To maintain homeostasis, mitochondria dynamically adjust morphology, distribution, mass via biogenesis, fusion fission, translocation, mitophagy. Despite its extreme importance, mitochondrial quality control (MQC) not been thoroughly summarized, unlike T cells. This article aims review mechanism MQC that shapes fate functions. In addition, we will discuss physiological pathological implications cells, providing new insights into potential therapeutic targets diseases associated with abnormalities.

Language: Английский

Fundamentals of redox regulation in biology DOI
Helmut Sies, Ryan J. Mailloux,

Ursula Jakob

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2024, Volume and Issue: 25(9), P. 701 - 719

Published: April 30, 2024

Language: Английский

Citations

134

Mitochondrial dynamics and psychiatric disorders: The missing link DOI
Maria P. Papageorgiou, Michaela D. Filiou

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 165, P. 105837 - 105837

Published: July 30, 2024

Language: Английский

Citations

9

Comparative 3D ultrastructure of Plasmodium falciparum gametocytes DOI Creative Commons
Felix Evers, Rona Roverts, Cas Boshoven

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 2, 2025

Abstract Despite the enormous significance of malaria parasites for global health, some basic features their ultrastructure remain obscure. Here, we apply high-resolution volumetric electron microscopy to examine and compare transmissible male female sexual blood stages Plasmodium falciparum as well more intensively studied asexual revisiting previously described phenomena in 3D. In doing so, challenge widely accepted notion a single mitochondrion by demonstrating presence multiple mitochondria gametocytes. We also provide evidence gametocyte-specific cytostome, or cell mouth. Furthermore, generate first 3D reconstructions parasite’s endoplasmic reticulum (ER) Golgi apparatus gametocyte-induced extraparasitic structures infected red cell. Assessing interconnectivity between organelles, find frequent structural appositions nucleus, mitochondria, apicoplast. that ER is promiscuous interactor with numerous organelles trilaminar pellicle gametocyte. Public availability these resources will facilitate reinterrogation others different research questions expertise. Taken together, reconstruct P. gametocytes at nanometre scale shed light on unique organellar biology deadly parasites.

Language: Английский

Citations

1

A New Perspective on the Role of Alterations in Mitochondrial Proteins Involved in ATP Synthesis and Mobilization in Cardiomyopathies DOI Open Access
Melissa Vázquez-Carrada, María Magdalena Vilchis‐Landeros, Héctor Vázquez‐Meza

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2768 - 2768

Published: March 19, 2025

The heart requires a continuous energy supply to sustain its unceasing contraction–relaxation cycle. Mitochondria, double-membrane organelle, generate approximately 90% of cellular as adenosine triphosphate (ATP) through oxidative phosphorylation, utilizing the electrochemical gradient established by respiratory chain. Mitochondrial function is compromised damage mitochondrial DNA, including point mutations, deletions, duplications, or inversions. Additionally, disruptions proteins associated with membranes regulating metabolic homeostasis can impair chain’s efficiency. This results in diminished ATP production and increased generation reactive oxygen species. review provides an overview mutations affecting transporters involved synthesis, particularly those synthesis mobilization, it examines their role pathogenesis specific cardiomyopathies.

Language: Английский

Citations

1

Molecular machineries shaping the mitochondrial inner membrane DOI
Oliver Daumke, Martin van der Laan

Nature Reviews Molecular Cell Biology, Journal Year: 2025, Volume and Issue: unknown

Published: May 14, 2025

Language: Английский

Citations

1

SFRRI Inaugural Alberto Boveris Award Lecture Dynamics of Intracellular and Intercellular Redox Communication DOI Creative Commons
Helmut Sies

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 225, P. 933 - 939

Published: Nov. 1, 2024

Language: Английский

Citations

6

USP7 Promotes Cardiometabolic Disorders and Mitochondrial Homeostasis Dysfunction in Diabetic Mice via stabilizing PGC1β DOI Creative Commons
Meiling Yan,

Liyan Su,

Kaile Wu

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 205, P. 107235 - 107235

Published: May 28, 2024

Diabetic cardiomyopathy (DCM) is a major complication of diabetes and characterized by left ventricular dysfunction. Currently, there lack effective treatments for DCM. Ubiquitin-specific protease 7 (USP7) plays key role in various diseases. However, whether USP7 involved DCM has not been established. In this study, we demonstrated that was upregulated diabetic mouse hearts NMCMs co-treated with HG+PA or H9c2 cells treated PA. Abnormalities heart morphology function were reversed silencing through conditional gene knockout chemical inhibition. Proteomic analysis coupled biochemical validation confirmed PCG1β one the direct protein substrates aggravated myocardial damage coactivation PPARα signaling pathway. restored expression fatty acid metabolism-related proteins mitochondrial homeostasis inhibiting fission promoting fusion events. Similar effects also observed vitro. Our data promoted cardiometabolic metabolism disorders dysfunction via stabilizing suggested may be therapeutic strategy

Language: Английский

Citations

4

SLP2 and MIC13 synergistically coordinate MICOS assembly and crista junction formation DOI Creative Commons
Ritam Naha, Rebecca Strohm, Yulia Schaumkessel

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(12), P. 111467 - 111467

Published: Nov. 23, 2024

The MICOS complex, essential for cristae organization, comprises MIC10 and MIC60 subcomplexes, with MIC13 as a crucial subunit. mutations cause severe mitochondrial hepato-encephalopathy, defects, MIC10-subcomplex loss. We demonstrate that depletion of the protease YME1L in KO stabilizes MIC10-subcomplex, restoring MIC60-MIC10 interaction crista junction (CJ) indicating is stabilization rather than bridging. identified stomatin-like protein 2 (SLP2) key partner, morphology CJ formation. SLP2 serves an hub subunits MIC26 by protecting it from YME1L-mediated degradation. Deleting both impairs MIC60-subcomplex assembly its nanoscale organization. Restoring MIC13-SLP2 double cells through reinstates morphology. Overall, we propose act proteolytically controlled 'seeder' facilitating MICOS-MIB complex maintaining integrity.

Language: Английский

Citations

3

Acetaldehyde dehydrogenase 2 attenuates lipopolysaccharide -induced endothelial barrier damage by inhibiting mitochondrial fission in sepsis-associated encephalopathy DOI
Shasha Wang, Zhongyi Liu, Rong Li

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177468 - 177468

Published: March 1, 2025

Language: Английский

Citations

0

Mitochondrial fusion and cristae reorganization facilitate acquisition of cardiomyocyte identity during reprogramming of murine fibroblasts DOI Creative Commons
Brian Spurlock, Yifang Xie, Yiran Song

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(3), P. 115377 - 115377

Published: March 1, 2025

Cardiomyocytes (CMs) rely on mitochondrial energy produced in highly interconnected networks. Direct reprogramming of cardiac fibroblasts (CFs) into induced CMs (iCMs) shows promise for treating injury, but little work has investigated energetics and morphology during the conversion CFs to iCMs. We characterized mitochondria direct murine neonatal (mnCFs). Reprogramming increased respiration interconnectivity not levels native CMs. therefore whether perturbations dynamics impacted reprogramming. Mitochondrial fusion (joining) was essential iCM generation, while various fission (dividing) genes were barriers. In particular, loss regulator 1 like (Mtfr1l) significantly yield functionally mature iCMs respiration. These changes countered by concomitant effector optical atrophy protein (Opa1). The present study advances our understanding barriers mechanisms

Language: Английский

Citations

0